Search Results - "Ona, V."

Long-term safety and frequency of repeat zuranolone treatment in patients with major depressive disorder rolling over from the randomised CORAL Study into the open-label SHORELINE Study by Mattingly, G W, Mathew, S J, Parikh, S V, Aaronson, S T, Baune, B T, Czysz, A, Nandy, I, Ona, V, Brown, C, Kyaga, S, restal, F, Levin, S, Doherty, J, Mattingly, G

“…IntroductionZuranolone (ZRN) is a positive allosteric modulator of both synaptic and extrasynaptic gamma-aminobutyric acid type A receptors and a neuroactive…”
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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease by Friedlander, Robert M, Ona, Victor O, Li, Mingwei, Vonsattel, Jean Paul G, Andrews, L. John, Khan, Sohail Q, Chung, Woosik M, Frey, Ariel S, Menon, Anil S, Li, Xiao-Jiang, Stieg, Philip E, Yuan, Junying, Penney, John B, Young, Anne B, Cha, Jang-Ho J

“…Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder resulting in specific neuronal loss and dysfunction in the striatum and…”
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Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury by Li, M., Ona, V.O., Chen, M., Kaul, M., Tenneti, L., Zhang, X., Stieg, P.E., Lipton, S.A., Friedlander, R.M.

“…Evidence indicates that both necrotic and apoptotic cell death contribute to tissue injury and neurological dysfunction following spinal cord injury. Caspases…”
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Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction by Sanchez Mejia, R O, Ona, V O, Li, M, Friedlander, R M

“…Caspase-1 plays an important functional role mediating neuronal cell death and dysfunction after experimental traumatic brain injury (TBI) in mice…”
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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease by Friedlander, Robert M, Chen, Minghua, Ona, Victor O, Li, Mingwei, Ferrante, Robert J, Fink, Klaus B, Zhu, Shan, Bian, Jie, Guo, Lei, Farrell, Laurie A, Hersch, Steve M, Hobbs, Wendy, Vonsattel, Jean-Paul, Cha, Jang-Ho J

“…Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline derivative with proven safety…”
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Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model by Li, Mingwei, Ona, Victor O., Guégan, Christelle, Chen, Minghua, Jackson-Lewis, Vernice, Andrews, L. John, Olszewski, Adam J., Stieg, Philip E., Jean-Pyo. Lee, Przedborski, Serge, Friedlander, Robert M.

“…Mutations in the copper/zinc Superoxide dismutase (SOD1) gene produce an animal model of familial amyotrophic lateral sclerosis (ALS), a fatal…”
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Prevalence of Helicobacter pylori in peptic ulcer patients in greater Rochester, NY : Is empirical triple therapy justified? by JYOTHEESWARAN, S, SHAH, A. N, JIN, H. O, POTTER, G. D, ONA, F. V, CHEY, W. Y

“…Among patients with peptic ulcer disease, the prevalence of Helicobacter pylori has been reported to range from 80% to 90%. Thus empirical cost-effective…”
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Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade by Fink, K.B., Andrews, L.J., Butler, W.E., Ona, V.O., Li, M., Bogdanov, M., Endres, M., Khan, S.Q., Namura, S., Stieg, P.E., Beal, M.F., Moskowitz, M.A., Yuan, J., Friedlander, R.M.

“…Necrotic and apoptotic cell death both play a role mediating tissue injury following brain trauma. Caspase-1 (interleukin-1β converting enzyme) is activated…”
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CARDIOVASCULAR RISK IN THE FIRST YEAR OF HRT by Ona, D, Ona, V, Lucan, L, Sitar, A, Zdrenghea, D

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UP-1.71: Urinary continence after open, laparoscopic and robotic prostatectomy: a single center experience by El Aidi, Y, Crisan, N, Feciche, B, Stanca, D, Lapusan, C, Manea, C, Prundus, P, Neiculescu, C, Ona, V, Coman, I

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Malonate and 3‐Nitropropionic Acid Neurotoxicity Are Reduced in Transgenic Mice Expressing a Caspase‐1 Dominant‐Negative Mutant by Andreassen, Ole A, Ferrante, Robert J, Hughes, Duncan B, Klivenyi, Peter, Dedeoglu, Alpaslan, Ona, Victor O, Friedlander, Robert M, Beal, M Flint

“…Increasing evidence implicates caspase‐1‐mediated cell death as a major mechanism of neuronal death in neurodegenerative diseases. In the present study we…”
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53 POSTER Combination treatment of VEGFR inhibitor AV-951 and rapamycin reveals distinct mechanisms of each agent's anti-tumor activity by Robinson, M, Lin, J, Yang, H, Sun, X, Ona, V, Kannan, K, Heyer, J, Meng, G, Zhou, Y, Rideout, W

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Long-term efficacy and safety of intra-articular sprifermin in patients with knee osteoarthritis: results from the 5-year forward study by Eckstein, F., Hochberg, M., Kraines, J., Guehring, H., Moreau, F., Ona, V., Bihlet, A.R., Byrjalsen, I., Andersen, J.R., Daelken, B., Guenther, O., Ladel, C., Michaelis, M., Conaghan, P.G.

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Clonorchis-associated cholangiocarcinoma: a report of two cases with unusual manifestations by Ona, F V, Dytoc, J N

“…Two cases of Clonorchis-associated cholangiocarcinoma are described along with their cholangiographic features to illustrate the spectrum of pathology ascribed…”
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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice by Friedlander, Robert M, Zhu, Shan, Stavrovskaya, Irina G, Drozda, Martin, Kim, Betty Y. S, Ona, Victor, Li, Mingwei, Sarang, Satinder, Liu, Allen S, Hartley, Dean M, Wu, Du Chu, Gullans, Steven, Ferrante, Robert J, Przedborski, Serge, Kristal, Bruce S

“…Minocycline mediates neuroprotection in experimental models of neurodegeneration. It inhibits the activity of caspase-1, caspase-3, inducible form of nitric…”
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V13 Robot assisted repair of a complex vesicovaginal fistula using an omental flap, according to Kiricuta & Goldstein technique by Coman, I, Manea, C.N, Crisan, N, Dobrota, F, Ona, V, Porumb, C, Chira, C

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Mt. Carmel House: a home for terminally ill patients who cannot go home by Smith, J, Ona, F V

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Rectal bleeding due to diversion colitis by Ona, F V, Boger, J N

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Gastric sarcoid: unusual cause of upper gastrointestinal hemorrhage by Ona, F V

“…An unusual presentation of sarcoidosis was noted in a patient who developed severe upper gastrointestinal hemorrhage. The bleeding was attributed to a sarcoid…”
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Phylogeography of Cedros and Tiburón Island Mule Deer in North America’s Desert Southwest by Alminas, Ona S V, Heffelfinger, James R, Statham, Mark J, Latch, Emily K

“…Abstract Though mule deer (Odocoileus hemionus) persist in robust populations throughout most of their North American distribution, habitat loss, unregulated…”
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