Takayasu's arteritis: results of a university hospital of 45 patients in Turkey

Takayasu's arteritis: results of a university hospital of 45 patients in Turkey

Background: Takayasu's arteritis (TA) is a rare disease which appears to be most common in East Asia. However, the disease has been reported to be worldwide. The clinical features of the disease can show variations in different geographical areas. The aim of this study is to evaluate clinical,...

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Bibliographic Details
Published in:International journal of cardiology Vol. 96; no. 2; pp. 259 - 264
Main Authors: Ureten, Kemal, Öztürk, M.Akif, Onat, A.Mesut, Öztürk, M.Halil, Özbalkan, Zeynep, Güvener, Murat, Kiraz, Sedat, Ertenli, Ihsan, Calgüneri, Meral
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 01-08-2004
Elsevier Science
Subjects:
Adolescent
Adult
Age Distribution
Alternate-day glucocorticoids
Aortography - methods
Biological and medical sciences
Cardiology. Vascular system
Chi-Square Distribution
Cytotoxic agents
Female
Hospitals, University
Humans
Incidence
Male
Medical sciences
Middle Aged
Probability
Prognosis
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Takayasu Arteritis - diagnostic imaging
Takayasu Arteritis - epidemiology
Takayasu Arteritis - therapy
Takayasu's arteritis
Turkey - epidemiology
Asia
Turkey
Takayasu's arteritis
Alternate-day glucocorticoids
Cytotoxic agents
Human
Agent
Cardiovascular disease
Glucocorticoid
Result
Vascular disease
Vasculitis
Systemic disease
Hospital
Day
Takayashu arteritis
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Summary:Background: Takayasu's arteritis (TA) is a rare disease which appears to be most common in East Asia. However, the disease has been reported to be worldwide. The clinical features of the disease can show variations in different geographical areas. The aim of this study is to evaluate clinical, laboratory and radiological features and the outcome of patients with TA in our hospital. Methods: The hospital files of patients who were followed with the diagnosis of TA between the years 1973 and 2003 in Hacettepe University Hospital were retrospectively evaluated. Results: Male/female ratio was 5/40, and the mean age was 34 years (18–59). Constitutional symptoms were present in 71% of the patients. Claudication and pallor of the extremity, decreased extremity pulsations, arterial hypertension, and arterial bruits were present in 44%, 56%, 58%, and 27% of the patients, respectively. Aortic valvular insufficiency, abdominal aortic aneurism, and cardiomegaly were present in four, one, and four patients, respectively. The initial complaint of six patients was cerebrovascular events. The distribution of the patients according to the angiographic findings was as follows, 56% Type I, 18% Type II, 22% Type III, and 4% Type IV arteritis. The need for vascular surgical interventions were significantly less common in patients who were treated with immunosuppressives plus alternate dose steroids (6%) compared to patients who were treated only with antiaggregant agents (33%). Conclusions: The demographic and angiographic findings of our patients were similar to previous observations from Japan and Italy, and disclose distinct clinical features in comparison to other Asian countries. Alternate-day glucocorticoids plus cytotoxic drugs may be beneficial and safe in patients with TA.
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ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2003.07.017