Search Results - "Omran, Ziad"

Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors by Omran, Ziad

“…Aldehyde dehydrogenase-1a1 (ALDH1a1), the enzyme responsible for the oxidation of retinal into retinoic acid, represents a key therapeutic target for the…”
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New Disulfiram Derivatives as MAGL-Selective Inhibitors by Omran, Ziad

“…Monoacylglycerol lipase (MAGL) is a key enzyme in the human endocannabinoid system. It is also the main enzyme responsible for the conversion of 2-arachidonoyl…”
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Obesity: Current Treatment and Future Horizons by Omran, Ziad

“…Obesity is growing at an alarming rate with huge consequences on health and economy. The worldwide prevalence of obesity has nearly doubled in less than 35…”
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Anticancer Effects of New Disulfiram Analogs by Abdullah, Omeima, Beaudoin, Christopher A., Omran, Ziad

“…Disulfiram (DSF), an irreversible aldehyde dehydrogenase 2 (ALDH2) inhibitor, is an U.S. Food and Drug Administration (FDA)-approved drug for the treatment of…”
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Water-in-Oil Nano-Emulsions Prepared by Spontaneous Emulsification: New Insights on the Formulation Process by Akram, Salman, Anton, Nicolas, Omran, Ziad, Vandamme, Thierry

“…Nano-emulsions consist of stable suspensions of nano-scaled droplets that have huge loading capacities and are formulated with safe compounds. For these…”
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Design, Synthesis, and in Vitro Biological Evaluation of 14-Hydroxytylophorine-dichloroacetate Co-drugs as Antiproliferative Agents by Omran, Ziad, Alarja, Mohamed, Abdalla, Ashraf N., Ibrahim, Munjed M., Hossain, Mohammad A., Chen, Linwei, Liu, Yuxiu, Wang, Qingmin

“…Co-drug, or mutual-prodrug, is a drug design approach consisting of covalently linking two active drugs so as to improve the pharmacokinetics and/or…”
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Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer by Alhosin, Mahmoud, Omran, Ziad, Zamzami, Mazin A, Al-Malki, Abdulrahman L, Choudhry, Hani, Mousli, Marc, Bronner, Christian

“…Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and…”
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In Vitro and In Vivo Preventive Effects of Thymoquinone against Breast Cancer: Role of DNMT1 by Kaleem, Mohammed, Kayali, Asaad, Sheikh, Ryan A, Kuerban, Abudukadeer, Hassan, Mohammed A, Almalki, Naif Abdullah R, Al-Abbasi, Fahad A, Anwar, Firoz, Omran, Ziad, Alhosin, Mahmoud

“…Breast cancer (BC) is one of the most common cancers in women and is a major cause of female cancer-related deaths. BC is a multifactorial disease caused by…”
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Boronic Analogues of (R)-6-O-Desmethylantofine as Anticancer Agents by Omran, Ziad, Abdalla, Ashraf N., Ibrahim, Munjed M., Hossain, Mohammad A., Alarja, Mohamed, Chen, Linwei, Liu, Yuxiu, Wang, Qingmin

“…Phenanthroindolizidines are naturally occurring alkaloids mainly isolated from different species of Asclepiadaceae. These alkaloids are characterized by an…”
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A Fast Ubiquitination of UHRF1 Oncogene Is a Unique Feature and a Common Mechanism of Thymoquinone in Cancer Cells by Alhosin, Mahmoud, Abdullah, Omeima, Kayali, Asaad, Omran, Ziad

“…Downregulation of the ubiquitin-like containing PHD and ring finger 1 (UHRF1) oncogene in cancer cells in response to natural anticancer drugs, including…”
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The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer by Alsanosi, Safialdin, Sheikh, Ryan A, Sonbul, Sultan, Altayb, Hisham N, Batubara, Afnan S, Hosawi, Salman, Al-Sakkaf, Kaltoom, Abdullah, Omeima, Omran, Ziad, Alhosin, Mahmoud

“…oil, commonly known as black seed oil (BSO), is a well-known Mediterranean food, and its consumption is associated with beneficial effects on human health. A…”
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Concomitant analysis of dasatinib and curcuminoids in a pluronic-based nanoparticle formulation using a novel HPLC method by Alarjah, Mohammed A., Shahin, Mostafa H., Al-Azzah, Firas, Alarjah, Abdallah A., Omran, Ziad H.

“…A novel HPLC method was developed and validated to simultaneously determine curcuminoids and dasatinib in a new dosage form. Excellent separation was achieved…”
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Systematic Phytochemical Screening of Different Organs of Calotropis procera and the Ovicidal Effect of Their Extracts to the Foodstuff Pest Cadra cautella by Bader, Ammar, Omran, Ziad, Al-Asmari, Ahmed I, Santoro, Valentina, De Tommasi, Nunziatina, D'Ambola, Massimiliano, Dal Piaz, Fabrizio, Conti, Barbara, Bedini, Stefano, Halwani, Majed

“…In developing countries, crop deterioration is mainly caused by inappropriate storage conditions that promote insect infestation. Synthetic pesticides are…”
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Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents by Omran, Ziad, Guise, Chris P., Chen, Linwei, Rauch, Cyril, Abdalla, Ashraf N., Abdullah, Omeima, Sindi, Ikhlas A., Fischer, Peter M., Smaill, Jeff B., Patterson, Adam V., Liu, Yuxiu, Wang, Qingmin

“…Phenanthroindolizidines, such as antofine and tylophorine, are a family of natural alkaloids isolated from different species of Asclepiadaceas. They are…”
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Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors by Omran, Ziad, H Dalhat, Mahmood, Abdullah, Omeima, Kaleem, Mohammed, Hosawi, Salman, A Al-Abbasi, Fahd, Wu, Wei, Choudhry, Hani, Alhosin, Mahmoud

“…The tumor suppressor p73 is a member of the p53 family and is expressed as different isoforms with opposing properties. The TAp73 isoforms act as tumor…”
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Proton pump inhibitors for the treatment of cancer in companion animals by Walsh, Megan, Fais, Stefano, Spugnini, Enrico Pierluigi, Harguindey, Salvador, Abu Izneid, Tareq, Scacco, Licia, Williams, Paula, Allegrucci, Cinzia, Rauch, Cyril, Omran, Ziad

“…The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not…”
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Pinocytosis as the Biological Mechanism That Protects Pgp Function in Multidrug Resistant Cancer Cells and in Blood–Brain Barrier Endothelial Cells by Omran, Ziad, Whitehouse, Chloe, Halwani, Majed, Zamzami, Mazin A., Baothman, Othman A., Rauch, Cyril

“…Cancer is the second leading cause of death worldwide. Chemotherapy has shown reasonable success in treating cancer. However, multidrug resistance (MDR), a…”
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Development of new disulfiram analogues as ALDH1a1-selective inhibitors by Omran, Ziad

“…[Display omitted] Disulfiram is an FDA-approved drug used to treat chronic alcoholism. This drug works by blocking the second step of ethanol metabolism by…”
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Physics of the Chemical Asymmetry of the Cell Membrane: Implications in Gene Regulation and Pharmacology by Omran, Ziad, Williams, Paula, Rauch, Cyril

“…Signalling proteins are key regulators of basic cell physiology and tissues morphogenesis. Whilst signalling proteins are paramount for the cell to function…”
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Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy by Abdullah, Omeima, Omran, Ziad

“…Geldanamycin, an -macrolide composed of a rigid benzoquinone ring and an aliphatic -bridge, was isolated from . Geldanamycin is a potent heat shock protein…”
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