Search Results - "Omoboyowa, Damilola A."

Unveiling the Chemical Profiling Antioxidant and Anti-Inflammatory Activities of Algerian Myrtus communis L. Essential Oils, and Exploring Molecular Docking to Predict the Inhibitory Compounds against Cyclooxygenase-2 by Belahcene, Samia, Kebsa, Widad, Omoboyowa, Damilola A., Alshihri, Abdulaziz A., Alelyani, Magbool, Bakkour, Youssef, Leghouchi, Essaid

“…Considering the large spectrum of side effects caused by synthetic drugs and the development of natural alternatives utilizing Algerian flora, this study aimed…”
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Antidiabetes study of Spondias mombin (Linn) stem bark fractions in high-sucrose diet-induced diabetes in Drosophila melanogaster by Omoboyowa, Damilola A, Agoi, Mary D, Shodehinde, Sidiqat A, Saibu, Oluwatosin A, Saliu, Jamiyu A

“…The onset of insulin resistant diabetes has been associated with a high-sucrose diet in vertebrates and invertebrates. However, various parts of reportedly…”
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In vitro antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids by Oyeneyin, Oluwatoba E., Moodley, Rashmika, Mashaba, Chakes, Garnie, Larnelle F., Omoboyowa, Damilola A., Rakodi, Goitsemodimo H., Maphoru, Mabuatsela V., Balogun, Mohamed O., Hoppe, Heinrich C., Egan, Timothy J., Tukulula, Matshawandile

“…Quinoline-urea-benzothiazole hybrids exhibited low to sub-micromolar in vitro activities against the Plasmodium falciparum (P. falciparum) 3D7 chloroquine…”
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Receptor tyrosine kinases as a therapeutic target by natural compounds in cancer treatment by Balogun, Toheeb A., Ige, Oluwasegun M., Alausa, Abdullahi O., Onyeani, Chijioke O., Tiamiyu, Zainab A., Omoboyowa, Damilola A., Saibu, Oluwatosin A., Abdullateef, Olayemi T.

“…Background Receptor tyrosine kinases (RTKs) are single-pass transmembrane proteins that play significant roles in regulating cellular processes, including cell…”
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Vitellaria paradoxa inhibits arsenic-induced toxicity in Drosophila melanogaster via the augmentation of antioxidant system by Oyibo, Aghogho, Abolaji, Amos O., Omoboyowa, Damilola A., Odunola, Oyeronke A.

“…The Ethyl Acetate Fraction (EACF) of Ethanol Leaf Extract of Vitellaria paradoxa (ELVp) was assessed against Sodium Arsenite (SA)-induced toxicity in…”
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Computational investigation of phytochemicals from Abrus precatorius seeds as modulators of peroxisome proliferator-activated receptor gamma (PPARγ) by Omoboyowa, Damilola A., Singh, Gagandeep, Fatoki, John O., Oyeneyin, Oluwatoba E.

“…Type 2 diabetes mellitus remains global health challenge with involvement of both insulin resistance and dysfunctional insulin secretion from the pancreatic…”
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Computational prediction of 11β-hydroxysteroid dehydrogenase inhibitors from n-butanol fraction of Blighia welwetschii (Hiern) leaf for the management of type-2 diabetes by Aribigbola, Temitope C., Omoboyowa, Damilola A., Bodun, Damilola S.

“…Human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an enzyme that catalyzes the generation of active cortisol from cortisone, thus regulating the…”
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Design of small molecules for CDK-2 inhibition in colorectal cancer based on substructure search by Ogbodo, Uchechukwu C, Salimat, Sofela, Bodun, Damilola S, Balogun, Toheeb A, Omoboyowa, Damilola A

“…The global frequency of colorectal cancer motivates extensive drug discovery efforts. CDK2, a key member of the CDK family, has been linked to tumor…”
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Virtual screening and molecular dynamics simulation of natural compounds as potential inhibitors of serine/threonine kinase 16 for anticancer drug discovery by Al-Fahad, Dhurgham, Ropón-Palacios, G, Omoboyowa, Damilola A, Singh, Gagandeep, Patil, Rajesh B

“…Serine/threonine kinase 16 (STK 16) is involved in many facets of cellular regulation; activation of STK 16 plays a crucial role in the migration of cancer…”
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Identification of HER2 inhibitors from curcumin derivatives using combination of in silico screening and molecular dynamics simulation by Saibu, Oluwatosin A., Singh, Gagandeep, Olugbodi, Sunday A., Oluwafemi, Adenrele T., Ajayi, Temitope M., Hammed, Sodiq O., Oladipo, Oladapo O., Odunitan, Tope T., Omoboyowa, Damilola A.

“…Breast cancer remains a major world health challenge in women. Some Breast cancers are human epidermal growth factor receptor 2 (HER2) positive. Since this…”
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Protein-protein interaction and interference of carcinogenesis by supramolecular modifications by Saibu, Oluwatosin A., Hammed, Sodiq O., Oladipo, Oladapo O., Odunitan, Tope T., Ajayi, Temitope M., Adejuyigbe, Aderonke J., Apanisile, Boluwatife T., Oyeneyin, Oluwatoba E., Oluwafemi, Adenrele T., Ayoola, Tolulope, Olaoba, Olamide T., Alausa, Abdullahi O., Omoboyowa, Damilola A.

“…[Display omitted] Protein-protein interactions (PPIs) are essential in normal biological processes, but they can become disrupted or imbalanced in cancer…”
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Investigating the effect of 1,2-Dibenzoylhydrazine on Staphylococcus aureus using integrated computational approaches by Oluwafemi, Kola A., Jimoh, Rashidat B., Omoboyowa, Damilola A., Olonisakin, Adebisi, Adeforiti, Anthony F., Iqbal, Naveed

“…Staphylococcus aureus , a notorious member of the ESKAPE pathogens, poses significant public health challenges due to its virulence and multidrug-resistant…”
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QSAR-based virtual screening of traditional Chinese medicine for the identification of mitotic kinesin Eg5 inhibitors by Bodun, Damilola S., Omoboyowa, Damilola A., Omotuyi, Olaposi I., Olugbogi, Ezekiel A., Balogun, Toheeb A., Ezeh, Chiamaka J., Omirin, Emmanuel S.

“…Cell division is a crucial process for the growth and development of all living organisms. Unfortunately, uncontrolled cell division and growth is a hallmark…”
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Structure-based in silico investigation of antagonists of human ribonucleotide reductase from Annona muricata by Omoboyowa, Damilola A., Bodun, Damilola S., Saliu, Jamiyu A.

“…Human ribonucleotide reductase (HRR) also known as ribonuceotide diphosphate reductase catalyzes the conversion of ribonucleotide to deoxyribonuceotides which…”
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Integrating biocomputational techniques for Breast cancer drug discovery via the HER-2, BCRA, VEGF and ER protein targets by Odunitan, Tope T, Saibu, Oluwatosin A, Apanisile, Boluwatife T, Omoboyowa, Damilola A, Balogun, Toheeb A, Awe, Adeyoola V, Ajayi, Temitope M, Olagunju, Grace V, Mahmoud, Fatimah M, Akinboade, Modinat, Adeniji, Catherine B, Abdulazeez, Waliu O

“…Computational modelling remains an indispensable technique in drug discovery. With myriad of high computing resources, and improved modelling algorithms, there…”
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Nephro-protective efficacy of Blighia sapida stem bark ether fractions on experimentally induced diabetes nephropathy by Omoboyowa, Damilola A., Karigidi, Kayode O., Aribigbola, Temitope C.

“…Studies suggest that Blighia sapida ( B. sapida ) possesses hypoglycemic potential. The potentials of B. sapida to ameliorate diabetic complications including…”
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Computational Evaluation of Bioactive Compounds from Colocasia affinis Schott as a Novel EGFR Inhibitor for Cancer Treatment by Balogun, Toheeb A, Ipinloju, Nureni, Abdullateef, Olayemi T, Moses, Segun I, Omoboyowa, Damilola A, James, Akinwumi C, Saibu, Oluwatosin A, Akinyemi, Wumi F, Oni, Ebenezer A

“…Introduction: Epidermal growth factor receptor (EGFR) is a transmembrane protein that belongs to the ErbB/HER-family of tyrosine kinase receptors. Somatic…”
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Molecular mechanics and dynamics simulation of CD-47/SIRPα blockade study: A computational study on overcoming immunotherapeutic resistance in pancreatic ductal adenocarcinoma by Saibu, Oluwatosin A., Ajayi, Temitope M., Omoboyowa, Damilola A., Oladipo, Oladapo O., Hammed, Sodiq O., Odunitan, Tope T., Oluwafemi, Adenrele T., Adejuyigbe, Aderonke J., Aloba, Gideon O., Balogun, Toheeb A., O.Alausa, Abdullahi, Bodun, Damilola S.

“…The sting of pancreatic ductal adenocarcinoma remains an irksome burden to the human populace. The focus of recent research has switched from finding the…”
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Virtual screening for novel FGFR2 inhibitors: Exploring Gefitinib-like compounds as promising therapeutic candidates by Sofela, Salimat O., Bodun, Damilola S., Omoboyowa, Damilola A., Ajiboro, Precious A., Nwankwo, Daniel O., Ashimiyu-Abdusalam, Zainab, Issac, Ibidun B., Abdulrasheed, Buhari, Balogun, Toheeb A., Ajayi, Ifetayo H.

“…Gefitinib, an established anticancer medication targeting Epidermal Growth Factor Receptor (EGFR), has faced challenges due to tumor resistance and relapse…”
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Modulatory effects of selected compounds on oxidative stress in hydrogen peroxide-induced Drosophila melanogaster by Omoboyowa, Damilola A., Olugbenga, Samuel T., Adetuyi, Faith D., Akinsulure, Simbo T., Akinwande, Kehinde M., Iwuji, Chimaobi B., Ayekolu, Susan F.

“…The balance between oxidant production and their conversion to harmless products is vital to the survival of living organisms. Hence the comparative free…”
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