Associations between echocardiographic findings and prospective changes in residual renal function in patients new to peritoneal dialysis

Although echocardiograms are often performed when peritoneal dialysis is started, associations between commonly reported findings and prospective changes in renal function remain understudied. Ninety-nine of 101 patients in the Trio Trial had transthoracic echocardiograms within 6 months of dialysis...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; pp. 18434 - 7
Main Authors:	Mahdavi, Sara, Yared, Kibar, Wu, George, Omar, Billy, Savundra, Dinesh, Nagai, Gordon, Hockmann, Edgar, Svendrovski, Anton, Bellasi, Antonio, Tam, Paul, Sikaneta, Tabo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05-12-2019 Nature Publishing Group
Subjects:	692/4022/1585/104/1586 692/4022/1950/1724 Aged Blood pressure Calcification Creatinine - blood Creatinine - metabolism Dialysis Disease Progression Echocardiography Female Follow-Up Studies Glomerular Filtration Rate - physiology Heart Humanities and Social Sciences Humans Hypertrophy Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - diagnosis Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - physiopathology Kidney - physiopathology Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Linear Models Male Middle Aged Models, Biological multidisciplinary Peritoneal Dialysis Peritoneum Prospective Studies Renal Dialysis Renal Elimination - physiology Renal function Science Science (multidisciplinary) Stroke Volume - physiology Ultrasonic imaging Urea - blood Urea - metabolism Ventricle Ventricular Function, Left - physiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Although echocardiograms are often performed when peritoneal dialysis is started, associations between commonly reported findings and prospective changes in renal function remain understudied. Ninety-nine of 101 patients in the Trio Trial had transthoracic echocardiograms within 6 months of dialysis initiation, and measurements of residual renal function every six weeks for up to two years. Generalized mixed modelling linear regression in STATA was used to examine associations between left atrial size, left ventricular hypertrophy, left ventricular ejection fraction, right ventricular systolic pressure, and left valvular calcification with subsequent slopes in renal function. After echocardiography (performed a median of 16 days following peritoneal dialysis initiation) right ventricular systolic pressure was associated with faster , while declining left ventricular ejection fraction and valvular calcification were associated with slower declines in residual renal function. Future studies could be conducted to confirm these findings, and identify pathophysiological mechanisms.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-54851-2