Search Results - "Olson, Timothy M"

Human KATP channelopathies: diseases of metabolic homeostasis by Olson, Timothy M., Terzic, Andre

“…Assembly of an inward rectifier K + channel pore (Kir6.1/Kir6.2) and an adenosine triphosphate (ATP)-binding regulatory subunit (SUR1/SUR2A/SUR2B) forms…”
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Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy by Brauch, Katharine M., MS, Karst, Margaret L., BA, Herron, Kathleen J., BA, de Andrade, Mariza, PhD, Pellikka, Patricia A., MD, Rodeheffer, Richard J., MD, Michels, Virginia V., MD, Olson, Timothy M., MD

“…Objectives We sought to identify a novel gene for dilated cardiomyopathy (DCM). Background DCM is a heritable, genetically heterogeneous disorder that remains…”
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RG flows in d dimensions, the dilaton effective action, and the a-theorem by Elvang, Henriette, Olson, Timothy M.

“…A bstract Motivated by the recent dilaton-based proof of the 4d a -theorem, we study the dilaton effective action for RG flows in d dimensions. When d is even,…”
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Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation by OLSON, Timothy M, ALEKSEEV, Alexey E, LIU, Xiaoke K, PARK, Sungjo, ZINGMAN, Leonid V, BIENENGRAEBER, Martin, SATTIRAJU, Srinivasan, BALLEW, Jeffrey D, JAHANGIR, Arshad, TERZIC, Andre

“…Atrial fibrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac atria. Predisposing to stroke and heart failure, this common…”
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Idiopathic Restrictive Cardiomyopathy in Children and Young Adults by Anderson, Heather N., Cetta, Frank, Driscoll, David J., Olson, Timothy M., Ackerman, Michael J., Johnson, Jonathan N.

“…Idiopathic restrictive cardiomyopathy (IRC) is a rare condition characterized by reduced ventricular compliance. Children with IRC have poor outcomes with most…”
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Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish by Shih, Yu-Huan, Zhang, Yuji, Ding, Yonghe, Ross, Christian A, Li, Hu, Olson, Timothy M, Xu, Xiaolei

“…BACKGROUND—Genetic studies of cardiomyopathy and heart failure have limited throughput in mammalian models. Adult zebrafish have been recently pursued as a…”
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Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation by Hodgson-Zingman, Denice M, Karst, Margaret L, Zingman, Leonid V, Heublein, Denise M, Darbar, Dawood, Herron, Kathleen J, Ballew, Jeffrey D, de Andrade, Mariza, Burnett, John C, Olson, Timothy M

“…In a family with hereditary atrial fibrillation, linkage analysis and candidate-gene sequencing identified a frameshift mutation in the atrial natriuretic…”
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Regenerative therapy for hypoplastic left heart syndrome: First report of intraoperative intramyocardial injection of autologous umbilical-cord blood–derived cells by Burkhart, Harold M., MD, Qureshi, Muhammad Yasir, MBBS, Peral, Susana Cantero, MD, O'Leary, Patrick W., MD, Olson, Timothy M., MD, Cetta, Frank, MD, Nelson, Timothy J., MD, PhD

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Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy by Beraldi, Rosanna, Li, Xing, Martinez Fernandez, Almudena, Reyes, Santiago, Secreto, Frank, Terzic, Andre, Olson, Timothy M, Nelson, Timothy J

“…Dilated cardiomyopathy (DCM) due to mutations in RBM20, a gene encoding an RNA-binding protein, is associated with high familial penetrance, risk of…”
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Sodium Channel Mutations and Susceptibility to Heart Failure and Atrial Fibrillation by Olson, Timothy M, Michels, Virginia V, Ballew, Jeffrey D, Reyna, Sandra P, Karst, Margaret L, Herron, Kathleen J, Horton, Steven C, Rodeheffer, Richard J, Anderson, Jeffrey L

“…CONTEXT Dilated cardiomyopathy (DCM), a genetically heterogeneous disorder, causes heart failure and rhythm disturbances. The majority of identified DCM genes…”
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Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity by Birker, Katja, Ge, Shuchao, Kirkland, Natalie J, Theis, Jeanne L, Marchant, James, Fogarty, Zachary C, Missinato, Maria A, Kalvakuri, Sreehari, Grossfeld, Paul, Engler, Adam J, Ocorr, Karen, Nelson, Timothy J, Colas, Alexandre R, Olson, Timothy M, Vogler, Georg, Bodmer, Rolf

“…Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic…”
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Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome by Theis, Jeanne L, Vogler, Georg, Missinato, Maria A, Li, Xing, Nielsen, Tanja, Zeng, Xin-Xin I, Martinez-Fernandez, Almudena, Walls, Stanley M, Kervadec, Anaïs, Kezos, James N, Birker, Katja, Evans, Jared M, O'Byrne, Megan M, Fogarty, Zachary C, Terzic, André, Grossfeld, Paul, Ocorr, Karen, Nelson, Timothy J, Olson, Timothy M, Colas, Alexandre R, Bodmer, Rolf

“…Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary…”
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Whole Genome Sequencing in Hypoplastic Left Heart Syndrome by Theis, Jeanne L, Olson, Timothy M

“…Hypoplastic left heart syndrome (HLHS) is a genetically complex disorder. Whole genome sequencing enables comprehensive scrutiny of single nucleotide variants…”
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Transcriptional atlas of cardiogenesis maps congenital heart disease interactome by Li, Xing, Martinez-Fernandez, Almudena, Hartjes, Katherine A, Kocher, Jean-Pierre A, Olson, Timothy M, Terzic, Andre, Nelson, Timothy J

“…Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart…”
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TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy by Kim, Maengjo, Lu, Linghui, Dvornikov, Alexey V., Ma, Xiao, Ding, Yonghe, Zhu, Ping, Olson, Timothy M., Lin, Xueying, Xu, Xiaolei

“…A de novo missense variant in Rag GTPase protein C (RagCS75Y) was recently identified in a syndromic dilated cardiomyopathy (DCM) patient. However, its…”
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TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy by Theis, Jeanne L, Zimmermann, Michael T, Larsen, Brandon T, Rybakova, Inna N, Long, Pamela A, Evans, Jared M, Middha, Sumit, de Andrade, Mariza, Moss, Richard L, Wieben, Eric D, Michels, Virginia V, Olson, Timothy M

“…Locus mapping has uncovered diverse etiologies for familial atrial fibrillation (AF), dilated cardiomyopathy (DCM), and mixed cardiac phenotype syndromes, yet…”
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A Genetic Variant of the Atrial Natriuretic Peptide Gene Is Associated With Cardiometabolic Protection in the General Community by Cannone, Valentina, MD, PhD, Boerrigter, Guido, MD, Cataliotti, Alessandro, MD, PhD, Costello-Boerrigter, Lisa C., MD, PhD, Olson, Timothy M., MD, McKie, Paul M., MD, Heublein, Denise M., CLT, Lahr, Brian D., MS, Bailey, Kent R., PhD, Averna, Maurizio, MD, PhD, Redfield, Margaret M., MD, Rodeheffer, Richard J., MD, Burnett, John C., MD

“…Objectives We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene. Background…”
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Familial Incidence of Cardiovascular Malformations in Hypoplastic Left Heart Syndrome by Kelle, Angela M., MD, Qureshi, Muhammad Y., MBBS, Olson, Timothy M., MD, Eidem, Benjamin W., MD, O'Leary, Patrick W., MD

“…Obstructive left-sided congenital heart lesions exhibit familial clustering, and familial echocardiographic screening for bicuspid aortic valve has become…”
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Diagnostic Yield of Whole Exome Sequencing in Pediatric Dilated Cardiomyopathy by Long, Pamela A, Evans, Jared M, Olson, Timothy M

“…Dilated cardiomyopathy (DCM) is a heritable, genetically heterogeneous disorder characterized by progressive heart failure. DCM typically remains clinically…”
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ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating by BIENENGRAEBER, Martin, OLSON, Timothy M, PANG, Yuan-Ping, ALEKSEEV, Alexey E, TERZIC, Andre, SELIVANOV, Vitaliy A, KATHMANN, Eva C, O'COCHLAIN, Fearghas, FAN GAO, KARGER, Amy B, BALLEW, Jeffrey D, HODGSON, Denice M, ZINGMAN, Leonid V

“…Stress tolerance of the heart requires high-fidelity metabolic sensing by ATP-sensitive potassium (K(ATP)) channels that adjust membrane potential-dependent…”
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