Search Results - "Omrane, Mohyeddine"

Triacylglycerols sequester monotopic membrane proteins to lipid droplets by Caillon, Lucie, Nieto, Vincent, Gehan, Pauline, Omrane, Mohyeddine, Rodriguez, Nicolas, Monticelli, Luca, Thiam, Abdou Rachid

“…Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into organelles called lipid droplets (LDs). LDs are covered by a…”
Get full text

Giant organelle vesicles to uncover intracellular membrane mechanics and plasticity by Santinho, Alexandre, Carpentier, Maxime, Lopes Sampaio, Julio, Omrane, Mohyeddine, Thiam, Abdou Rachid

“…Tools for accessing and studying organelles remain underdeveloped. Here, we present a method by which giant organelle vesicles (GOVs) are generated by…”
Get full text

Author Correction: Giant organelle vesicles to uncover intracellular membrane mechanics and plasticity by Santinho, Alexandre, Carpentier, Maxime, Lopes Sampaio, Julio, Omrane, Mohyeddine, Thiam, Abdou Rachid

Get full text

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols by Dumesnil, Calvin, Vanharanta, Lauri, Prasanna, Xavier, Omrane, Mohyeddine, Carpentier, Maxime, Bhapkar, Apoorva, Enkavi, Giray, Salo, Veijo T., Vattulainen, Ilpo, Ikonen, Elina, Thiam, Abdou Rachid

“…Cellular cholesterol can be metabolized to its fatty acid esters, cholesteryl esters (CEs), to be stored in lipid droplets (LDs). With triacylglycerols (TGs),…”
Get full text

ARL8B mediates lipid droplet contact and delivery to lysosomes for lipid remobilization by Menon, Dilip, Bhapkar, Apoorva, Manchandia, Bhoomika, Charak, Gitanjali, Rathore, Surabhi, Jha, Rakesh Mohan, Nahak, Arpita, Mondal, Moumita, Omrane, Mohyeddine, Bhaskar, Akash Kumar, Thukral, Lipi, Thiam, Abdou Rachid, Gandotra, Sheetal

“…Lipid droplets (LDs) play a crucial role in maintaining cellular lipid balance by storing and delivering lipids as needed. However, the intricate lipolytic…”
Get full text

Perilipin membrane integration determines lipid droplet heterogeneity in differentiating adipocytes by Majchrzak, Mario, Stojanović, Ozren, Ajjaji, Dalila, Ben M’barek, Kalthoum, Omrane, Mohyeddine, Thiam, Abdou Rachid, Klemm, Robin W.

“…The storage of fat within lipid droplets (LDs) of adipocytes is critical for whole-body health. Acute fatty acid (FA) uptake by differentiating adipocytes…”
Get full text

Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV by Akil, Abdellah, Peng, Juan, Omrane, Mohyeddine, Gondeau, Claire, Desterke, Christophe, Marin, Mickaël, Tronchère, Hélène, Taveneau, Cyntia, Sar, Sokhavuth, Briolotti, Philippe, Benjelloun, Soumaya, Benjouad, Abdelaziz, Maurel, Patrick, Thiers, Valérie, Bressanelli, Stéphane, Samuel, Didier, Bréchot, Christian, Gassama-Diagne, Ama

“…The accumulation of lipid droplets (LD) is frequently observed in hepatitis C virus (HCV) infection and represents an important risk factor for the development…”
Get full text

Septin 9 Orients the Apico-Basal Polarity Axis and Controls Plasticity Signals by Cai, Tingting, Peng, Juan, Omrane, Mohyeddine, Benzoubir, Nassima, Samuel, Didier, Gassama-Diagne, Ama

“…The cytoskeleton is a master organizer of the cellular cortex and membrane trafficking and therefore plays a crucial role in apico-basal polarity. Septins form…”
Get full text

Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets by Song, Pei Xuan, Peng, Juan, Omrane, Mohyeddine, Cai, Ting ting, Samuel, Didier, Gassama-Diagne, Ama

“…The accumulation of lipid droplets (LDs) in the liver is a hallmark of steatosis, which is often associated with lysosomal dysfunction. Nevertheless, the…”
Get full text

Septin 9 has Two Polybasic Domains Critical to Septin Filament Assembly and Golgi Integrity by Omrane, Mohyeddine, Camara, Amanda Souza, Taveneau, Cyntia, Benzoubir, Nassima, Tubiana, Thibault, Yu, Jinchao, Guérois, Raphaël, Samuel, Didier, Goud, Bruno, Poüs, Christian, Bressanelli, Stéphane, Garratt, Richard Charles, Thiam, Abdou Rachid, Gassama-Diagne, Ama

“…Septins are GTP-binding proteins involved in several membrane remodeling mechanisms. They associate with membranes, presumably using a polybasic domain (PB1)…”
Get full text

Septin 9 has Two Polybasic Domains Critical to Septin Filament Assembly and Golgi Integrity by Omrane, Mohyeddine, Camara, Amanda Souza, Taveneau, Cyntia, Benzoubir, Nassima, Tubiana, Thibault, Yu, Jinchao, Guérois, Raphaël, Samuel, Didier, Goud, Bruno, Poüs, Christian, Bressanelli, Stéphane, Garratt, Richard Charles, Thiam, Abdou Rachid, Gassama-Diagne, Ama

Get full text

Membrane Curvature Catalyzes Lipid Droplet Assembly by Santinho, Alexandre, Salo, Veijo T., Chorlay, Aymeric, Li, Shiqian, Zhou, Xin, Omrane, Mohyeddine, Ikonen, Elina, Thiam, Abdou Rachid

“…Lipid droplet (LD) biogenesis begins in the endoplasmic reticulum (ER) bilayer, but how the ER topology impacts this process is unclear. An early step in LD…”
Get full text

Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER by Chorlay, Aymeric, Monticelli, Luca, Veríssimo Ferreira, Joana, Ben M’barek, Kalthoum, Ajjaji, Dalila, Wang, Sihui, Johnson, Errin, Beck, Rainer, Omrane, Mohyeddine, Beller, Mathias, Carvalho, Pedro, Rachid Thiam, Abdou

“…During energy bursts, neutral lipids fabricated within the ER bilayer demix to form lipid droplets (LDs). LDs bud off mainly in the cytosol where they regulate…”
Get full text

LC3 conjugation to lipid droplets by Omrane, Mohyeddine, Melia, Thomas J., Thiam, Abdou Rachid

“…Macroautophagy/autophagy and lipid droplet (LD) biology are intricately linked, with autophagosome-dependent degradation of LDs in response to different…”
Get full text

ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites by Guyard, Valentin, Monteiro-Cardoso, Vera Filipa, Omrane, Mohyeddine, Sauvanet, Cécile, Houcine, Audrey, Boulogne, Claire, Ben Mbarek, Kalthoum, Vitale, Nicolas, Faklaris, Orestis, El Khallouki, Naima, Thiam, Abdou Rachid, Giordano, Francesca

“…Lipid droplets (LDs) are the primary organelles of lipid storage, buffering energy fluctuations of the cell. They store neutral lipids in their core that is…”
Get full text

LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy by Omrane, Mohyeddine, Ben M’Barek, Kalthoum, Santinho, Alexandre, Nguyen, Nathan, Nag, Shanta, Melia, Thomas J., Thiam, Abdou Rachid

“…Lipid droplets (LDs) store lipids that can be utilized during times of scarcity via autophagic and lysosomal pathways, but how LDs and autophagosomes interact…”
Get full text

HCV Core protein needs triacylglycerols to fold onto the endoplasmic reticulum membrane by Ajjaji, Dalila, M’barek, Kalthoum Ben, Boson, Bertrand, Omrane, Mohyeddine, Gassama‐diagne, Ama, Blaud, Magali, Penin, François, Diaz, Elise, Ducos, Bertrand, Cosset, François-Loïc, Thiam, Abdou Rachid

“…Lipid droplets (LDs) are involved in viral infections, but exactly how remains unclear. Here, we study the hepatitis C virus (HCV) whose Core capsid protein…”
Get full text

Hepatitis C virus core protein uses triacylglycerols to fold onto the endoplasmic reticulum membrane by Ajjaji, Dalila, Ben M'barek, Kalthoum, Boson, Bertrand, Omrane, Mohyeddine, Gassama‐Diagne, Ama, Blaud, Magali, Penin, François, Diaz, Elise, Ducos, Bertrand, Cosset, François‐Loïc, Thiam, Abdou Rachid

“…Lipid droplets (LDs) are involved in viral infections, but exactly how remains unclear. Here, we study the hepatitis C virus (HCV) whose core capsid protein…”
Get full text