Search Results - "Olzinski, Alan R"

Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat by Bao, Weike, Qin, Pu, Needle, Saul, Erickson-Miller, Connie L, Duffy, Kevin J, Ariazi, Jennifer L, Zhao, Shufang, Olzinski, Alan R, Behm, David J, Teg Pipes, G C, Jucker, Beat M, Hu, Erding, Lepore, John J, Willette, Robert N

“…BACKGROUND:Hypoxia inducible factors (HIFs) are transcription factors that are regulated by HIF-prolyl 4-hydroxylases (PHDs) in response to changes in oxygen…”
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Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease by Willette, Robert N, Eybye, Marianne E, Olzinski, Alan R, Behm, David J, Aiyar, Nambi, Maniscalco, Kristeen, Bentley, Ross G, Coatney, Robert W, Zhao, Shufang, Westfall, Timothy D, Doe, Chris P

“…The evidence is compelling for a role of inflammation in cardiovascular diseases; however, the chronic use of anti-inflammatory drugs for these indications has…”
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Differential uptake of ferumoxtran-10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: Critical determinants of atherosclerotic plaque labeling by Yancy, April D., Olzinski, Alan R., Hu, Tom C-C., Lenhard, Stephen C., Aravindhan, Karpagam, Gruver, Susan M., Jacobs, Paula M., Willette, Robert N., Jucker, Beat M.

“…Purpose To compare atherosclerotic plaque uptake of a first (ferumoxtran‐10) and second generation (ferumoxytol) ultrasmall superparamagnetic iron oxide…”
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Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress by Costell, Melissa H, Ancellin, Nicolas, Bernard, Roberta E, Zhao, Shufang, Upson, John J, Morgan, Lisa A, Maniscalco, Kristeen, Olzinski, Alan R, Ballard, Victoria L T, Herry, Kenny, Grondin, Pascal, Dodic, Nerina, Mirguet, Olivier, Bouillot, Anne, Gellibert, Francoise, Coatney, Robert W, Lepore, John J, Jucker, Beat M, Jolivette, Larry J, Willette, Robert N, Schnackenberg, Christine G, Behm, David J

“…Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms…”
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In vivo serial assessment of aortic aneurysm formation in apolipoprotein E-deficient mice via MRI by Turner, Gregory H, Olzinski, Alan R, Bernard, Roberta E, Aravindhan, Karpagam, Karr, Heather W, Mirabile, Rosanna C, Willette, Robert N, Gough, Peter J, Jucker, Beat M

“…Hyperlipidimic mice administered angiotensin II have been used for the study of abdominal aortic aneurysms (AAAs). The purpose of this study was to examine the…”
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p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension by Ju, Haisong, Behm, David J, Nerurkar, Sandyha, Eybye, Marianne E, Haimbach, Robin E, Olzinski, Alan R, Douglas, Stephen A, Willette, Robert N

“…Numerous mediators, believed to play a role in endothelial dysfunction (e.g., neurohormones, cytokines, hypoxia, and stretch), have been shown to activate p38…”
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Development of an LC–MS/MS assay for quantification of intact INSL3 in rat plasma by Schneck, Nicole A, Mortezavi, Lela, Olzinski, Alan R, Posavec, Diane, Jolivette, Larry J, Sikorski, Timothy W, Zhang, Shan-Shan, Schnackenberg, Christine G, Licea-Perez, Hermes

“…Relatively large disulfide-linked polypeptides can serve as signaling molecules for a diverse array of biological processes and may be studied in animal models…”
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Sustained activation of p38 mitogen-activated protein kinase contributes to the vascular response to injury by Ju, Haisong, Nerurkar, Sandhya, Sauermelch, Charles F, Olzinski, Alan R, Mirabile, Rosanna, Zimmerman, Dawn, Lee, John C, Adams, Jerry, Sisko, Joseph, Berova, Marinella, Willette, Robert N

“…The vascular response to mechanical injury involves inflammatory and fibroproliferative processes that result in the formation of neointima and vascular…”
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p38 MAPK Inhibition Reduces Aortic Ultrasmall Superparamagnetic Iron Oxide Uptake in a Mouse Model of Atherosclerosis: MRI Assessment by Morris, Joanne B, Olzinski, Alan R, Bernard, Roberta E, Aravindhan, Karpagam, Mirabile, Rosanna C, Boyce, Rogely, Willette, Robert N, Jucker, Beat M

“…OBJECTIVE—Ultrasmall superparamagnetic iron oxide (USPIO) contrast agents have been used for noninvasive MRI assessment of atherosclerotic plaque inflammation…”
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Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress by Qin, Pu, Arabacilar, Pelin, Bernard, Roberta E, Bao, Weike, Olzinski, Alan R, Guo, Yuanjun, Lal, Hind, Eisennagel, Stephen H, Platchek, Michael C, Xie, Wensheng, Del Rosario, Julius, Nayal, Mohamad, Lu, Quinn, Roethke, Theresa, Schnackenberg, Christine G, Wright, Fe, Quaile, Michael P, Halsey, Wendy S, Hughes, Ashley M, Sathe, Ganesh M, Livi, George P, Kirkpatrick, Robert B, Qu, Xiaoyan A, Rajpal, Deepak K, Faelth Savitski, Maria, Bantscheff, Marcus, Joberty, Gerard, Bergamini, Giovanna, Force, Thomas L, Gatto, Jr, Gregory J, Hu, Erding, Willette, Robert N

“…The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control…”
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Pharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E−/− Mouse: Magnetic Resonance Imaging Assessment by Olzinski, Alan R, Turner, Gregory H, Bernard, Roberta E, Karr, Heather, Cornejo, Carla A, Aravindhan, Karpagam, Hoang, Bao, Ringenberg, Michael A, Qin, Pu, Goodman, Krista B, Willette, Robert N, Macphee, Colin H, Jucker, Beat M, Sehon, Clark A, Gough, Peter J

“…PURPOSE—This study assessed the pharmacological effect of a novel selective C-C chemokine receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage…”
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Assessment of macrophage infiltration in a Murine model of abdominal aortic aneurysm by Turner, Gregory H., Olzinski, Alan R., Bernard, Roberta E., Aravindhan, Karpagam, Boyle, Ryan J., Newman, Matt J., Gardner, Scott D., Willette, Robert N., Gough, Peter J., Jucker, Beat M.

“…Purpose To evaluate the use of an ultrasmall superparamagnetic iron oxide (USPIO) contrast agent as a marker for the detection of macrophage in a preclinical…”
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Soluble Epoxide Hydrolase Inhibition Does Not Prevent Cardiac Remodeling and Dysfunction After Aortic Constriction in Rats and Mice by Morgan, Lisa A, Olzinski, Alan R, Upson, John J, Zhao, Shufang, Wang, Tao, Eisennagel, Stephen H, Hoang, Bao, Tunstead, James R, Marino, Joseph P, Willette, Robert N, Jucker, Beat M, Behm, David J

“…Epoxyeicosatrienoic acids, substrates for soluble epoxide hydrolase (sEH), exhibit vasodilatory and antihypertrophic activities. Inhibitors of sEH might…”
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Patterns of USPIO Deposition in Murine Atherosclerosis by Morris, Joanne B, Olzinski, Alan R, Jucker, Beat M

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PPARδ Activation Normalizes Cardiac Substrate Metabolism and Reduces Right Ventricular Hypertrophy in Congestive Heart Failure by Jucker, Beat M, Doe, Christopher P, Schnackenberg, Christine G, Olzinski, Alan R, Maniscalco, Kristeen, Williams, Carolyn, Hu, Tom C-C, Lenhard, Stephen C, Costell, Melissa, Bernard, Roberta, Sarov-Blat, Lea, Steplewski, Klaudia, Willette, Robert N

“…Previously, it was shown that selective deletion of peroxisome proliferator activated receptor δ (PPARδ) in the heart resulted in a cardiac lipotoxicity,…”
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Hypertensive target organ damage is attenuated by a p38 MAPK inhibitor: role of systemic blood pressure and endothelial protection by Olzinski, Alan R, McCafferty, Tara A, Zhao, Shufang Q, Behm, David J, Eybye, Marianne E, Maniscalco, Kristeen, Bentley, Ross, Frazier, Kendall S, Milliner, Chavon M, Mirabile, Rosanna C, Coatney, Robert W, Willette, Robert N

“…Evidence suggests important relationships among chronic inflammatory processes, endothelial dysfunction, hypertension and target organ damage. The present…”
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Cathepsin S expression is up-regulated following balloon angioplasty in the hypercholesterolemic rabbit by BURNS-KURTIS, Cynthia L, OLZINSKI, Alan R, NEEDLE, Saul, FOX, Josephine H, CAPPER, Elizabeth A, KELLY, Fiona M, MCQUENEY, Michael S, ROMANIC, Anne M

“…Neointimal development following balloon angioplasty involves many factors including smooth muscle cell (SMC) migration and proliferation and extracellular…”
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Enrasentan Improves Survival, Limits Left Ventricular Remodeling, and Preserves Myocardial Performance in Hypertensive Cardiac Hypertrophy and Dysfunction by Willette, Robert N, Anderson, Karen M, Nelson, Allen H, Olzinski, Alan R, Woods, Tina, Coatney, Robert W, Aiyar, Nambi, Ohlstein, Eliot H, Barone, Frank C

“…Evidence suggests that endothelin receptor antagonists may have therapeutic potential for the chronic treatment of heart failure. In the current study, the…”
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Left ventricular adaptation to exercise regulates MAPKs and biomarkers of inflammation and fibrosis by Olzinski, Alan R, Lenhard, Stephen C, Chendrimada, Thimmaiah P, Upson, John J, Hurle, Mark R, Needle, Saul, Willette, Robert N, Jucker, Beat M

“…Exercise regimens are beneficial in normal and failing hearts; however the underlying adaptive mechanisms are not well understood. The purpose of this study…”
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Activation of nitric oxide (NO)‐insensitive soluble guanylate cyclase does not provide greater benefit than NO‐sensitive stimulation in acute and chronic models of cardiovascular disease associated with oxidative stress by Costell, Melissa H., Bernard, Roberta E., Alsaid, Hasan, Upson, John J., Olzinski, Alan R., Morgan, Lisa A., Grondin, Pascal O., Ancellin, Nicolas, Dodic, Nerina, Gellibert, Francoise, Jucker, Beat M., Jolivette, Larry J., Willette, Robert N., Schnackenberg, Christine G., Behm, David J.

“…Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO), exists as reduced (NO‐sensitive) and oxidized (NO‐insensitive) forms. Because…”
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