Low dose multidetector computed tomography in localizing the transition zone of Hirschsprung’s Disease: A novel study

The objectives of this study were the evaluation of low dose multidetector computed tomography (MDCT) in localizing the site of the transition zone (TZ) of Hirschsprung’s Disease (HD) for preoperative planning. Twenty-two infants were recruited from pediatric and surgical clinics in Assiut Universit...

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Bibliographic Details
Published in:	Egyptian journal of radiology and nuclear medicine Vol. 47; no. 4; pp. 1585 - 1590
Main Authors:	Seifeldein, Gehan S., Omar, Nagham N., Faddan, Nagla H. Abu, Elraheem, Omar Abd
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-12-2016 SpringerOpen
Subjects:	Congenital megacolon Hirschsprung’s disease (HD) Low-dose MDCT Transition zone (TZ) Congenital megacolon Transition zone (TZ) Hirschsprung’s disease (HD) Low-dose MDCT
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Summary:	The objectives of this study were the evaluation of low dose multidetector computed tomography (MDCT) in localizing the site of the transition zone (TZ) of Hirschsprung’s Disease (HD) for preoperative planning. Twenty-two infants were recruited from pediatric and surgical clinics in Assiut University Hospital and Sohag University Hospital. The recruited patients were sedated before examination. Examinations were done using 64-rows MDCT. Each MDCT examination was reviewed to determine the location and length of the TZ and compared with operative and pathological results. Results were analyzed by chi square test and interobserver agreement using Kappa test. P<0.05 was considered statistically significant. According to operative and pathological data, the site of the TZ: 17 (77.27%) were of short-segment disease (rectosigmoid HD), 2 (9%) were of long segment (above sigmoid colon), and 3 (13.63%) were of ultrashort segment. A correct diagnosis of TZ by MDCT was made in 19 out of 22 with 82.4% sensitivity and 80% specificity. The site of TZ was concordant in 17. Results yielded a moderate strength of inter-observer agreement in localizing the site of TZ (k=0.546) and (P=0.009). Low-dose MDCT has a good role in localizing the site of TZ of HD in infants.
ISSN:	0378-603X
DOI:	10.1016/j.ejrnm.2016.06.019