Search Results - "Omichinski, James"

Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors by Kamada, Rui, Kudoh, Fuki, Ito, Shogo, Tani, Itsumi, Janairo, Jose Isagani B., Omichinski, James G., Sakaguchi, Kazuyasu

“…Protein phosphatases and kinases control multiple cellular events including proliferation, differentiation, and stress responses through regulating reversible…”
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Peroxisome biogenesis initiated by protein phase separation by Ravindran, Rini, Bacellar, Isabel O. L., Castellanos-Girouard, Xavier, Wahba, Haytham M., Zhang, Zhenghao, Omichinski, James G., Kisley, Lydia, Michnick, Stephen W.

“…Peroxisomes are organelles that carry out β-oxidation of fatty acids and amino acids. Both rare and prevalent diseases are caused by their dysfunction 1 …”
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Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1 by Lussier-Price, Mathieu, Wahba, Haytham M, Mascle, Xavier H, Cappadocia, Laurent, Bourdeau, Veronique, Gagnon, Christina, Igelmann, Sebastian, Sakaguchi, Kazuyasu, Ferbeyre, Gerardo, Omichinski, James G

“…Abstract SUMO proteins are important regulators of many key cellular functions in part through their ability to form interactions with other proteins…”
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Pax7 pioneer factor action requires both paired and homeo DNA binding domains by Pelletier, Audrey, Mayran, Alexandre, Gouhier, Arthur, Omichinski, James G, Balsalobre, Aurelio, Drouin, Jacques

“…Abstract The pioneer transcription factor Pax7 contains two DNA binding domains (DBD), a paired and a homeo domain. Previous work on Pax7 and the related Pax3…”
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Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR by Ali, Mohamed G., Wahba, Haytham M., Igelmann, Sebastian, Cyr, Normand, Ferbeyre, Gerardo, Omichinski, James G.

“…The Atg8-family proteins (MAP1LC3/LC3A, LC3B, LC3C, GABARAP, GABARAPL1 and GABARAPL2) play a pivotal role in macroautophagy/autophagy through their ability to…”
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Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-κB and transcription regulatory factors by Lecoq, Lauriane, Raiola, Luca, Chabot, Philippe R, Cyr, Normand, Arseneault, Geneviève, Legault, Pascale, Omichinski, James G

“…p65 is a member of the NF-κB family of transcriptional regulatory proteins that functions as the activating component of the p65-p50 heterodimer. Through its…”
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The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein by Nakagawa, Natsumi, Sakaguchi, Shuya, Nomura, Takao, Kamada, Rui, Omichinski, James G., Sakaguchi, Kazuyasu

“…The p53 protein plays a number of roles in protecting organisms from different genotoxic stresses and this includes DNA damage induced by acetaldehyde, a…”
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Highly Similar Tetramerization Domains from the p53 Protein of Different Mammalian Species Possess Varying Biophysical, Functional and Structural Properties by Sakaguchi, Shuya, Nakagawa, Natsumi, Wahba, Haytham M, Wada, Junya, Kamada, Rui, Omichinski, James G, Sakaguchi, Kazuyasu

“…The p53 protein is a transcriptional regulatory factor and many of its functions require that it forms a tetrameric structure. Although the tetramerization…”
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Role of active site arginine residues in substrate recognition by PPM1A by Tani, Itsumi, Ito, Shogo, Shirahata, Yukiko, Matsuyama, Yutaka, Omichinski, James G., Shimohigashi, Yasuyuki, Kamada, Rui, Sakaguchi, Kazuyasu

“…Reversible protein phosphorylation is a key mechanism for regulating numerous cellular events. The metal-dependent protein phosphatases (PPM) are a family of…”
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Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner by Mascle, Xavier H., Gagnon, Christina, Wahba, Haytham M., Lussier-Price, Mathieu, Cappadocia, Laurent, Sakaguchi, Kazuyasu, Omichinski, James G.

“…The interactions between SUMO proteins and SUMO-interacting motif (SIM) in nuclear bodies formed by the promyelocytic leukemia (PML) protein (PML-NBs) have…”
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Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1 by Cappadocia, Laurent, Mascle, Xavier H., Bourdeau, Véronique, Tremblay-Belzile, Samuel, Chaker-Margot, Malik, Lussier-Price, Mathieu, Wada, Junya, Sakaguchi, Kazuyasu, Aubry, Muriel, Ferbeyre, Gerardo, Omichinski, James G.

“…PML and several other proteins localizing in PML-nuclear bodies (PML-NB) contain phosphoSIMs (SUMO-interacting motifs), and phosphorylation of this motif plays…”
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Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins by Lussier-Price, Mathieu, Mascle, Xavier H., Cappadocia, Laurent, Kamada, Rui, Sakaguchi, Kazuyasu, Wahba, Haytham M., Omichinski, James G.

“…The human PIAS proteins are small ubiquitin-like modifier (SUMO) E3 ligases that participate in important cellular functions. Several of these functions depend…”
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Structural and functional characterization of a complex between the acidic transactivation domain of EBNA2 and the Tfb1/p62 subunit of TFIIH by Chabot, Philippe R, Raiola, Luca, Lussier-Price, Mathieu, Morse, Thomas, Arseneault, Genevieve, Archambault, Jacques, Omichinski, James G

“…Infection with the Epstein-Barr virus (EBV) can lead to a number of human diseases including Hodgkin's and Burkitt's lymphomas. The development of these…”
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MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells by Bottardi, Stefania, Guieze, Romain, Bourgoin, Vincent, Fotouhi-Ardakani, Nasser, Dougé, Aurore, Darracq, Anaïs, Lakehal, Yahia A., Berger, Marc G., Mollica, Luigina, Bay, Jacques-Olivier, Omichinski, James G., Milot, Eric

“…•MNDA downregulates MCL-1 and BCL-2 in lymphoid cells.•MNDA is associated with (pre)mRNA.•MNDA is recruited to gene regulatory regions. The myeloid nuclear…”
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A hydride transfer complex reprograms NAD metabolism and bypasses senescence by Igelmann, Sebastian, Lessard, Frédéric, Uchenunu, Oro, Bouchard, Jacob, Fernandez-Ruiz, Ana, Rowell, Marie-Camille, Lopes-Paciencia, Stéphane, Papadopoli, David, Fouillen, Aurélien, Ponce, Katia Julissa, Huot, Geneviève, Mignacca, Lian, Benfdil, Mehdi, Kalegari, Paloma, Wahba, Haytham M., Pencik, Jan, Vuong, Nhung, Quenneville, Jordan, Guillon, Jordan, Bourdeau, Véronique, Hulea, Laura, Gagnon, Etienne, Kenner, Lukas, Moriggl, Richard, Nanci, Antonio, Pollak, Michael N., Omichinski, James G., Topisirovic, Ivan, Ferbeyre, Gerardo

“…Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly…”
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Unorthodox PCNA Binding by Chromatin Assembly Factor 1 by Gopinathan Nair, Amogh, Rabas, Nick, Lejon, Sara, Homiski, Caleb, Osborne, Michael J, Cyr, Normand, Sverzhinsky, Aleksandr, Melendy, Thomas, Pascal, John M, Laue, Ernest D, Borden, Katherine L B, Omichinski, James G, Verreault, Alain

“…The eukaryotic DNA replication fork is a hub of enzymes that continuously act to synthesize DNA, propagate DNA methylation and other epigenetic marks, perform…”
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Monomer‐to‐dimer transition of Brucella suis type IV secretion system component VirB8 induces conformational changes by Sharifahmadian, Mahzad, Arya, Tarun, Bessette, Benoit, Lecoq, Lauriane, Ruediger, Edward, Omichinski, James G., Baron, Christian

“…Secretion systems are protein complexes essential for bacterial virulence and potential targets for antivirulence drugs. In the intracellular pathogen…”
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The type IV secretion system core component VirB8 interacts via the β1‐strand with VirB10 by Sharifahmadian, Mahzad, Nlend, Ingrid U., Lecoq, Lauriane, Omichinski, James G., Baron, Christian

“…In this work, we provide evidence for the interactions between VirB8 and VirB10, two core components of the type IV secretion system (T4SS). Using nuclear…”
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ΩXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence by Cyr, Normand, de la Fuente, Cynthia, Lecoq, Lauriane, Guendel, Irene, Chabot, Philippe R., Kehn-Hall, Kylene, Omichinski, James G.

“…Significance Infection with the Rift Valley fever virus (RVFV) has the capacity to cause fatal hemorrhagic fever in humans. A unique characteristic of RVFV…”
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Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch by Desrochers, Guillaume, Cappadocia, Laurent, Lussier-Price, Mathieu, Ton, Anh-Tien, Ayoubi, Riham, Serohijos, Adrian, Omichinski, James G., Angers, Annie

“…The ligase Itch plays major roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrates. Substrate recognition and…”
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