Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats

This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and...

Full description

Saved in:

Bibliographic Details
Published in:	Revista brasileira de farmacognosia Vol. 22; no. 3; pp. 663 - 668
Main Authors:	Mariz, Saulo R., Cerqueira, Gilberto S., Araújo, Washington C., Dantas, Jadson G., Ramalho, Josué A., Palomaro, Thayse V., Duarte, José C., Santos, Hosana B. dos, Olveira, Kardilândia, Araújo, Maria Salete T. de, Diniz, Margareth de F. F. M., Medeiros, Isac A. de
Format:	Journal Article
Language:	English
Published:	Sociedade Brasileira de Farmacognosia 01-06-2012
Subjects:	PHARMACOLOGY & PHARMACY Jatropha gossypiifolia Euphorbiaceae chronic toxicity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats.
ISSN:	0102-695X 1981-528X
DOI:	10.1590/S0102-695X2012005000024