Treatment of Pediatric Restless Legs Syndrome

Treatment of Pediatric Restless Legs Syndrome

Objective. The primary aim was to determine if iron supplementation effectively treats children with restless legs syndrome (RLS), the time to improvement or resolution of symptoms, and patient characteristics (family history of RLS, secondary sleep disorders, medical diagnoses, and/or mental health...

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Bibliographic Details
Published in:Clinical pediatrics Vol. 53; no. 4; pp. 331 - 336
Main Authors: Amos, Louella B., Grekowicz, Megan L., Kuhn, Evelyn M., Olstad, Jenna D., Collins, Maureen M., Norins, Nan A., D’Andrea, Lynn A.
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-04-2014
Westminster Publications, Inc
Subjects:
Adolescent
Amines - therapeutic use
Analgesics - therapeutic use
Anticonvulsants - therapeutic use
Antioxidants - therapeutic use
Benzothiazoles - therapeutic use
Child
Child, Preschool
Children & youth
Clonidine - therapeutic use
Cyclohexanecarboxylic Acids - therapeutic use
Dopamine Agonists - therapeutic use
Drug Therapy, Combination - methods
Female
gamma-Aminobutyric Acid - therapeutic use
Humans
Indoles - therapeutic use
Iron
Iron - therapeutic use
Male
Medical treatment
Melatonin - therapeutic use
Mental Disorders - complications
Pediatrics
Polysomnography - methods
Restless Legs Syndrome - complications
Restless Legs Syndrome - drug therapy
Retrospective Studies
Sleep disorders
Sleep Wake Disorders - complications
Treatment Outcome
United States > US
Milwaukee Wisconsin
treatment
iron
ferritin
restless legs syndrome
pediatric
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Summary:Objective. The primary aim was to determine if iron supplementation effectively treats children with restless legs syndrome (RLS), the time to improvement or resolution of symptoms, and patient characteristics (family history of RLS, secondary sleep disorders, medical diagnoses, and/or mental health diagnoses) that may affect outcome. Methods. This was a retrospective chart review of children between 5 and 18 years old who were diagnosed with RLS at the pediatric sleep disorders clinic at Children’s Hospital of Wisconsin in Milwaukee, Wisconsin. Documented RLS treatment approaches included supplemental iron, nonpharmacologic interventions, melatonin, gabapentin, clonidine, and dopamine agonists (pramipexole and ropinirole). Results. Ninety-seven children were diagnosed with RLS; 60.8% of children were between 5 and 11 years old. Most children (65%) received iron either as monotherapy or in combination with other treatments. Approximately 80% of the children who received iron and had follow-up had improvement or resolution of their symptoms. The median baseline ferritin level was 22.7 ng/mL, and 71% of children had a ferritin level less than 30 ng/mL. The median time to improvement or resolution of symptoms was 3.8 months. Conclusions. Supplemental iron as monotherapy or in combination with other treatments is effective in treating pediatric RLS. A prospective study could help determine if the initial ferritin level and degree of change in the ferritin level impact response to iron treatment. It is also important to study the long-term outcomes in these patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0009-9228
1938-2707
DOI:10.1177/0009922813507997