Outcomes of COVID-19 Critically Ill Extremely Elderly Patients: Analysis of a Large, National, Observational Cohort

During the COVID-19 pandemic, resource allocation became a major problem in globally overwhelmed ICUs. The main goal of this study was to describe the clinical characteristics of the very elderly patients (aged ≥ 80 years) with COVID-19 admitted in Romanian ICUs. The study objectives were to evaluat...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of clinical medicine Vol. 11; no. 6; p. 1544
Main Authors:	Andrei, Stefan, Valeanu, Liana, Stefan, Mihai Gabriel, Longrois, Dan, Popescu, Mihai, Stefan, Gabriel, Balan, Cosmin, Arafat, Raed, Corneci, Dan, Droc, Gabriela, Bubenek-Turconi, Serban-Ion, On Behalf Of The Covati-Ro Collaborative
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 11-03-2022 MDPI
Subjects:	Age Clinical medicine Coronaviruses COVID-19 Decision making Ethics Intensive care Medical prognosis Mortality Observational studies Pandemics Patients Principal components analysis Severe acute respiratory syndrome coronavirus 2 Variables Ventilators United States > US Romania COVID-19 mortality ICU mechanical ventilation outcomes elderly
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	During the COVID-19 pandemic, resource allocation became a major problem in globally overwhelmed ICUs. The main goal of this study was to describe the clinical characteristics of the very elderly patients (aged ≥ 80 years) with COVID-19 admitted in Romanian ICUs. The study objectives were to evaluate and determine the factors associated with ICU mortality. We designed a national, multicentric, observational platform with prospective enrolment. This study included patients aged ≥ 80 years admitted in Romanian ICUs with SARS-CoV-2 infection from March 2020 to December 2021. We included 1666 patients with a median age of 83 years and 78% ICU mortality. Male sex, dyspnoea, lower Glasgow Coma Scale and lower SpO2 at ICU admission, the need for mechanical ventilation (MV), and corticosteroid use were independently associated with mortality. A total of 886/1666 (53%) elderly patients underwent invasive mechanical ventilation, with a mortality of 97%. The age impact on mortality was confirmed by a 1:1 propensity matching with less elderly ICU patients. In extremely elderly patients with COVID-19 admitted in the ICU, mortality is high, particularly when requiring MV. Therapy should be directed towards the optimization of less invasive ventilatory methods and the use of MV and corticosteroids only in highly selected patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. Collaborators of the COVATI-RO Collaborative is provided in the Supplementary Material.
ISSN:	2077-0383 2077-0383
DOI:	10.3390/jcm11061544