Search Results - "Onaran, H O"

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand by Costa, T, Ogino, Y, Munson, P J, Onaran, H O, Rodbard, D

“…The mutual effects that a hormonal ligand (H) and a guanine nucleotide regulatory protein (G protein) exert on each other when simultaneously occupying…”
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Beta gamma subunits of guanine nucleotide-binding proteins and regulation of spontaneous receptor activity: thermodynamic model for the interaction between receptors and guanine nucleotide-binding protein subunits by Onaran, H O, Costa, T, Rodbard, D

“…We used a thermodynamic model to examine the interactions between receptor, guanine nucleotide-binding protein (G protein), and their ligands. The model…”
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Quasi-irreversible binding of agonist to beta-adrenoceptors and formation of non-dissociating receptor-G(s) complex in the absence of guanine nucleotides by Onaran, H O, Gurdal, H

“…Here, we tested the hypothesis that receptor-G protein and agonist may form an irreversible complex in the absence of guanine nucleotides. We used the…”
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Allosteric equilibrium model explains steady-state coupling of beta-adrenergic receptors to adenylate cyclase in turkey erythrocyte membranes by Ugur, O, Onaran, H O

“…We used a simple experimental approach to clarify some contradictory predictions of the collision coupling and equilibrium models (e.g. ternary complex,…”
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Acidic pH induces fusion of cells infected with baculovirus to form syncytia by Leikina, Evgenia, Onaran, H.Ongun, Zimmerberg, Joshua

“…The enveloped baculovirus⧹insect cell system has been used extensively for expression of recombinant proteins. including viral fusion proteins. We tested…”
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Pharmacokinetics of recombinant human erythropoietin in children with chronic renal failure by Cakar, N, Ekim, M, Tümer, N, Yalçinkaya, F, Akar, N, Onaran, H O

“…Basal erythropoietin (Epo) levels and single dose-pharmacokinetics of recombinant human erythropoietin (rhuEpo) were investigated in 8 predialysis (PD)…”
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Pharmacokinetics of phenprobamate after oral administration to healthy subjects by Tulunay, F C, Onaran, H O, Ergün, H, Ucar, A, Usanmaz, S, Embil, K, Tulunay, M

“…Phenprobamate (CAS 673-31-4) is a centrally acting skeletal-muscle relaxant agent. There are only two studies in the literature about the pharmacokinetics of…”
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Ca2+-induced inhibition of adenylyl cyclase in turkey erythrocyte membranes by Demirel, E, Ugur, O, Onaran, H O

“…We investigated the effects of calcium ions (Ca2+) on the adenylyl cyclase activity in purified turkey erythrocyte membranes. Results showed the following: (i)…”
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Agonist efficacy and allosteric models of receptor action by Onaran, H O, Costa, T

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Heterogeneity of histamine H2-receptor mediated responses in the rabbit aorta by Onaran, H O, Bökesoy, T A

“…Distribution and properties of histamine H2-receptor mediated responses in segments of rabbit aorta was studied with histamine and H2-receptor stimulating…”
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Kinetics of antagonism at histamine-H1 receptors in isolated rabbit arteries by ONGUN ONARAN, H, ARDA BOÊKESOY, T

“…Kinetics of antagonist-induced decrease of histamine-H1 receptor-mediated steady-state responses in isolated rabbit arteries were studied in the presence of…”
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Lysolipids reversibly inhibit Ca(2+)-, GTP- and pH-dependent fusion of biological membranes by Chernomordik, L V, Vogel, S S, Sokoloff, A, Onaran, H O, Leikina, E A, Zimmerberg, J

“…Membrane fusion in exocytosis, intracellular trafficking, and enveloped viral infection is thought to be mediated by specialized proteins acting to merge…”
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Coupling of beta2-adrenoceptors to XLalphas and Galphas: a new insight into ligand-induced G protein activation by Kaya, A I, Ugur, O, Oner, S S, Bastepe, M, Onaran, H O

“…Galpha(s) and extra-large Galpha(s) (XLalpha(s)) can both transduce receptor activation into intracellular cAMP generation. It is unknown, however, whether…”
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An efficacy-dependent effect of cardiac overexpression of beta2-adrenoceptor on ligand affinity in transgenic mice by Gürdal, H, Bond, R A, Johnson, M D, Friedman, E, Onaran, H O

“…In previous studies, it was shown that the overexpression of beta2-adrenoceptor (beta2AR) in the hearts of transgenic mice (Tg) leads to agonist-independent…”
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Decrease in Apparent Alphax1-Adrenoceptor-G Protein Coupling During Maturation in Rat Aorta by Gurdal, Hakan, Friedman, Eitan, Johnson, Mark D., Onaran, H. Ongun

“…We have previously shown that the adrenoceptor agonist norepinephrine (NE) is more potent in eliciting contractionin aortas from 1-month-old Fischer 344 rats…”
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Decrease in apparent alpha1-adrenoceptor-G protein coupling during maturation in rat aorta by Gurdal, H, Friedman, E, Johnson, M D, Onaran, H O

“…We have previously shown that the adrenoceptor agonist norepinephrine (NE) is more potent in eliciting contraction in aortas from 1-month-old Fischer 344 rats…”
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Role of alpha-adrenoceptors in the effects of buspirone and 5-carboxamidotryptamine in rabbit isolated thoracic aorta by Gürdal, H, Onaran, H O, Tulunay, F C

“…1. The role of alpha-adrenoceptors in the vascular effects of buspirone (BUS) and 5-carboxamidotryptamine (5-CT) was investigated in rabbit thoracic aorta. 2…”
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Regional histaminergic potencies in rabbit systemic circulation by Gürbüz, H, Onaran, H O, Bökesoy, T A

“…1. Regional activity of histamine was studied in various rabbit arteries, including segments of the aorta, aortic branches, branchout regions and arteries to…”
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Correlation between affinity and efficacy: Response from Kenakin and Onaran by Kenakin, Terry P., Onaran, H.Ongun

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Ligand efficacy and affinity in an interacting 7TM receptor model by Ongun Onaran, Hasan, Gürdal, Hakan

“…Quantitative understanding of the activation of G protein-coupled receptors is based mostly on some theoretical models that describe the interaction between…”
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