Search Results - "Omura, Satoshi N"

Cryo-EM structure of the transposon-associated TnpB enzyme by Nakagawa, Ryoya, Hirano, Hisato, Omura, Satoshi N., Nety, Suchita, Kannan, Soumya, Altae-Tran, Han, Yao, Xiao, Sakaguchi, Yuriko, Ohira, Takayuki, Wu, Wen Y., Nakayama, Hiroshi, Shuto, Yutaro, Tanaka, Tatsuki, Sano, Fumiya K., Kusakizako, Tsukasa, Kise, Yoshiaki, Itoh, Yuzuru, Dohmae, Naoshi, van der Oost, John, Suzuki, Tsutomu, Zhang, Feng, Nureki, Osamu

“…The class 2 type V CRISPR effector Cas12 is thought to have evolved from the IS200/IS605 superfamily of transposon-associated TnpB proteins 1 . Recent studies…”
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An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis by Hino, Tomohiro, Omura, Satoshi N., Nakagawa, Ryoya, Togashi, Tomoki, Takeda, Satoru N., Hiramoto, Takafumi, Tasaka, Satoshi, Hirano, Hisato, Tokuyama, Takeshi, Uosaki, Hideki, Ishiguro, Soh, Kagieva, Madina, Yamano, Hiroyuki, Ozaki, Yuki, Motooka, Daisuke, Mori, Hideto, Kirita, Yuhei, Kise, Yoshiaki, Itoh, Yuzuru, Matoba, Satoaki, Aburatani, Hiroyuki, Yachie, Nozomu, Karvelis, Tautvydas, Siksnys, Virginijus, Ohmori, Tsukasa, Hoshino, Atsushi, Nureki, Osamu

“…SpCas9 and AsCas12a are widely utilized as genome-editing tools in human cells. However, their relatively large size poses a limitation for delivery by…”
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Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s? by Omura, Satoshi N, Nureki, Osamu

“…Fanzors are recently characterized RNA-guided DNA endonucleases found in eukaryotic organisms. In this issue of Cell, Xu, Saito et al. reveal the structural…”
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Structural basis for pegRNA-guided reverse transcription by a prime editor by Shuto, Yutaro, Nakagawa, Ryoya, Zhu, Shiyou, Hoki, Mizuki, Omura, Satoshi N., Hirano, Hisato, Itoh, Yuzuru, Zhang, Feng, Nureki, Osamu

“…The prime editor system composed of Streptococcus pyogenes Cas9 nickase (nSpCas9) and engineered Moloney murine leukaemia virus reverse transcriptase (M-MLV…”
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Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme by Omura, Satoshi N., Nakagawa, Ryoya, Südfeld, Christian, Villegas Warren, Ricardo, Wu, Wen Y., Hirano, Hisato, Laffeber, Charlie, Kusakizako, Tsukasa, Kise, Yoshiaki, Lebbink, Joyce H. G., Itoh, Yuzuru, van der Oost, John, Nureki, Osamu

“…RNA-guided type V CRISPR–Cas12 effectors provide adaptive immunity against mobile genetic elements (MGEs) in bacteria and archaea. Among diverse Cas12 enzymes,…”
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Cryo-EM structure of the transposonassociated TnpB enzyme by Nakagawa, Ryoya, Hirano, Hisato, Omura, Satoshi N, Nety, Suchita, Kannan, Soumya, Altae-Tran, Han, Yao, Xiao, Sakaguchi, Yuriko, Ohira, Takayuki, Wu, Wen Y, Nakayama, Hiroshi, Shuto, Yutaro, Tanaka, Tatsuki, Sano, Fumiya K, Kusakizako, Tsukasa, Kise, Yoshiaki, Itoh, Yuzuru, Dohmae, Naoshi, van der Oost, John, Suzuki, Tsutomu, Zhang, Feng, Nureki, Osamu

“…The class 2 type V CRISPR effector Cas12 is thought to have evolved from the 1S200/ 1S605 superfamily of transposon-associated TnpB proteins1. Recent studies…”
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