Search Results - "Omar, Nesreen"
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Exploring the role of Müller cells-derived exosomes in diabetic retinopathy
Published in Microvascular research (01-07-2024)“…Exosomes are nanosized vesicles that have been reported as cargo-delivering vehicles between cells. Müller cells play a crucial role in the pathogenesis of…”
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Amelioration of Diabetic Nephropathy by Targeting Autophagy via Rapamycin or Fasting: Relation to Cell Apoptosis/Survival
Published in Current issues in molecular biology (22-10-2021)“…Autophagy has been demonstrated to have a beneficial effect on diabetic nephropathy (DN). Rapamycin, an inhibitor of mTOR, was shown to stimulate β-cell…”
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The impact of busulfan on the testicular structure in prepubertal rats: A histological, ultrastructural and immunohistochemical study
Published in Ultrastructural pathology (03-09-2023)“…Busulfan is a widely used cancer chemotherapeutic agent. Temporary or permanent sterility in male patients is one of the most common side effects of this drug…”
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Comparative study of the ameliorative effects of omega-3 versus selenium on etoposide-induced changes in Sertoli cells and ectoplasmic specialization of adult rat testes: immunohistochemical and electron microscopic study
Published in Journal of molecular histology (01-06-2022)“…Etoposide (Eto) is an anti-cancer drug that is associated with serious adverse effects on male reproductive function. Omega-3 polyunsaturated fatty acids (ω-3…”
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Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2019)“…Histone deacetylase 6 (HDAC6) is an attractive target for cancer therapeutic intervention. Selective HDAC6 inhibitors is important to minimise the side effects…”
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Serum omentin-1 as a predictor of activity in Crohn’s disease
Published in The Egyptian journal of internal medicine (01-10-2019)“…Background and aim Crohn’s disease (CD) is associated with alterations in fat mass and fat distributions, with changed productions of adipokines, including…”
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The outcome of the online virtual classes during COVID-19 pandemic: A study in the female campus of the faculty of medicine in Rabigh-King Abdulaziz University
Published in The journal of microscopy & ultrastructure (01-07-2022)“…Background: COVID-19 pandemic has affected the educational process greatly in the academic year 2019-2020. Therefore, this warranted an urgent and effective…”
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Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds
Published in Molecules (Basel, Switzerland) (31-01-2018)“…A new series of 1-phenyl-3-(4-(pyridin-3-yl)phenyl)urea derivatives were synthesized and subjected to in vitro antiproliferative screening against National…”
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Empagliflozin suppresses hedgehog pathway, alleviates ER stress, and ameliorates hepatic fibrosis in rats
Published in Scientific reports (03-11-2023)“…Worldwide mortality from hepatic fibrosis remains high, due to hepatocellular carcinoma and end stage liver failure. The progressive nature of hepatic fibrosis…”
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Rifaximin Protects against Malathion-Induced Rat Testicular Toxicity: A Possible Clue on Modulating Gut Microbiome and Inhibition of Oxidative Stress by Mitophagy
Published in Molecules (Basel, Switzerland) (24-06-2022)“…Testicular dysfunction is caused by chronic exposure to environmental pollution, such as malathion, which causes oxidative stress, promoting cell damage…”
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Nigella sativa oil alleviates ultrastructural alterations induced by tramadol in rat motor cerebral cortex
Published in The journal of microscopy & ultrastructure (01-04-2016)“…Tramadol is an opioid analgesic used to alleviate acute and chronic pain. Nigella sativa oil is one of the traditional remedies with antioxidant activity. This…”
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Role of nuclear factor-kappa B in bleomycin induced pulmonary fibrosis and the probable alleviating role of ginsenoside: histological, immunohistochemical, and biochemical study
Published in Anatomy & cell biology (31-12-2021)“…Bleomycin (BLM) is one of anti-cancerous drugs. One of its limitation is the development of pulmonary fibrosis during therapy So, we proposed to examine the…”
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A combined administration of GABA agonist and L-histidine synergistically alleviates obesity-induced neuro-lipotoxicity and distorted metabolic transcriptome
Published in Scientific African (01-06-2024)“…Obesity stands as a pervasive and significant global health issue, with a lack of definitive and curative therapeutic solutions currently available. Here we…”
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Nephroprotective Role of Combined Sitagliptin and Oleuropein in Cisplatin-Induced Acute Kidney Injury: Regulation of SDF-1α/Nrf2/ HO-1 Axis and Autophagy
Published in Archives of Pharmaceutical Sciences Ain Shams University (01-12-2021)“…Background: Accumulating evidence proves that cisplatin, a widely used anticancer, causes acute kidney injury (AKI). Sitagliptin (Sita), a dipeptidyl…”
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Platelet-rich plasma-induced feedback inhibition of activin A/follistatin signaling: A mechanism for tumor-low risk skin rejuvenation in irradiated rats
Published in Journal of photochemistry and photobiology. B, Biology (01-03-2018)“…Platelet-rich plasma (PRP) is a source of natural growth factors and is emerging as a treatment modality to mitigate radiotherapy- induced adverse effects…”
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Optimized platelet rich plasma releasate (O-rPRP) repairs galactosemia-induced ovarian follicular loss in rats by activating mTOR signaling and inhibiting apoptosis
Published in Heliyon (01-09-2020)“…Platelet rich plasma contains a collection of growth factors, and an optimal formulation, named O-rPRP, contains the highest possible concentration of growth…”
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Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness
Published in Journal of Egyptian National Cancer Institute (01-06-2017)“…Introduction: Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis. Reduced mitochondrial…”
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Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling
Published in Pharmacology, biochemistry and behavior (01-09-2017)“…Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways. Consequently, the precise…”
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Assessment of oxLDL, anti-oxLDL antibodies and lipoprotein-associated phospholipase A2 as cardiovascular risk markers in obese adolescents with and without T1DM
Published in Bulletin of the Faculty of Pharmacy (01-12-2017)“…Oxidized low density lipoprotein (oxLDL), anti-oxLDL antibodies (oxLDL Ab) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are the sequel of lipoprotein…”
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