Search Results - "Omar, Rumana"

Methods to adjust for multiple comparisons in the analysis and sample size calculation of randomised controlled trials with multiple primary outcomes by Vickerstaff, Victoria, Omar, Rumana Z, Ambler, Gareth

“…Multiple primary outcomes may be specified in randomised controlled trials (RCTs). When analysing multiple outcomes it's important to control the family wise…”
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Review and evaluation of penalised regression methods for risk prediction in low-dimensional data with few events by Pavlou, Menelaos, Ambler, Gareth, Seaman, Shaun, De Iorio, Maria, Omar, Rumana Z

“…Risk prediction models are used to predict a clinical outcome for patients using a set of predictors. We focus on predicting low‐dimensional binary outcomes…”
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How to develop a more accurate risk prediction model when there are few events by Pavlou, Menelaos, Ambler, Gareth, Seaman, Shaun R, Guttmann, Oliver, Elliott, Perry, King, Michael, Omar, Rumana Z

“…When the number of events is low relative to the number of predictors, standard regression could produce overfitted risk models that make inaccurate…”
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Seroprevalence of SARS-CoV-2 antibodies in people with an acute loss in their sense of smell and/or taste in a community-based population in London, UK: An observational cohort study by Makaronidis, Janine, Mok, Jessica, Balogun, Nyaladzi, Magee, Cormac G, Omar, Rumana Z, Carnemolla, Alisia, Batterham, Rachel L

“…Loss of smell and taste are commonly reported symptoms associated with coronavirus disease 2019 (COVID-19); however, the seroprevalence of severe acute…”
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A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD) by O'Mahony, Constantinos, Jichi, Fatima, Pavlou, Menelaos, Monserrat, Lorenzo, Anastasakis, Aristides, Rapezzi, Claudio, Biagini, Elena, Gimeno, Juan Ramon, Limongelli, Giuseppe, McKenna, William J, Omar, Rumana Z, Elliott, Perry M

“…Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death (SCD) in young adults. Current risk algorithms provide only a crude estimate of…”
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Penalized Regression Methods With Modified Cross‐Validation and Bootstrap Tuning Produce Better Prediction Models by Pavlou, Menelaos, Omar, Rumana Z., Ambler, Gareth

“…ABSTRACT Risk prediction models fitted using maximum likelihood estimation (MLE) are often overfitted resulting in predictions that are too extreme and a…”
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Non-pharmacological interventions for agitation in dementia: systematic review of randomised controlled trials by Livingston, Gill, Kelly, Lynsey, Lewis-Holmes, Elanor, Baio, Gianluca, Morris, Stephen, Patel, Nishma, Omar, Rumana Z., Katona, Cornelius, Cooper, Claudia

“…Agitation in dementia is common, persistent and distressing and can lead to care breakdown. Medication is often ineffective and harmful. To systematically…”
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Sample size calculation for a stepped wedge trial by Baio, Gianluca, Copas, Andrew, Ambler, Gareth, Hargreaves, James, Beard, Emma, Omar, Rumana Z

“…Stepped wedge trials (SWTs) can be considered as a variant of a clustered randomised trial, although in many ways they embed additional complications from the…”
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Living and dying with advanced dementia: A prospective cohort study of symptoms, service use and care at the end of life by Sampson, Elizabeth L, Candy, Bridget, Davis, Sarah, Gola, Anna Buylova, Harrington, Jane, King, Michael, Kupeli, Nuriye, Leavey, Gerry, Moore, Kirsten, Nazareth, Irwin, Omar, Rumana Z, Vickerstaff, Victoria, Jones, Louise

“…Background: Increasing number of people are dying with advanced dementia. Comfort and quality of life are key goals of care. Aims: To describe (1) physical and…”
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The accuracy of clinician predictions of survival in the Prognosis in Palliative care Study II (PiPS2): A prospective observational study by Stone, Patrick C, Chu, Christina, Todd, Chris, Griffiths, Jane, Kalpakidou, Anastasia, Keeley, Vaughan, Omar, Rumana Z, Vickerstaff, Victoria

“…Prognostic information is important for patients with cancer, their families, and clinicians. In practice, survival predictions are made by clinicians based on…”
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A comparison of methods for analysing multiple outcome measures in randomised controlled trials using a simulation study by Vickerstaff, Victoria, Ambler, Gareth, Omar, Rumana Z.

“…Multiple primary outcomes are sometimes collected and analysed in randomised controlled trials (RCTs), and are used in favour of a single outcome. By…”
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A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia by Livingston, Gill, Kelly, Lynsey, Lewis-Holmes, Elanor, Baio, Gianluca, Morris, Stephen, Patel, Nishma, Omar, Rumana Z, Katona, Cornelius, Cooper, Claudia

“…Agitation is common, persistent and distressing in dementia and is linked with care breakdown. Psychotropic medication is often ineffective or harmful, but the…”
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Cerebral Magnetic Resonance Biomarkers in Neonatal Encephalopathy: A Meta-analysis by Thayyil, Sudhin, Chandrasekaran, Manigandan, Taylor, Andrew, Bainbridge, Alan, Cady, Ernest B, Chong, W. K. Kling, Murad, Shahed, Omar, Rumana Z, Robertson, Nicola J

“…Accurate prediction of neurodevelopmental outcome in neonatal encephalopathy (NE) is important for clinical management and to evaluate neuroprotective…”
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Risk prediction in multicentre studies when there is confounding by cluster or informative cluster size by Pavlou, Menelaos, Ambler, Gareth, Omar, Rumana Z

“…Abstract Background Clustered data arise in research when patients are clustered within larger units. Generalised Estimating Equations (GEE) and Generalised…”
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Review and evaluation of performance measures for survival prediction models in external validation settings by Rahman, M Shafiqur, Ambler, Gareth, Choodari-Oskooei, Babak, Omar, Rumana Z

“…When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance…”
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An evaluation of sample size requirements for developing risk prediction models with binary outcomes by Pavlou, Menelaos, Ambler, Gareth, Qu, Chen, Seaman, Shaun R, White, Ian R, Omar, Rumana Z

“…Risk prediction models are routinely used to assist in clinical decision making. A small sample size for model development can compromise model performance…”
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Clinical outcomes of staff training in positive behaviour support to reduce challenging behaviour in adults with intellectual disability: cluster randomised controlled trial by Hassiotis, Angela, Poppe, Michaela, Strydom, Andre, Vickerstaff, Victoria, Hall, Ian S., Crabtree, Jason, Omar, Rumana Z., King, Michael, Hunter, Rachael, Biswas, Asit, Cooper, Viv, Howie, William, Crawford, Michael J.

“…Staff training in positive behaviour support (PBS) is a widespread treatment approach for challenging behaviour in adults with intellectual disability. Aims To…”
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International External Validation Study of the 2014 European Society of Cardiology Guidelines on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy (EVIDENCE-HCM) by O’Mahony, Constantinos, Jichi, Fatima, Ommen, Steve R, Christiaans, Imke, Arbustini, Eloisa, Garcia-Pavia, Pablo, Cecchi, Franco, Olivotto, Iacopo, Kitaoka, Hiroaki, Gotsman, Israel, Carr-White, Gerald, Mogensen, Jens, Antoniades, Loizos, Mohiddin, Saidi A, Maurer, Mathew S, Tang, Hak Chiaw, Geske, Jeffrey B, Siontis, Konstantinos C, Mahmoud, Karim D, Vermeer, Alexa, Wilde, Arthur, Favalli, Valentina, Guttmann, Oliver P, Gallego-Delgado, Maria, Dominguez, Fernando, Tanini, Ilaria, Kubo, Toru, Keren, Andre, Bueser, Teofila, Waters, Sarah, Issa, Issa F, Malcolmson, James, Burns, Tom, Sekhri, Neha, Hoeger, Christopher W, Omar, Rumana Z, Elliott, Perry M

“…BACKGROUND:Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk of sudden cardiac death (SCD) and require a prophylactic implantable…”
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Predictors of atrial fibrillation in hypertrophic cardiomyopathy by Guttmann, Oliver P, Pavlou, Menelaos, O'Mahony, Constantinos, Monserrat, Lorenzo, Anastasakis, Aristides, Rapezzi, Claudio, Biagini, Elena, Gimeno, Juan Ramon, Limongelli, Giuseppe, Garcia-Pavia, Pablo, McKenna, William J, Omar, Rumana Z, Elliott, Perry M

“…Atrial fibrillation (AF) is associated with increased morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM). The primary aim of this study…”
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A comparison of imputation techniques for handling missing predictor values in a risk model with a binary outcome by Ambler, Gareth, Omar, Rumana Z, Royston, Patrick

“…Risk models that aim to predict the future course and outcome of disease processes are increasingly used in health research, and it is important that they are…”
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