Search Results - "Ona, V O"

Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury by Li, M., Ona, V.O., Chen, M., Kaul, M., Tenneti, L., Zhang, X., Stieg, P.E., Lipton, S.A., Friedlander, R.M.

“…Evidence indicates that both necrotic and apoptotic cell death contribute to tissue injury and neurological dysfunction following spinal cord injury. Caspases…”
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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease by Friedlander, Robert M, Ona, Victor O, Li, Mingwei, Vonsattel, Jean Paul G, Andrews, L. John, Khan, Sohail Q, Chung, Woosik M, Frey, Ariel S, Menon, Anil S, Li, Xiao-Jiang, Stieg, Philip E, Yuan, Junying, Penney, John B, Young, Anne B, Cha, Jang-Ho J

“…Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder resulting in specific neuronal loss and dysfunction in the striatum and…”
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Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade by Fink, K.B., Andrews, L.J., Butler, W.E., Ona, V.O., Li, M., Bogdanov, M., Endres, M., Khan, S.Q., Namura, S., Stieg, P.E., Beal, M.F., Moskowitz, M.A., Yuan, J., Friedlander, R.M.

“…Necrotic and apoptotic cell death both play a role mediating tissue injury following brain trauma. Caspase-1 (interleukin-1β converting enzyme) is activated…”
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Malonate and 3‐Nitropropionic Acid Neurotoxicity Are Reduced in Transgenic Mice Expressing a Caspase‐1 Dominant‐Negative Mutant by Andreassen, Ole A, Ferrante, Robert J, Hughes, Duncan B, Klivenyi, Peter, Dedeoglu, Alpaslan, Ona, Victor O, Friedlander, Robert M, Beal, M Flint

“…Increasing evidence implicates caspase‐1‐mediated cell death as a major mechanism of neuronal death in neurodegenerative diseases. In the present study we…”
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Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction by Sanchez Mejia, R O, Ona, V O, Li, M, Friedlander, R M

“…Caspase-1 plays an important functional role mediating neuronal cell death and dysfunction after experimental traumatic brain injury (TBI) in mice…”
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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease by Friedlander, Robert M, Chen, Minghua, Ona, Victor O, Li, Mingwei, Ferrante, Robert J, Fink, Klaus B, Zhu, Shan, Bian, Jie, Guo, Lei, Farrell, Laurie A, Hersch, Steve M, Hobbs, Wendy, Vonsattel, Jean-Paul, Cha, Jang-Ho J

“…Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline derivative with proven safety…”
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Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model by Li, Mingwei, Ona, Victor O., Guégan, Christelle, Chen, Minghua, Jackson-Lewis, Vernice, Andrews, L. John, Olszewski, Adam J., Stieg, Philip E., Jean-Pyo. Lee, Przedborski, Serge, Friedlander, Robert M.

“…Mutations in the copper/zinc Superoxide dismutase (SOD1) gene produce an animal model of familial amyotrophic lateral sclerosis (ALS), a fatal…”
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Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease by Zhang, Yu, Ona, Victor O., Li, Mingwei, Drozda, Martin, Dubois‐Dauphin, Michel, Przedborski, Serge, Ferrante, Robert J., Friedlander, Robert M.

“…Caspases play an important role in neurodegeneration in Huntington's disease (HD). Members of the Bcl‐2 family are critical modulators of terminal cell death…”
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Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease by Zhang, Yu, Ona, Victor O., Li, Mingwei, Drozda, Martin, Dubois‐Dauphin, Michel, Przedborski, Serge, Ferrante, Robert J., Friedlander, Robert M.

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