Search Results - "Oncology reports"

Non-coding RNAs as regulators in epigenetics by Wei, Jian-Wei, Huang, Kai, Yang, Chao, Kang, Chun-Sheng

“…Epigenetics is a discipline that studies heritable changes in gene expression that do not involve altering the DNA sequence. Over the past decade, researchers…”
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Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo by Hashemzaei, Mahmoud, Far, Amin Delarami, Yari, Arezoo, Heravi, Reza Entezari, Tabrizian, Kaveh, Taghdisi, Seyed Mohammad, Sadegh, Sarvenaz Ekhtiari, Tsarouhas, Konstantinos, Kouretas, Dimitrios, Tzanakakis, George, Nikitovic, Dragana, Anisimov, Nikita Yurevich, Spandidos, Demetrios A, Tsatsakis, Aristides M, Rezaee, Ramin

“…The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120…”
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Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review) by Yang, Ling, Xie, Hong-Jian, Li, Ying-Ying, Wang, Xia, Liu, Xing-Xin, Mai, Jia

“…Cisplatin is one of the most effective chemotherapy drugs for ovarian cancer, but resistance is common. The initial response to platinum‑based chemotherapy is…”
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Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer by IMAMURA, YOSHINORI, MUKOHARA, TORU, SHIMONO, YOHEI, FUNAKOSHI, YOHEI, CHAYAHARA, NAOKO, TOYODA, MASANORI, KIYOTA, NAOMI, TAKAO, SHINTARO, KONO, SEISHI, NAKATSURA, TETSUYA, MINAMI, HIRONOBU

“…It is becoming recognized that screening of oncology drugs on a platform using two-dimensionally (2D)-cultured cell lines is unable to precisely select…”
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Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer by Gao, Jianwei, Qiu, Xiangyu, Xi, Guangmin, Liu, Hongbing, Zhang, Fang, Lv, Tangfeng, Song, Yong

“…Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL‑1β,…”
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Cancer drug delivery in the nano era: An overview and perspectives by Li, Zhen, Tan, Shirui, Li, Shuan, Shen, Qiang, Wang, Kunhua

“…Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials also appeal to researchers in the areas of cancer diagnosis and…”
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Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor by Yu, Haochen, Yang, Chengcheng, Jian, Lei, Guo, Shipeng, Chen, Rui, Li, Kang, Qu, Fanli, Tao, Kai, Fu, Yong, Luo, Feng, Liu, Shengchun

“…The aim of the present study was to clarify the activation of ferroptosis in different breast cancer cells by sulfasalazine (SAS) and to explore the…”
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ACSL4 suppresses glioma cells proliferation via activating ferroptosis by Cheng, Jing, Fan, Yan-Qin, Liu, Bao-Hui, Zhou, Han, Wang, Jun-Min, Chen, Qian-Xue

“…Acyl‑CoA synthetase long‑chain family member 4 (ACSL4) is a member of the long chain family of acyl‑CoA synthetase proteins, which have recently been shown to…”
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Cancer‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma by Sun, Li-Ping, Xu, Kai, Cui, Jing, Yuan, Dao-Ying, Zou, Bo, Li, Jun, Liu, Jian-Lin, Li, Ke-Yi, Meng, Zhen, Zhang, Bin

“…Oral squamous cell carcinoma (OSCC), with high potential for metastasis, is the most common malignant tumor of the head and neck. Cancer‑associated…”
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HSP90 inhibitors and cancer: Prospects for use in targeted therapies (Review) by Li, Zi-Nan, Luo, Ying

“…Heat shock protein 90 (HSP90) is a vital chaperone protein, regulating signaling pathways and correcting misfolded proteins in cancer cells by interacting with…”
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CAR T cell therapy: A new era for cancer treatment (Review) by Mohanty, Rimjhim, Chowdhury, Chitran Roy, Arega, Solomon, Sen, Prakriti, Ganguly, Pooja, Ganguly, Niladri

“…Cancer has recently been identified as the leading cause of mortality worldwide. Several conventional treatments and cytotoxic immunotherapies have been…”
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Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization by Chen, Xin, Ying, Xiang, Wang, Xinjing, Wu, Xiaoli, Zhu, Qinyi, Wang, Xipeng

“…Hypoxia is a common feature of solid tumors. It is closely related to tumor progression. Exosomal microRNAs derived from cancers are considered to be mediators…”
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Role of the tumor microenvironment in tumor progression and the clinical applications (Review) by YUAN, YAO, JIANG, YU-CHEN, SUN, CHONG-KUI, CHEN, QIAN-MING

“…Oncogene activation and tumor-suppressor gene inactivation are considered as the main causes driving the transformation of normal somatic cells into malignant…”
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Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer by Lei, Yi, Guo, Wang, Chen, Bowang, Chen, Lu, Gong, Jiaxin, Li, Weimin

“…Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become one major obstacle for improving the clinical outcome of patients with…”
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Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway by Zeng, Anqi, Liang, Xin, Zhu, Shaomi, Liu, Chi, Wang, Shu, Zhang, Qinxiu, Zhao, Junning, Song, Linjiang

“…Breast cancer which is the most common type of diagnosed cancer among women worldwide possesses metastatic potential, multi‑drug resistance, and high…”
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Genetics, diagnosis and management of colorectal cancer (Review) by DE ROSA, MARINA, PACE, UGO, REGA, DANIELA, COSTABILE, VALERIA, DURATURO, FRANCESCA, IZZO, PAOLA, DELRIO, PAOLO

“…Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading cause of cancer death. Surgery represents the mainstay of treatment in…”
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Screening and identification of key biomarkers in hepatocellular carcinoma: Evidence from bioinformatic analysis by Li, Lin, Lei, Qingsong, Zhang, Shujun, Kong, Lingna, Qin, Bo

“…Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Intense efforts have been made to elucidate the pathogeny, but the molecular…”
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Tumor‑infiltrating M2 macrophages driven by specific genomic alterations are associated with prognosis in bladder cancer by Xue, Yongping, Tong, Liping, LiuAnwei Liu, Fei, Liu, Anwei, Zeng, Shuxiong, Xiong, Qiao, Yang, Zeyu, He, Xing, Sun, Yinghao, Xu, Chuanliang

“…The present study aimed to explore the mechanism by which the immune landscape of the tumor microenvironment influences bladder cancer. CIBERSORT and ssGSEA…”
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Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2 by Lang, Hai-Li, Hu, Guo-Wen, Zhang, Bo, Kuang, Wei, Chen, Yong, Wu, Lei, Xu, Guo-Hai

“…Angiogenesis is a key event in the progression of gliomas. Exosomes, as signaling extracellular organelles, modulate the tumor microenvironment and promote…”
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MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review) by Hu, Mingli, Zhu, Shixuan, Xiong, Shengwei, Xue, Xingxing, Zhou, Xiaodong

“…Gastric carcinogenesis arises from complicated interactions among host, environmental and bacterial factors, which cause genetic and epigenetic dysregulation…”
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