Search Results - "Oncogene"

Circular RNAs in cancer: opportunities and challenges in the field by Kristensen, L S, Hansen, T B, Venø, M T, Kjems, J

“…Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a…”
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LncRNA-mediated regulation of cell signaling in cancer by Peng, W-X, Koirala, P, Mo, Y-Y

“…To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been…”
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Wnt signaling in cancer by Zhan, T, Rindtorff, N, Boutros, M

“…Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in…”
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Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer by Fong, Winnie, Li, Qing, Yu, Jun

“…Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse…”
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YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation by Zhang, Chuanzhao, Huang, Shanzhou, Zhuang, Hongkai, Ruan, Shiye, Zhou, Zixuan, Huang, Kaijun, Ji, Fei, Ma, Zuyi, Hou, Baohua, He, Xiaoshun

“…N 6 -methyladenosine (m6A) RNA methylation contributes to the cancer stem cell (CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was…”
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A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis by Zhang, Maolei, Huang, Nunu, Yang, Xuesong, Luo, Jingyan, Yan, Sheng, Xiao, Feizhe, Chen, Wenping, Gao, Xinya, Zhao, Kun, Zhou, Huangkai, Li, Ziqiang, Ming, Liu, Xie, Bo, Zhang, Nu

“…Circular RNAs (circRNAs) are recognized as functional non-coding transcripts in eukaryotic cells. Recent evidence has indicated that even though circRNAs are…”
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Census and evaluation of p53 target genes by Fischer, M

“…The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53 gene alters its response pathway, and is central to the…”
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Essential role of METTL3-mediated m 6 A modification in glioma stem-like cells maintenance and radioresistance by Visvanathan, A, Patil, V, Arora, A, Hegde, A S, Arivazhagan, A, Santosh, V, Somasundaram, K

“…Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible…”
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Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players by Yuan, Xiaotian, Larsson, Catharina, Xu, Dawei

“…Long-lived species Homo sapiens have evolved robust protection mechanisms against cancer by repressing telomerase and maintaining short telomeres, thereby…”
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Dual role of autophagy in hallmarks of cancer by Singh, Shikha Satendra, Vats, Somya, Chia, Amelia Yi-Qian, Tan, Tuan Zea, Deng, Shuo, Ong, Mei Shan, Arfuso, Frank, Yap, Celestial T., Goh, Boon Cher, Sethi, Gautam, Huang, Ruby Yun-Ju, Shen, Han Ming, Manjithaya, Ravi, Kumar, Alan Prem

“…Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and…”
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Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells by Richards, K E, Zeleniak, A E, Fishel, M L, Wu, J, Littlepage, L E, Hill, R

“…Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic ductal adenocarcinomas (PDACs). Current efforts to eradicate these…”
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The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network by Cheng, Maosheng, Sheng, Lu, Gao, Qian, Xiong, Qiuchan, Zhang, Haojie, Wu, Mingqing, Liang, Yu, Zhu, Fengyu, Zhang, Yingyin, Zhang, Xiuhong, Yuan, Quan, Li, Yang

“…N 6 -methyladenosine (m6A) is the most abundant modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its…”
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Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies by An, Zhenyi, Aksoy, Ozlem, Zheng, Tina, Fan, Qi-Wen, Weiss, William A.

“…Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play…”
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E-cadherin in contact inhibition and cancer by Mendonsa, Alisha M., Na, Tae-Young, Gumbiner, Barry M.

“…E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin…”
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Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways by Qian, Mingyu, Wang, Shaobo, Guo, Xiaofan, Wang, Jian, Zhang, Zongpu, Qiu, Wei, Gao, Xiao, Chen, Zihang, Xu, Jianye, Zhao, Rongrong, Xue, Hao, Li, Gang

“…Exosomes are emerging as important elements that participate in intercellular communication and tumor microenvironment modulation, but the exact mechanisms by…”
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Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7 by Zhang, Haiyang, Deng, Ting, Ge, Shaohua, Liu, Ying, Bai, Ming, Zhu, Kegan, Fan, Qian, Li, Jialu, Ning, Tao, Tian, Fei, Li, Hongli, Sun, Wu, Ying, Guoguang, Ba, Yi

“…Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in…”
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Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1 by Hsu, Y-L, Hung, J-Y, Chang, W-A, Lin, Y-S, Pan, Y-C, Tsai, P-H, Wu, C-Y, Kuo, P-L

“…Hypoxia plays a critical role during the evolution of malignant cells and tumour microenvironment (TME).Tumour-derived exosomes contain informative microRNAs…”
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Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations by Dankner, Matthew, Rose, April A. N., Rajkumar, Shivshankari, Siegel, Peter M., Watson, Ian R.

“…The RAS–RAF–MEK–ERK signaling cascade is among the most frequently mutated pathways in human cancer. Approximately 50% of melanoma patients possess a druggable…”
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Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis by Ladanyi, Andras, Mukherjee, Abir, Kenny, Hilary A., Johnson, Alyssa, Mitra, Anirban K., Sundaresan, Sinju, Nieman, Kristin M., Pascual, Gloria, Benitah, Salvador Aznar, Montag, Anthony, Yamada, S. Diane, Abumrad, Nada A., Lengyel, Ernst

“…Ovarian cancer (OvCa) is characterized by widespread and rapid metastasis in the peritoneal cavity. Visceral adipocytes promote this process by providing fatty…”
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A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma by Wu, Jie, Li, Lan, Zhang, Huibo, Zhao, Yaqi, Zhang, Haohan, Wu, Siyi, Xu, Bin

“…Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer. Therefore, this study was aimed to investigate the genes associated…”
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