Search Results - "Omar, Hany A."

BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease by Moussa‐Pacha, Nour M., Abdin, Shifaa M., Omar, Hany A., Alniss, Hasan, Al‐Tel, Taleb H.

“…Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of the important therapeutic approaches of…”
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Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions by Arab, Hany H, Salama, Samir A, Omar, Hany A, Arafa, El-Shaimaa A, Maghrabi, Ibrahim A

“…Alcohol consumption has been commonly associated with gastric mucosal lesions including gastric ulcer. Diosmin (DIO) is a natural citrus flavone with…”
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Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis by Omar, Hany A, Mohamed, Wafaa R, Arab, Hany H, Arafa, El-Shaimaa A

“…Despite its broad applications, cisplatin affords considerable nephro- and hepatotoxicity through triggering inflammatory and oxidative stress cascades. The…”
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Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance by Elgendy, Sara M., Alyammahi, Shatha K., Alhamad, Dima W., Abdin, Shifaa M., Omar, Hany A.

“…•Cancer stem cells play a crucial role in cancer drug resistance and tumor relapse.•Complete tumor eradication could be achieved by targeting cancer stem…”
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Immunotherapy, an evolving approach for the management of triple negative breast cancer: Converting non-responders to responders by Tolba, Mai F., Omar, Hany A.

“…•Immunotherapy is an evolving approach for TNBC.•Co-treatment with nab-paclitaxel, CDK4/6 inhibitors or tyrosine kinase inhibitors.•Targeting Tim-3/CTLA-4…”
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The dynamic association between COVID-19 and chronic disorders: An updated insight into prevalence, mechanisms and therapeutic modalities by Alyammahi, Shatha K., Abdin, Shifaa M., Alhamad, Dima W., Elgendy, Sara M., Altell, Amani T., Omar, Hany A.

“…The devastating pandemic of coronavirus disease 2019 (COVID-19) has caused thousands of deaths and left millions of restless patients suffering from its…”
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Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents by Abdelgawad, Mohamed A., Bakr, Rania B., Omar, Hany A.

“…[Display omitted] •A series of substituted pyrazoles10a-c, 11a-c and 12a- was designed and prepared.•All the candidates…”
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Tackling molecular targets beyond PD-1/PD-L1: Novel approaches to boost patients’ response to cancer immunotherapy by Omar, Hany A., Tolba, Mai F.

“…In the new era of immunotherapy, which has changed the clinical oncology practice guidelines, there is a pressing need for finding novel approaches to tune up…”
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Bee Pollen: Current Status and Therapeutic Potential by Khalifa, Shaden A. M, Elashal, Mohamed H, Yosri, Nermeen, Du, Ming, Musharraf, Syed G, Nahar, Lutfun, Sarker, Satyajit D, Guo, Zhiming, Cao, Wei, Zou, Xiaobo, Abd El-Wahed, Aida A, Xiao, Jianbo, Omar, Hany A, Hegazy, Mohamed-Elamir F, El-Seedi, Hesham R

“…Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public…”
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Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways by Azouz, Amany A., Omar, Hany A., Hersi, Fatema, Ali, Fares E.M., Hussein Elkelawy, Asmaa Mohammed M.

“…The calcineurin inhibitor tacrolimus is an effective and widely used immunosuppressant after organ transplantation to reduce graft rejection. However, its…”
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Comparative sphingolipidomic analysis reveals significant differences between doxorubicin-sensitive and -resistance MCF-7 cells by Shammout, Ola D. A, Ashmawy, Naglaa S, Shakartalla, Sarra B, Altaie, Alaa M, Semreen, Mohammad H, Omar, Hany A, Soliman, Sameh S. M

“…Drug resistance is responsible for the failure of many available anticancer drugs. Several studies have demonstrated the association between the alteration in…”
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Camel Milk Attenuates Rheumatoid Arthritis Via Inhibition of Mitogen Activated Protein Kinase Pathway by Arab, Hany H., Salama, Samir A., Abdelghany, Tamer M., Omar, Hany A., Arafa, El-Shaimaa A., Alrobaian, Majed M., Maghrabi, Ibrahim A.

“…Background/Aims: Camel milk (CM) has shown beneficial anti-inflammatory actions in several experimental and clinical settings. So far, its effect on rheumatoid…”
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Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites by Soliman, Sameh S M, Alhamidi, Tasneem B, Abdin, Shifaa, Almehdi, Ahmed M, Semreen, Mohammad H, Alhumaidi, Razan B, Shakartalla, Sarra B, Haider, Mohamed, Husseiny, Mohamed I, Omar, Hany A

“…Biogenic synthesis of nanoparticles provides many advantages over synthetic nanoparticles including clean and non-toxic approaches. Nanoparticle-based…”
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PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells by Bajbouj, Khuloud, Ramakrishnan, Rakhee K., Saber-Ayad, Maha, Omar, Hany A., Saheb Sharif-Askari, Narjes, Shafarin, Jasmin, Elmoselhi, Adel B., Ihmaid, Ahmed, AlHaj Ali, Suhib, Alalool, Abdulla, Abdullah, Reem, Hamid, Qutayba

“…As a therapeutic approach, epigenetic modifiers have the potential to enhance the efficacy of chemotherapeutic agents. Protein arginine methyltransferase 5…”
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Antibacterial Activity of Small Molecules Which Eradicate Methicillin-Resistant Staphylococcus aureus Persisters by Hamad, Mohamad, Al-Marzooq, Farah, Srinivasulu, Vunnam, Omar, Hany A, Sulaiman, Ashna, Zaher, Dana M, Orive, Gorka, Al-Tel, Taleb H

“…The serious challenge posed by multidrug-resistant bacterial infections with concomitant treatment failure and high mortality rates presents an urgent threat…”
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L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38/c-Fos signaling, and the proinflammatory cytokines by Salama, Samir A., Arab, Hany H., Omar, Hany A., Gad, Hesham S., Abd-Allah, Gamil M., Maghrabi, Ibrahim A., Al robaian, Majed M.

“…UVA comprises more than 90% of the solar UV radiation reaching the Earth. Artificial lightening lamps have also been reported to emit significant amounts of…”
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New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study by Fadaly, Wael A A, Nemr, Mohamed T M, Zidan, Taha H, Mohamed, Fatma E A, Abdelhakeem, Marwa M, Abu Jayab, Nour N, Omar, Hany A, Abdellatif, Khaled R A

“…A new series of bis-triazole 19a-l was synthesised for the purpose of being hybrid molecules with both anti-inflammatory and anti-cancer activities and…”
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The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers by Tolba, Mai F., Omar, Hany A., Hersi, Fatima, Nunes, Ane C.F., Noreddin, Ayman M.

“…Estrogen (E2) plays a central role in the development and progression of hormone-responsive cancers. Estrogen metabolites exhibit either stimulatory or…”
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Multi-Omics Analysis Revealed a Significant Alteration of Critical Metabolic Pathways Due to Sorafenib-Resistance in Hep3B Cell Lines by Abushawish, Kholoud Y. I., Soliman, Sameh S. M., Giddey, Alexander D., Al-Hroub, Hamza M., Mousa, Muath, Alzoubi, Karem H., El-Huneidi, Waseem, Abu-Gharbieh, Eman, Omar, Hany A., Elgendy, Sara M., Bustanji, Yasser, Soares, Nelson C., Semreen, Mohammad H.

“…Hepatocellular carcinoma (HCC) is the second prominent cause of cancer-associated death worldwide. Usually, HCC is diagnosed in advanced stages, wherein…”
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OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53 by Omar, Hany A, Tolba, Mai F, Hung, Jui-Hsiang, Al-Tel, Taleb H

“…Sorafenib (Nexavar ) is an FDA-approved systemic therapy for advanced hepatocellular carcinoma (HCC). However, the low efficacy and adverse effects at high…”
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