Search Results - "Olvera, Felipe"
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Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
Published in Nature communications (13-08-2019)“…Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly…”
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Recombinant expression and antigenicity of two peptide families of neurotoxins from Androctonus sp
Published in The journal of venomous animals and toxins including tropical diseases (2022)“…Scorpion neurotoxins such as those that modify the mammalian voltage-gated sodium ion channels (Nav) are the main responsible for scorpion envenomation. Their…”
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Neutralization of black widow spider (Latrodectus mactans) venom with rabbit polyclonal serum hyperimmunized with recombinant alpha-latrotoxin fragments
Published in Biochimie (01-10-2022)“…Alpha-latrotoxin (ɑLTx) is the component responsible for causing the pathophysiology in patients bitten by spiders from the genus Latrodectus, commonly known…”
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Venom of the neotropical rattlesnake, Crotalus culminatus: Intraspecific variation, neutralization by antivenoms, and immunogenicity in rabbits
Published in Biochimie (01-01-2024)“…Crotalus culminatus is a medically significant species of rattlesnake in Mexico [1]. While the proteomic composition of its venom has been previously reported…”
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Neutralization of crotamine by polyclonal antibodies generated against two whole rattlesnake venoms and a novel recombinant fusion protein
Published in Toxicon (Oxford) (15-07-2021)“…Crotamine is a paralyzing toxin (MW: ~5 kDa) found in different proportions in some rattlesnake venoms (up to 62%). Mexican pit viper antivenoms have shown low…”
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Characterization of the venom and external morphology of a natural hybrid between Crotalus atrox and Crotalus mictlantecuhtli
Published in Toxicon (Oxford) (01-02-2022)“…Here we report, for the first time, a natural hybrid between Crotalus atrox and C. mictlantecuhtli based on intermediate characteristics of the external…”
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Assessment of neutralization of Micrurus venoms with a blend of anti-Micrurus tener and anti-ScNtx antibodies
Published in Vaccine (05-02-2021)“…Micrurus venoms contain two main groups of toxic protein components: short-chain α-neurotoxins (SNtx) and phospholipases type A2 (PLA2). In North America,…”
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Use of irradiated elapid and viperid venoms for antivenom production in small and large animals
Published in Toxicon (Oxford) (01-12-2018)“…This work evaluated the feasibility of using toxoids obtained by gamma radiation in the production of antivenoms in small and large animals. Mixtures of…”
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Bone Microenvironment‐Suppressed T Cells Increase Osteoclast Formation and Osteolytic Bone Metastases in Mice
Published in Journal of bone and mineral research (01-08-2022)“…ABSTRACT Immunotherapies use components of the immune system, such as T cells, to fight cancer cells, and are changing cancer treatment, causing durable…”
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Abstract 5281: 5-Fluorouracil decreases MDSC and the development of osteolytic bone metastases from breast cancer in mice
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Bone metastases are a highly debilitating complication in more than 70% of patients with advanced breast and prostate cancer. Currently approved treatments…”
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Production of anti-horse antibodies induced by IgG, F(ab')2 and Fab applied repeatedly to rabbits. Effect on antivenom pharmacokinetics
Published in Toxicon (Oxford) (15-12-2013)“…We separated whole IgG, Fab and F(ab')2 fragments from horse plasma. We previously studied the pharmacokinetics of these immunoglobulins and fragments in…”
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An efficient approach to clone and express active Neopladine 2, an anticancer peptide from Tityus discrepans scorpion venom
Published in Process biochemistry (1991) (01-05-2016)“…[Display omitted] •A new approach to clone active Neo2, a peptide with anticancer properties.•The best conditions to achieve active Neo2 expression in E coli…”
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T cell suppression by the bone microenvironment increases bone metastases from breast cancer in mice
Published in The Journal of immunology (1950) (01-05-2019)“…Bone metastases are a frequent complication of breast cancer and cannot be cured. Immunotherapy could be used for their treatment. However, its efficiency…”
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Bone microenvironment-suppressed T cells increase osteoclast formation and breast cancer bone metastases
Published in The Journal of immunology (1950) (01-05-2020)“…Bone metastases is a frequent (>75%) complication of advanced breast cancer (BCa). BCa cells in bone are supported by cytokines released during the…”
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Abstract 2651: Characterization of TIE2 function in cancer cell dormancy and bone metastases
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…After arriving in bone, cancer cells can enter a dormancy state that can last for years, during which they are resistant to treatment. The bone…”
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Abstract 6199: Bone microenvironment-suppressed T cells increase osteoclast formation and breast cancer bone metastases
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Bone metastases are a frequent complication in patients with advanced breast cancer and remain incurable. Thus, we need to explore new options for their…”
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TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases
Published in Cancers (03-04-2020)“…Breast cancer (BCa) cells disseminating to the bone can remain dormant and resistant to treatments for many years until relapsing as bone metastases. The…”
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Molecular Genetics of the Secretory Pathway in Entamoeba histolytica
Published in Archives of medical research (01-07-2000)Get full text
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