Community spread of extended-spectrum β-lactamase-producing bacteria detected in social insurance hospitals throughout Japan

Community spread of extended-spectrum β-lactamase-producing bacteria detected in social insurance hospitals throughout Japan

Abstract We surveyed the status of community-acquired infections involving four extended-spectrum β-lactamase (ESBL)-producing bacteria ( Escherichia coli , Klebsiella pneumoniae , Klebsiella oxytoca , Proteus mirabilis ) isolated from clinical specimens from 11 social insurance hospitals in Japan i...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 22; no. 6; pp. 395 - 399
Main Authors: Shibasaki, Mayumi, Komatsu, Masaru, Sueyoshi, Noriyuki, Maeda, Misaho, Uchida, Takae, Yonezawa, Hitoshi, Inagaki, Kenji, Omi, Ayako, Matsumoto, Hidenobu, Murotani, Makiko, Iwamoto, Tsukasa, Kodaka, Yoshihiro, Kieda, Hideto, Tokiwa, Manabu, Masuwa, Bunji, Kinoshita, Mari, Saito, Kazuei, Katou, Masahiko
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01-06-2016
Subjects:
Adult
Aged
Aged, 80 and over
beta-Lactamases - biosynthesis
Child
Community-Acquired Infections - microbiology
DNA Fingerprinting
Enterobacteriaceae
Enterobacteriaceae - enzymology
Enterobacteriaceae - genetics
Enterobacteriaceae - isolation & purification
ESBL
Escherichia coli
Genotype
Hematology, Oncology and Palliative Medicine
Hospitals, Community
Humans
Infant
Japan
Klebsiella oxytoca
Klebsiella pneumoniae
Middle Aged
PCR
Proteus mirabilis
Social Security
Surveillance
Young Adult
ESBL
Surveillance
PCR
Enterobacteriaceae
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Summary:Abstract We surveyed the status of community-acquired infections involving four extended-spectrum β-lactamase (ESBL)-producing bacteria ( Escherichia coli , Klebsiella pneumoniae , Klebsiella oxytoca , Proteus mirabilis ) isolated from clinical specimens from 11 social insurance hospitals in Japan in 2012. These are member hospitals of the Japan Community Healthcare Organization, an independent administrative hospital organization. The isolation rates for E. coli , K. pneumoniae , K. oxytoca , and P. mirabilis were 14.0% (165/1176), 3.3% (16/480), 3.1% (4/130), and 15.9% (17/107), respectively. The CTX-M-9 group, the most frequently detected genotype, was found in 77.0% (127/165) of E. coli and 43.8% (7/16) of K. pneumoniae isolates. Among K. oxytoca isolates, 75% (3/4) were the CTX-M-1 group, and all 17 P. mirabilis strains were the CTX-M-2 group. ESBL-producing bacteria isolation rates in each hospital ranged from 5.8% to 21.5% (median 9.5%), and the proportion of community-acquired infections among ESBL-producing bacteria isolates ranged from 1.6% to 30.8% (median 11.4%) in each hospital. Overall, the rates of ESBL-producing bacterial infection in all community-acquired infections and in all hospital infections were 10.6% (115/1081) and 10.7% (87/812), respectively. The ESBL-producing bacteria are not limited to certain regions or hospitals but are spreading in communities throughout Japan.
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ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2016.03.001