Search Results - "Olthof, M."

Minor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns by Olthof, Anouk M, Hyatt, Katery C, Kanadia, Rahul N

“…Mutations in minor spliceosome components such as U12 snRNA (cerebellar ataxia) and U4atac snRNA (microcephalic osteodysplastic primordial dwarfism type 1…”
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The patient's view on rare disease trial design - a qualitative study by Gaasterland, C M W, van der Weide, M C Jansen, du Prie-Olthof, M J, Donk, M, Kaatee, M M, Kaczmarek, R, Lavery, C, Leeson-Beevers, K, O'Neill, N, Timmis, O, van Nederveen, V, Vroom, E, van der Lee, J H

“…Clinical trials in rare diseases are more challenging than trials in frequent diseases. Small numbers of eligible trial participants, often complicated by…”
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Less meat in the shopping basket. The effect on meat purchases of higher prices, an information nudge and the combination: a randomised controlled trial by Vellinga, R E, Eykelenboom, M, Olthof, M R, Steenhuis, I H M, de Jonge, R, Temme, E H M

“…Reduced meat consumption benefits human and planetary health. Modelling studies have demonstrated the significant health and environmental gains that could be…”
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Introns: the "dark matter" of the eukaryotic genome by Girardini, Kaitlin N, Olthof, Anouk M, Kanadia, Rahul N

“…The emergence of introns was a significant evolutionary leap that is a major distinguishing feature between prokaryotic and eukaryotic genomes. While…”
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Publisher Correction: Less meat in the shopping basket: the effect on meat purchases of higher prices, an information nudge and the combination: a randomised controlled trial by Vellinga, R. E, Eykelenboom, M, Olthof, M. R, Steenhuis, I. H. M, de Jonge, R, Temme, E. H. M

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Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells by Baumgartner, Marybeth, Olthof, Anouk M, Aquino, Gabriela S, Hyatt, Katery C, Lemoine, Christopher, Drake, Kyle, Sturrock, Nikita, Nguyen, Nhut, Al Seesi, Sahar, Kanadia, Rahul N

“…Mutation in minor spliceosome components is linked to the developmental disorder microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1). Here, we…”
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Multiple Nonauditory Cortical Regions Innervate the Auditory Midbrain by Olthof, Bas M J, Rees, Adrian, Gartside, Sarah E

“…Our perceptual experience of sound depends on the integration of multiple sensory and cognitive domains, however the networks subserving this integration are…”
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Taxonomy of introns and the evolution of minor introns by Olthof, Anouk M, Schwoerer, Charles F, Girardini, Kaitlin N, Weber, Audrey L, Doggett, Karen, Mieruszynski, Stephen, Heath, Joan K, Moore, Timothy E, Biran, Jakob, Kanadia, Rahul N

“…Abstract Classification of introns, which is crucial to understanding their evolution and splicing, has historically been binary and has resulted in the naming…”
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Cost‐Effectiveness of Computer‐Assisted Cytology in a Primary hrHPV‐Based Cervical Cancer Screening Programme by Olthof, Ellen M. G., Kaljouw, S., Kemenade, Folkert J., Uyterlinde, Anne M., Kok, Inge M. C. M.

“…ABSTRACT Background Computer‐assisted screening (CAS) shows equal performance compared to manual screening, although results are heterogeneous. Furthermore,…”
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Puncta of Neuronal Nitric Oxide Synthase (nNOS) Mediate NMDA Receptor Signaling in the Auditory Midbrain by Olthof, Bas M J, Gartside, Sarah E, Rees, Adrian

“…Nitric oxide (NO) is a neurotransmitter synthesized in the brain by neuronal nitric oxide synthase (nNOS). Using immunohistochemistry and confocal imaging in…”
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Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women by Dalmeijer, G.W, Olthof, M.R, Verhoef, P, Bots, M.L, Schouw, Y.T. van der

“…Objective: To investigate the association between dietary intakes of folate, betaine and choline and the risk of cardiovascular disease (CVD). Design:…”
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Heritability of tic disorders: a twin-family study by Zilhão, N R, Olthof, M C, Smit, D J A, Cath, D C, Ligthart, L, Mathews, C A, Delucchi, K, Boomsma, D I, Dolan, C V

“…Genetic-epidemiological studies that estimate the contributions of genetic factors to variation in tic symptoms are scarce. We estimated the extent to which…”
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Concurrent participation in breast, cervical, and colorectal cancer screening in the Netherlands by Kregting, Lindy M., Olthof, Ellen M.G., Breekveldt, Emilie C.H., Aitken, Clare A., Heijnsdijk, Eveline A.M., Toes-Zoutendijk, Esther, de Koning, Harry J., van Ravesteyn, Nicolien T.

“…Many European countries offer organised population-based breast, cervical, and colorectal cancer screening programmes. Around age 55 and 60, Dutch women are…”
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Effects of betaine intake on plasma homocysteine concentrations and consequences for health by Olthof, M R, Verhoef, P

“…High plasma concentrations of homocysteine may increase risk of cardiovascular disease. Folic acid lowers plasma homocysteine by 25% maximally, because…”
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A survey of substance use for cognitive enhancement by university students in the Netherlands by Schelle, Kimberly J, Olthof, Bas M J, Reintjes, Wesley, Bundt, Carsten, Gusman-Vermeer, Joyce, van Mil, Anke C C M

“…Pharmacological cognitive enhancement, using chemicals to change cellular processes in the brain in order to enhance one's cognitive capacities, is an often…”
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Prospective associations of age at complementary feeding and exclusive breastfeeding duration with body mass index at 5–6 years within different risk groups by Sirkka, O., Vrijkotte, T., Halberstadt, J., Abrahamse‐Berkeveld, M., Hoekstra, T., Seidell, J., Olthof, M.

“…Summary Background Children with overweight or obesity are at risk for developing obesity in adulthood. Certain maternal characteristics, such as ethnicity,…”
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Disrupted minor intron splicing is prevalent in Mendelian disorders by Olthof, Anouk M., Rasmussen, Jeffrey S., Campeau, Philippe M., Kanadia, Rahul N.

“…Background Splicing is crucial for proper gene expression, and is predominately executed by the major spliceosome. Conversely, 722 introns in 699 human minor…”
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Actual and perceived nursing workload and the complexity of patients with total hip arthroplasty by Olthof, M., Stevens, M., Dijkstra, B., Bulstra, S.K., Van Den Akker-Scheek, I.

“…Little is known about the relation between patient complexity and nursing care of total hip arthroplasty (THA) patients. To improve patient care and hospital…”
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Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans by Olthof, M R, Hollman, P C, Vree, T B, Katan, M B

“…The flavonoid quercetin is an antioxidant which occurs in foods mainly as glycosides. The sugar moiety in quercetin glycosides affects their bioavailability in…”
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Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans by OLTHOF, Margreet R, HOLLMAN, Peter C, ZOCK, Peter L, KATAN, Martijn B

“…In population studies, high intakes of coffee are associated with raised concentrations of plasma homocysteine, a predictor of risk of cardiovascular disease…”
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