Search Results - "Oltvai, Z. N"

Global organization of metabolic fluxes in the bacterium Escherichia coli by Barabási, A.-L, Almaas, E, Kovács, B, Vicsek, T, Oltvai, Z. N

“…Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalysed biochemical reactions, is the most…”
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Lethality and centrality in protein networks by Barabási, A.-L, Oltvai, Z. N, Jeong, H, Mason, S. P

“…Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and…”
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Hierarchical Organization of Modularity in Metabolic Networks by Ravasz, E., Somera, A. L., Mongru, D. A., Oltvai, Z. N., A. -L. Barabási

“…Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building…”
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Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells by Tedeschi, P M, Markert, E K, Gounder, M, Lin, H, Dvorzhinski, D, Dolfi, S C, Chan, L L-Y, Qiu, J, DiPaola, R S, Hirshfield, K M, Boros, L G, Bertino, J R, Oltvai, Z N, Vazquez, A

“…Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction…”
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implications of human metabolic network topology for disease comorbidity by Lee, D.-S, Park, J, Kay, K.A, Christakis, N.A, Oltvai, Z.N, Barabási, A.-L

“…Most diseases are the consequence of the breakdown of cellular processes, but the relationships among genetic/epigenetic defects, the molecular interaction…”
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Evolutionary conservation of motif constituents in the yeast protein interaction network by Oltvai, Z N, Barabási, A-L, Wuchty, S

“…Understanding why some cellular components are conserved across species but others evolve rapidly is a key question of modern biology. Here we show that in…”
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The large-scale organization of metabolic networks by Tombor, B, Albert, R, Oltvai, Z. N, Jeong, H, Barabási, A.-L

“…In a cell or microorganism, the processes that generate mass, energy, information transfer and cell-fate specification are seamlessly integrated through a…”
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Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity by Beg, Q.K, Vazquez, A, Ernst, J, de Menezes, M.A, Bar-Joseph, Z, Barabási, A.-L, Oltvai, Z.N

“…The influence of the high intracellular concentration of macromolecules on cell physiology is increasingly appreciated, but its impact on system-level cellular…”
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The Topological Relationship between the Large-Scale Attributes and Local Interaction Patterns of Complex Networks by Vázquez, A, Dobrin, R, Sergi, D, Eckmann, J-P, Oltvai, Z N, Barabási, A-L

“…Recent evidence indicates that the abundance of recurring elementary interaction patterns in complex networks, often called subgraphs or motifs, carry…”
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Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655 by Gerdes, S Y, Scholle, M D, Campbell, J W, Balázsi, G, Ravasz, E, Daugherty, M D, Somera, A L, Kyrpides, N C, Anderson, I, Gelfand, M S, Bhattacharya, A, Kapatral, V, D'Souza, M, Baev, M V, Grechkin, Y, Mseeh, F, Fonstein, M Y, Overbeek, R, Barabási, A-L, Oltvai, Z N, Osterman, A L

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Topological Units of Environmental Signal Processing in the Transcriptional Regulatory Network of Escherichia coli by Balázsi, G., A.-L. Barabási, Oltvai, Z. N., Cantor, Charles R.

“…Recent evidence indicates that potential interactions within metabolic, protein-protein interaction, and transcriptional regulatory networks are used…”
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Blueprint for antimicrobial hit discovery targeting metabolic networks by Shen, Y, Liu, J, Estiu, G, Isin, B, Ahn, Y.Y, Lee, D.S, Barabási, A.L, Kapatral, V, Wiest, O, Oltvai, Z.N

“…Advances in genome analysis, network biology, and computational chemistry have the potential to revolutionize drug discovery by combining system-level…”
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Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assays by Henriksen, S.T., Liu, J., Estiu, G., Oltvai, Z.N., Wiest, O.

“…The rapid spread on multidrug-resistant strains of Staphylococcus aureus requires not just novel treatment options, but the development of faster methods for…”
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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax by Yin, Xiao-Ming, Oltvai, Zoltán N, Korsmeyer, Stanley J

“…Bcl-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma. Bcl-2 has the unique oncogenic role of extending cell survival by…”
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Bcl-2 functions in an antioxidant pathway to prevent apoptosis by Hockenbery, D M, Oltvai, Z N, Yin, X M, Milliman, C L, Korsmeyer, S J

“…Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality. Bcl-2 is localized to intracellular sites of oxygen free radical…”
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Multiple Bcl-2 Family Members Demonstrate Selective Dimerizations with Bax by Sedlak, Thomas W., Oltvai, Zoltan N., Yang, Elizabeth, Wang, Kun, Boise, Lawrence H., Thompson, Craig B., Korsmeyer, Stanley J.

“…A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to…”
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Comparable system-level organization of Archaea and Eukaryotes by Oltvai, Z.N, Szathmáry, E, Podani, J, Jeong, H, Tombor, B, Barabási, A.-L

“…A central and long-standing issue in evolutionary theory is the origin of the biological variation upon which natural selection acts. Some hypotheses suggest…”
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Network biology: understanding the cell's functional organization by Barabási, Albert-László, Oltvai, Zoltán N

“…A key aim of postgenomic biomedical research is to systematically catalogue all molecules and their interactions within a living cell. There is a clear need to…”
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Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus by MAI NGUYEN, BRANTON, P. E, WALTON, P. A, OLTVAI, Z. N, KORSMEYER, S. J, SHORE, G. C

“…Bcl-2 is an integral membrane protein that functions as a suppressor of programmed cell death. It contains a COOH-terminal signal anchor sequence that is…”
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Functional and topological characterization of protein interaction networks by Yook, Soon-Hyung, Oltvai, Zoltán N., Barabási, Albert-László

“…The elucidation of the cell's large‐scale organization is a primary challenge for post‐genomic biology, and understanding the structure of protein interaction…”
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