Search Results - "Omar, RA"

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid by Chyan, Yau-Jan, Poeggeler, Burkhard, Omar, Rawhi A., Chain, Daniel G., Frangione, Blas, Ghiso, Jorge, Pappolla, Miguel A.

“…Widespread cerebral deposition of a 40–43-amino acid peptide called the amyloid β-protein (Aβ) in the form of amyloid fibrils is one of the most prominent…”
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Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo by Pappolla, MA, Chyan, YJ, Omar, RA, Hsiao, K, Perry, G, Smith, MA, Bozner, P

“…Increased expression of antioxidant enzymes and heat-shock proteins are key markers of oxidative stress. Such proteins are abnormally present within the…”
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Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide by Pappolla, Miguel A, Sos, Melisa, Omar, Rawhi A, Bick, Roger J, Hickson-Bick, Diane L. M, Reiter, Russel J, Efthimiopoulos, Spiros, Robakis, Nickolaos K

“…Studies from several laboratories have generated evidence suggesting that oxidative stress is involved in the pathogenesis of Alzheimer's disease (AD). The…”
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Immunohistochemical evidence of antioxidant stress in Alzheimer's disease by PAPPOLLA, M. A, OMAR, R. A, KIM, K. S, ROBAKIS, N. K

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Extramedullary plasmacytomas of the head and neck by Wax, M K, Yun, K J, Omar, R A

“…Extramedullary plasmacytomas are solitary tumors consisting of neoplastic plasma cell proliferations that occur in locations other than bone. On initial…”
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Induction of NADPH cytochrome P450 reductase by the Alzheimer β‐protein. Amyloid as a ‘foreign body’ by Pappolla, Miguel A., Omar, Rawhi A., Chyan, Yau‐Jan, Ghiso, Jorge, Hsiao, Karen, Bozner, Peter, Perry, George, Smith, Mark A., Cruz‐Sanchez, Felix

“…A large body of data suggests that the Alzheimer's amyloid peptide (Aβ) causes degeneration and death of neurons by mechanisms that involve reactive oxygen…”
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Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques by Pappolla, MA, Omar, RA, Vinters, HV

“…Amyloid is a component of the senile plaques that characterize one of the major neuropathologic changes in patients with Alzheimer's disease (AD). The sequence…”
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IMMUNOCYTOCHEMICAL EXPRESSION OF THE 70 kD HEAT SHOCK PROTEIN IN ISCHAEMIC BOWEL DISEASE by LU, XIANG-PING, OMAR, RAWHI A., CHANG, WILLIAM W. L.

“…Heat shock proteins (HSPs) are a family of polypeptides which are induced in response to diverse forms of cell injury including hyperthermia, anoxia, ethanol,…”
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Hydrogen peroxide and reoxygenation cause prostaglandin-mediated contraction of human placental arteries and veins by Omar, H A, Figueroa, R, Omar, R A, Tejani, N, Wolin, M S

“…Because our previous studies in several vascular preparations suggest that posthypoxic reoxygenation elicits tone responses by generation of hydrogen peroxide…”
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The genesis of the senile plaque. Further evidence in support of its neuronal origin by Pappolla, MA, Omar, RA, Sambamurti, K, Anderson, JP, Robakis, NK

“…Senile plaques are among the most conspicuous neuropathologic changes found in the brains of elderly individuals and patients with Alzheimer's disease (AD)…”
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The heat shock/oxidative stress connection. Relevance to Alzheimer disease by Pappolla, M A, Sos, M, Omar, R A, Sambamurti, K

“…Involvement of free-radical oxidations in the aging process has been a topic of interest since Harman's original contribution. Because of the close association…”
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Antioxidant enzymes and survival of normal and simian virus 40-transformed mouse embryo cells after hyperthermia by OMAR, R. A, YANO, S, KIKKAWA, Y

“…Relative cell survival and activity of the free radical scavenging enzymes superoxide dismutase, catalase, and glutathione peroxidase were measured in cloned…”
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Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins by Pappolla, M.A., Sambamurti, K., Efthimiopoulos, S., Refolo, L., Omar, R.A., Robakis, N.K.

“…The heat shock or stress response may play a role in the pathogenesis of Alzheimer's disease. We conducted experiments to visualize microscopically the…”
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Properties of an endogenous arachidonic acid--elicited relaxing mechanism in human placental vessels by Omar, H A, Figueroa, R, Omar, R A, Wolin, M S

“…Our objective was to examine the action of arachidonic acid on tone in isolated human placental arteries and veins (1 to 2 mm diameter) for mechanisms…”
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Heat shock protein synthesis and cell survival in clones of normal and simian virus 40-transformed mouse embryo cells by OMAR, R. A, LANKS, K. W

“…Exposure to hyperthermia induces the synthesis of a set of highly conserved polypeptides known as heat shock proteins (HSPs) in cells of most organisms. Since…”
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Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease [published erratum appears in Am J Pathol 1996 Nov;149(5):1770] by Pappolla, MA, Omar, RA, Kim, KS, Robakis, NK

“…Membrane and cytoskeletal structures are known targets of oxidative injury. Brains from patients with Alzheimer's disease have cytoskeletal abnormalities and…”
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Ovarian follicular fluid beta-endorphin levels in normal and polycystic ovaries by Aleem, F A, Eltabbakh, G H, Omar, R A, Southren, A L

“…The possibility of local ovarian production of beta-endorphin prompted us to measure beta-endorphin levels in 19 follicular fluid samples obtained from normal…”
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Immunoreactive beta-endorphin in human ovaries by Aleem, F A, Omar, R A, elTabbakh, G H

“…Beta-endorphin (beta-EP) immunostainable cells were demonstrated in human ovarian tissue using a non-cross-reacting anti-beta-EP serum and the…”
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Immunoreactive beta-endorphin in ovarian sex cord-stromal tumors by Omar, R A, el Tabbakh, G H

“…The possible production of the opioid polypeptide beta-endorphin (beta-EP) was investigated in paraffin-embedded tissue from 17 ovarian tumors with the use of…”
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Origin of phenotypic variation in clones of simian virus 40-transformed mouse embryo cells by Omar, R A, Lanks, K W

“…The present study demonstrates that cloned mouse embryo cell populations, mainly fibroblastic in morphology, differ in biological behavior. Certain of these…”
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