Search Results - "Olsthoorn, René C.L."

Group-specific structural features of the 5′-proximal sequences of coronavirus genomic RNAs by Chen, Shih-Cheng, Olsthoorn, René C.L

“…Abstract Global predictions of the secondary structure of coronavirus (CoV) 5′ untranslated regions and adjacent coding sequences revealed the presence of…”
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Relevance of the iron-responsive element (IRE) pseudotriloop structure for IRP1/2 binding and validation of IRE-like structures using the yeast three-hybrid system by Chen, Shih-Cheng, Olsthoorn, René C.L.

“…Iron-responsive elements (IREs) are ~35-nucleotide (nt) stem-loop RNA structures located in 5′ or 3′ untranslated regions (UTRs) of mRNAs that mediate…”
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Magnetic-Activated Cell Sorting Using Coiled-Coil Peptides: An Alternative Strategy for Isolating Cells with High Efficiency and Specificity by Shen, Meng-Jie, Olsthoorn, René C.L, Zeng, Ye, Bakkum, Thomas, Kros, Alexander, Boyle, Aimee L

“…Magnetic-activated cell sorting (MACS) is an affinity-based technique used to separate cells according to the presence of specific markers. Current MACS…”
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Investigating the correlation between Xrn1-resistant RNAs and frameshifter pseudoknots by Dilweg, Ivar W., Oskam, Megan G., Overbeek, Sophie, Olsthoorn, René C.L.

“…Xrn1-resistant RNA structures are multifunctional elements employed by an increasing number of RNA viruses. One of such elements is the coremin motif,…”
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Structural phylogenetic analysis reveals lineage-specific RNA repetitive structural motifs in all coronaviruses and associated variations in SARS-CoV-2 by Chen, Shih-Cheng, Olsthoorn, René C L, Yu, Chien-Hung

“…Abstract In many single-stranded (ss) RNA viruses, the cis-acting packaging signal that confers selectivity genome packaging usually encompasses short…”
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Conserved structural RNA domains in regions coding for cleavage site motifs in hemagglutinin genes of influenza viruses by Gultyaev, Alexander P, Richard, Mathilde, Spronken, Monique I, Olsthoorn, René C L, Fouchier, Ron A M

“…Abstract The acquisition of a multibasic cleavage site (MBCS) in the hemagglutinin (HA) glycoprotein is the main determinant of the conversion of low…”
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Stimulation of ribosomal frameshifting by antisense LNA by Yu, Chien-Hung, Noteborn, Mathieu H.M, Olsthoorn, René C.L

“…Programmed ribosomal frameshifting is a translational recoding mechanism commonly used by RNA viruses to express two or more proteins from a single mRNA at a…”
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Functional analysis of the SRV-1 RNA frameshifting pseudoknot by Olsthoorn, René C.L, Reumerman, Richard, Hilbers, Cornelis W, Pleij, Cornelis W.A, Heus, Hans A

“…Simian retrovirus type-1 uses programmed ribosomal frameshifting to control expression of the Gag-Pol polyprotein from overlapping gag and pol open-reading…”
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In vitro template-dependent synthesis of Pepino mosaic virus positive- and negative-strand RNA by its RNA-dependent RNA polymerase by Osman, Toba A.M., Olsthoorn, René C.L., Livieratos, Ioannis C.

“…► Pepino mosaic virus in vitro template-dependent system for the study of viral RNA synthesis was established. ► PepMV RdRp catalysed the conversion of…”
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conformational switch at the 3' end of a plant virus RNA regulates viral replication by Olsthoorn, R.C.L, Mertens, S, Brederode, F.T, Bol, J.F

“…3′ untranslated regions of alfamo‐ and ilar‐virus RNAs fold into a series of stem–loop structures to which the coat protein binds with high affinity. This…”
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Replication of alphaviruses requires a pseudoknot that involves the poly(A) tail by Olsthoorn, René C.L.

“…Alphaviruses, such as the Sindbis virus and the Chikungunya virus, are RNA viruses with a positive sense single-stranded RNA genome that infect various…”
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A database of flavivirus RNA structures with a search algorithm for pseudoknots and triple base interactions by Zammit, Alan, Helwerda, Leon, Olsthoorn, René C L, Verbeek, Fons J, Gultyaev, Alexander P

“…Abstract Motivation The Flavivirus genus includes several important pathogens, such as Zika, dengue and yellow fever virus. Flavivirus RNA genomes contain a…”
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Application of Coiled Coil Peptides in Liposomal Anticancer Drug Delivery Using a Zebrafish Xenograft Model by Yang, Jian, Shimada, Yasuhito, Olsthoorn, René C. L, Snaar-Jagalska, B. Ewa, Spaink, Herman P, Kros, Alexander

“…The complementary coiled coil forming peptides E4 [(EIAALEK)4] and K4 [(KIAALKE)4] are known to trigger liposomal membrane fusion when tethered to lipid…”
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G-quadruplexes within prion mRNA: the missing link in prion disease? by Olsthoorn, René C L

“…Cellular ribonucleic acid (RNA) plays a crucial role in the initial conversion of cellular prion protein PrP(C) to infectious PrP(Sc) or scrapie. The nature of…”
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Xrn1-resistant RNA motifs are disseminated throughout the RNA virome and are able to block scanning ribosomes by Dilweg, Ivar W., Peer, Jasper, Olsthoorn, René C. L.

“…RNAs that are able to prevent degradation by the 5’–3’ exoribonuclease Xrn1 have emerged as crucial structures during infection by an increasing number of RNA…”
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Drug Delivery via Cell Membrane Fusion Using Lipopeptide Modified Liposomes by Yang, Jian, Bahreman, Azadeh, Daudey, Geert, Bussmann, Jeroen, Olsthoorn, René C. L, Kros, Alexander

“…Efficient delivery of drugs to living cells is still a major challenge. Currently, most methods rely on the endocytotic pathway resulting in low delivery…”
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Stimulation of ribosomal frameshifting by RNA G-quadruplex structures by Yu, Chien-Hung, Teulade-Fichou, Marie-Paule, Olsthoorn, René C L

“…Guanine-rich sequences can fold into four-stranded structures of stacked guanine-tetrads, so-called G-quadruplexes (G4). These unique motifs have been…”
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All genera of Flaviviridae host a conserved Xrn1-resistant RNA motif by Dilweg, Ivar W., Savina, Anya, Köthe, Susanne, Gultyaev, Alexander P., Bredenbeek, Peter J., Olsthoorn, René C.L.

“…After infection by flaviviruses like Zika and West Nile virus, eukaryotic hosts employ the well-conserved endoribonuclease Xrn1 to degrade the viral genomic…”
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Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles by Yang, Jian, Tu, Jing, Lamers, Gerda E. M., Olsthoorn, René C. L., Kros, Alexander

“…Protein delivery into the cytosol of cells is a challenging topic in the field of nanomedicine, because cellular uptake and endosomal escape are typically…”
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Sense and nonsense DNA by Olsthoorn, René C.L, van Duin, Jan

“…Nucleotide sequences are routinely written in a 5' to 3' manner and, like this sentence, should be read from left to right to make sense. During processing of…”
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