Search Results - "Omabe, Kenneth"

Deeper Insight in Metastatic Cancer Progression; Epithelial-to- Mesenchymal Transition and Genomic Instability: Implications on Treatment Resistance by Omabe, Kenneth, Uduituma, Sandra, Igwe, David, Omabe, Maxwell

“…Therapy resistance remains the major obstacle to successful cancer treatment. Epithelial-to- mesenchymal transition [EMT], a cellular reprogramming process…”
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DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation by Xu, Xiaohua, Chang, Chou-Wei, Li, Min, Omabe, Kenneth, Le, Nhung, Chen, Yi-Hsuan, Liang, Feng, Liu, Yilun

“…Deletion of the conserved C-terminus of the Rothmund-Thomson syndrome helicase RECQ4 is highly tumorigenic. However, while the RECQ4 N-terminus is known to…”
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Emerging Metabolomics Biomarkers of Polycystic Ovarian Syndrome; Targeting the Master Metabolic Disrupters for Diagnosis and Treatment by Omabe, Maxwell, Elom, Sunday, Omabe, Kenneth N

“…Metabolomics is a powerful exploratory tool for discovering new diagnostic molecules or biomarkers due to its ability to highlight several interactions between…”
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Understanding the Human RECQ5 Helicase—Connecting the Dots from DNA to Clinics by Mo, Chiefe, Shiozaki, Yukari, Omabe, Kenneth, Liu, Yilun

“…RECQ5, a member of the conserved RECQ helicase family, is the sole human RECQ homolog that has not been linked to a hereditary developmental syndrome…”
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Nanovectorization of Prostate Cancer Treatment Strategies: A New Approach to Improved Outcomes by Omabe, Kenneth, Paris, Clément, Lannes, François, Taïeb, David, Rocchi, Palma

“…Prostate cancer (PC) is the most frequent male cancer in the Western world. Progression to Castration Resistant Prostate Cancer (CRPC) is a known consequence…”
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ZNF703 mRNA-Targeting Antisense Oligonucleotide Blocks Cell Proliferation and Induces Apoptosis in Breast Cancer Cell Lines by Udu-Ituma, Sandra, Adélaïde, José, Le, Thi Khanh, Omabe, Kenneth, Finetti, Pascal, Paris, Clément, Guille, Arnaud, Bertucci, François, Birnbaum, Daniel, Rocchi, Palma, Chaffanet, Max

“…The luminal B molecular subtype of breast cancers (BC) accounts for more than a third of BCs and is associated with aggressive clinical behavior and poor…”
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Metabolic Basis of Polycystic Ovarian Syndrome; Indications for Biochemical Screening by Omabe, Maxwell, Omabe, Kenneth Nwobini, Clement, Famurewa Ademola, Omabe, Grace Maxwell

“…Polycystic ovary syndrome (PCOS) is a heterogeneous condition with wide range of phenotype the cause of this disorder is unknown, however, increased ovarian…”
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Anion Gap Toxicity in Alloxan Induced Type 2 Diabetic Rats Treated with Antidiabetic Noncytotoxic Bioactive Compounds of Ethanolic Extract of Moringa oleifera by Okorocha, Albert Egwu, Omabe, Kenneth Nwobini, Nwudele, Chibueze, Omabe, Maxwell

“…Moringa oleifera (MO) is used for a number of therapeutic purposes. This raises the question of safety and possible toxicity. The objective of the study was to…”
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The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops by Chang, Chou-Wei, Singh, Anup Kumar, Li, Min, Guan, Li, Le, Nhung, Omabe, Kenneth, Liang, Feng, Liu, Yilun

“…R-loops, or RNA:DNA hybrids, can induce DNA damage, which requires DNA repair factors including breast cancer type 1 susceptibility protein (BRCA1) to restore…”
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DDX5 mRNA-targeting antisense oligonucleotide as a new promising therapeutic in combating castration-resistant prostate cancer by Le, Thi Khanh, Cherif, Chaïma, Omabe, Kenneth, Paris, Clément, Lannes, François, Audebert, Stéphane, Baudelet, Emilie, Hamimed, Mourad, Barbolosi, Dominique, Finetti, Pascal, Bastide, Cyrille, Fazli, Ladan, Gleave, Martin, Bertucci, François, Taïeb, David, Rocchi, Palma

“…The heat shock protein 27 (Hsp27) has emerged as a principal factor of the castration-resistant prostate cancer (CRPC) progression. Also, an antisense…”
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IZNF703/I mRNA-Targeting Antisense Oligonucleotide Blocks Cell Proliferation and Induces Apoptosis in Breast Cancer Cell Lines by Udu-Ituma, Sandra, Adélaïde, José, Le, Thi Khanh, Omabe, Kenneth, Finetti, Pascal, Paris, Clément, Guille, Arnaud, Bertucci, François, Birnbaum, Daniel, Rocchi, Palma, Chaffanet, Max

“…The luminal B molecular subtype of breast cancers (BC) accounts for more than a third of BCs and is associated with aggressive clinical behavior and poor…”
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Exposure of Prostate to Lipopolysaccharide and Hypoxia Potentiates Neoplastic Behavior and Risk for Prostate Carcinogenesis In Vivo by Omabe, Maxwell, Omabe, Kenneth, Okwuegbu, Martin, Grace, Ogo, Okoro, Desmond Uchenna

“…A number of studies showed that men from tropical countries have higher burden of prostate cancer similar to data from USA. We developed a translational model…”
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