Search Results - "Oman, Trent J."

Follow the leader: the use of leader peptides to guide natural product biosynthesis by van der Donk, Wilfred A, Oman, Trent J

“…The avalanche of genomic information in the past decade has revealed that natural product biosynthesis using the ribosomal machinery is much more widespread…”
Get full text

Mode of action and structure–activity relationship studies of geobacillin I by Garg, Neha, Oman, Trent J, Andrew Wang, Tsung-Shing, De Gonzalo, Chantal V Garcia, Walker, Suzanne, van der Donk, Wilfred A

Get full text

Sublancin is not a lantibiotic but an S-linked glycopeptide by van der Donk, Wilfred A, Oman, Trent J, Boettcher, John M, Wang, Huan, Okalibe, Xenia N

“…Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a cysteine residue, establishing a new post-translational modification. The…”
Get full text

Enantiomeric purity analysis of synthetic peptide therapeutics by direct chiral high-performance liquid chromatography-electrospray ionization tandem mass spectrometry by Strege, Mark A., Oman, Trent J., Risley, Donald S., Muehlbauer, Laura K., Jalan, Ankur, Jerry Lian, Zhirui

“…•Chiral separations of underivatized amino acids using Crownpak®CR-I(+) and Chiralpak® ZWIX(-) packings interfaced with HPLC-MS/MS.•Application for purity…”
Get full text

Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin by Oman, Trent J, van der Donk, Wilfred A

“…Haloduracin, a recently discovered two-peptide lantibiotic composed of the post-translationally modified peptides Halα and Halβ, is shown to have high potency…”
Get full text

The Glycosyltransferase Involved in Thurandacin Biosynthesis Catalyzes Both O- and S‑Glycosylation by Wang, Huan, Oman, Trent J, Zhang, Ran, Garcia De Gonzalo, Chantal V, Zhang, Qi, van der Donk, Wilfred A

“…The S-glycosyltransferase SunS is a recently discovered enzyme that selectively catalyzes the conjugation of carbohydrates to the cysteine thiol of proteins…”
Get full text

An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate by Oman, Trent J, Knerr, Patrick J, Bindman, Noah A, Velásquez, Juan E, van der Donk, Wilfred A

“…Ribosomally synthesized and post-translationally modified peptides are a rapidly expanding class of natural products. They are typically biosynthesized by…”
Get full text

Development and Validation of a Multiplexed Protein Quantitation Assay for the Determination of Three Recombinant Proteins in Soybean Tissues by Liquid Chromatography with Tandem Mass Spectrometry by Hill, Ryan C, Oman, Trent J, Shan, Guomin, Schafer, Barry, Eble, Julie, Chen, Cynthia

“…Currently, traditional immunochemistry technologies such as enzyme-linked immunosorbent assays (ELISA) are the predominant analytical tool used to measure…”
Get full text

In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids by Levengood, Matthew R, Knerr, Patrick J, Oman, Trent J, van der Donk, Wilfred A

“…Lantibiotics are ribosomally synthesized and post-translationally modified peptide antibiotics containing the characteristic thioether cross-links lanthionine…”
Get full text

Development, Validation, and Interlaboratory Evaluation of a Quantitative Multiplexing Method To Assess Levels of Ten Endogenous Allergens in Soybean Seed and Its Application to Field Trials Spanning Three Growing Seasons by Hill, Ryan C, Oman, Trent J, Wang, Xiujuan, Shan, Guomin, Schafer, Barry, Herman, Rod A, Tobias, Rowel, Shippar, Jeff, Malayappan, Bhaskar, Sheng, Li, Xu, Austin, Bradshaw, Jason

“…As part of the regulatory approval process in Europe, comparison of endogenous soybean allergen levels between genetically engineered (GE) and non-GE plants…”
Get full text

Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry by Oman, Trent J, Lupoli, Tania J, Wang, Tsung-Shing Andrew, Kahne, Daniel, Walker, Suzanne, van der Donk, Wilfred A

“…The two-peptide lantibiotic haloduracin is composed of two post-translationally modified polycyclic peptides that synergistically act on Gram-positive…”
Get full text

NMR Structure of the S‑Linked Glycopeptide Sublancin 168 by Garcia De Gonzalo, Chantal V, Zhu, Lingyang, Oman, Trent J, van der Donk, Wilfred A

“…Sublancin 168 is a member of a small group of glycosylated antimicrobial peptides known as glycocins. The solution structure of sublancin 168, a 37-amino-acid…”
Get full text

Non-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation by Knerr, Patrick J, Oman, Trent J, Garcia De Gonzalo, Chantal V, Lupoli, Tania J, Walker, Suzanne, van der Donk, Wilfred A

“…Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain the thioether structures lanthionine and…”
Get full text

Characterization of Aryloxyalkanoate Dioxygenase-12, a Nonheme Fe(II)/α-Ketoglutarate-Dependent Dioxygenase, Expressed in Transgenic Soybean and Pseudomonas fluorescens by Griffin, Samantha L, Godbey, Jeffrie A, Oman, Trent J, Embrey, Shawna K, Karnoup, Anton, Kuppannan, Krishna, Barnett, Brian W, Lin, Gaofeng, Harpham, Nicholas V. J, Juba, Amber N, Schafer, Barry W, Cicchillo, Robert M

“…Aryloxyalkanoate dioxygenase-12 (AAD-12) was discovered from the soil bacterium Delftia acidovorans MC1 and is a nonheme Fe(II)/α-ketoglutarate-dependent…”
Get full text

Evaluation of an HPLC Chiral Separation Flow Scheme for Small Molecules by Sharp, V. Scott, Risley, Donald S., Oman, Trent J., Starkey, Lauren E.

“…An HPLC chiral separation flow scheme was developed for identification of suitable enantioseparation conditions for small molecules. This flow scheme employs…”
Get full text

Biosynthesis and mode of action of ribosomally synthesized and post-translationally modified antimicrobial peptides by Oman, Trent J

“…One of the greatest sources of biologically active compounds is natural products. Often these compounds serve as platforms for the design and development of…”
Get full text