Search Results - "Omari, Sofia A."

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice by Boast, Brigette, Miosge, Lisa A, Kuehn, Hye Sun, Cho, Vicky, Athanasopoulos, Vicki, McNamara, Hayley A, Sontani, Yovina, Mei, Yan, Howard, Debbie, Sutton, Henry J, Omari, Sofia A, Yu, Zhijia, Nasreen, Mariam, Andrews, T Daniel, Cockburn, Ian A, Goodnow, Christopher C, Rosenzweig, Sergio D, Enders, Anselm

“…IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous mouse models have demonstrated the dual role for IKZF1 in both B and T…”
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In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia by Omari, Sofia A., Kosasih, Hansen J., Chung, Thomas, de Bock, Charles E.

“…Mutations within the IL7-R-JAK-STAT signaling pathway are important drivers of T-cell acute lymphoblastic leukemia (T-ALL). Here we describe the important…”
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TRPV1 Channels in Immune Cells and Hematological Malignancies by Omari, Sofia A, Adams, Murray J, Geraghty, Dominic P

“…Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical…”
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Optimized flow cytometric detection of transient receptor potential vanilloid-1 (TRPV1) in human hematological malignancies by Omari, Sofia A., Geraghty, Dominic P., Khalafallah, Alhossain A., Venkat, Pooja, Shegog, Yvette M., Ragg, Scott J., de Bock, Charles E., Adams, Murray J.

“…The ectopic overexpression of transient receptor potential vanilloid-1 (TRPV1) has been detected in numerous solid cancers, including breast, prostate,…”
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Capsaicin-Induced Death of Human Haematological Malignant Cell Lines Is Independent of TRPV1 Activation by Omari, Sofia A, Adams, Murray J, Kunde, Dale A, Geraghty, Dominic P

“…The effect of the plant-derived vanilloid, capsaicin (CAP), on the metabolic activity of THP-1, U266B1 and U937 hematological malignancy cells was determined…”
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