Search Results - "Omoruyi, Sylvester I."

Neuroprotective Activities of Boophone haemanthoides (Amaryllidaceae) Extract and Its Chemical Constituents by Ibrakaw, Abobaker S, Omoruyi, Sylvester I, Ekpo, Okobi E, Hussein, Ahmed A

“…Parkinson's disease (PD) is a neurodegenerative condition that progresses as age increases, and some of its major symptoms include tremor and postural and…”
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Neuroprotective Activities of Crossyne flava Bulbs and Amaryllidaceae Alkaloids: Implications for Parkinson’s Disease by Omoruyi, Sylvester I., Ibrakaw, Abobaker S., Ekpo, Okobi E., Boatwright, James S., Cupido, Christopher N., Hussein, Ahmed A.

“…Parkinson’s disease (PD) is one of the most common neurodegenerative diseases and affects approximately 6.3 million people worldwide. To date, the treatment of…”
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Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents by Mzezewa, Sheunopa C., Omoruyi, Sylvester I., Zondagh, Luke S., Malan, Sarel F., Ekpo, Okobi E., Joubert, Jacques

“…Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease (AD). Coumarin derivatives serve as a good starting…”
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4-Oxatricyclo[5.2.1.0 2,6 ]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential by Egunlusi, Ayodeji O, Malan, Sarel F, Omoruyi, Sylvester I, Ekpo, Okobi E, Joubert, Jacques

“…The impact of excitotoxicity mediated by -methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is…”
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Neuroprotective Effects of Glycyrrhiza glabra Total Extract and Isolated Compounds by Eltahir, Ali O E, Omoruyi, Sylvester I, Augustine, Tanya N, Luckay, Robert C, Hussein, Ahmed A

“…L. is a plant commonly utilized in herbal medicine and stands out as one of the more extensively researched medicinal plants globally. It has been documented…”
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Isolation of Lessertiosides A and B and Other Metabolites from Lessertia frutescens and Their Neuroprotection Activity by Ndjoubi, Kadidiatou O, Omoruyi, Sylvester I, Luckay, Robert C, Hussein, Ahmed A

“…Lessertia frutescens (synonym Sutherlandia frutescens) is an important South African medicinal plant used traditionally to treat different human pathologies…”
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Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents by Kapp, Erika, Visser, Hanri, Sampson, Samantha L, Malan, Sarel F, Streicher, Elizabeth M, Foka, Germaine B, Warner, Digby F, Omoruyi, Sylvester I, Enogieru, Adaze B, Ekpo, Okobi E, Zindo, Frank T, Joubert, Jacques

“…A medium-throughput screen using H37Rv was employed to screen an in-house library of structurally diverse compounds for antimycobacterial activity. In this…”
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Characterization and Toxicity of Hypoxoside Capped Silver Nanoparticles by Badeggi, Umar M, Omoruyi, Sylvester I, Ismail, Enas, Africa, Charlene, Botha, Subelia, Hussein, Ahmed A

“…The reducing potential of plant extracts in the green synthesis of nanoparticles has been associated with their phytochemicals. Although pharmacologically…”
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Open and rearranged norbornane derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP+- and calcium overload-induced excitotoxicity in neuroblastoma SH-SY5Y cells by Egunlusi, Ayodeji O., Malan, Sarel F., Omoruyi, Sylvester I., Ekpo, Okobi E., Palchykov, Vitalii A., Joubert, Jacques

“…The neuroprotective effects of closed polycyclic cage molecules such as NGP1-01, memantine and amantadine have been extensively explored. These effects are…”
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Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents by Zindo, Frank T., Malan, Sarel F., Omoruyi, Sylvester I., Enogieru, Adaze B., Ekpo, Okobi E., Joubert, Jacques

“…The multifactorial pathophysiology of neurodegenerative disorders remains one of the main challenges in the design of a single molecule that may ultimately…”
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Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease by Denya, Ireen, Malan, Sarel F, Enogieru, Adaze B, Omoruyi, Sylvester I, Ekpo, Okobi E, Kapp, Erika, Zindo, Frank T, Joubert, Jacques

“…A series of indole derivatives was designed and synthesised to improve on activity and circumvent pharmacokinetic limitations experienced with the structurally…”
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In vitro neuroprotective effects of boophone disticha, brunsvigia bosmaniae and strumaria truncata extracts in SH-SY5Y cells by Kangwa, Tusekile S., Hiss, Donavon C., Hussein, Ahmed A., Ekpo, Okobi E., Omoruyi, Sylvester I.

“…•Extracts of boophone disticha, brunsvigia bosmaniae and strumaria truncata protect SH-SY5Y cells from MPP+-induced neurotoxicity is SH-SY5Y cells.•Extracts of…”
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Aspalathin and linearthin from Aspalathus linearis (Rooibos) protect SH-SY5Y cells from MPP+-induced neuronal toxicity by Omoruyi, Sylvester I., Akinfenwa, Akeem O., Ekpo, Okobi E., Hussein, Ahmed A.

“…•Aspalathus linearis and its bioactive compounds aspalathin and linearthin protect SH-SY5Y cells from MPP+-induced neurotoxicity is SH-SY5Y cells.•Aspalathus…”
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Aqueous leaf extract of Sutherlandia frutescens attenuates ROS-induced apoptosis and loss of mitochondrial membrane potential in MPP+-treated SH-SY5Y cells by Enogieru, Adaze B., Omoruyi, Sylvester I., Ekpo, Okobi E.

“…Purpose: To investigate the neuroprotective activity of the aqueous extract of Sutherlandia frutescens (SF) against 1-methyl-4-phenylpyridinium (MPP+)-induced…”
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The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus by Omolaja, Akinfenwa A., Pearce, Brendon, Omoruyi, Sylvester I., Badmus, Jelili A., Ismail, Enas, Marnewick, Jeanine, Botha, Subelia, Benjeddou, Mongi, Ekpo, Okobi E., Hussein, Ahmed A.

“…•Two chalcones were successfully isolated and identified from H.foetidum.•The activities of the total extract and the chalcones were explored for the…”
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Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer's disease agents by Mzezewa, Sheunopa C., Omoruyi, Sylvester I., Zondagh, Luke S., Malan, Sarel F., Ekpo, Okobi E., Joubert, Jacques

“…Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer's disease (AD). Coumarin derivatives serve as a good starting…”
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