Search Results - "Olson, Matthew R."

Effector T Helper Cell Subsets in Inflammatory Bowel Diseases by Imam, Tanbeena, Park, Sungtae, Kaplan, Mark H, Olson, Matthew R

“…The gastrointestinal tract is a site of high immune challenge, as it must maintain a delicate balance between tolerating luminal contents and generating an…”
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Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation by Russ, Brendan E., Olshanksy, Moshe, Smallwood, Heather S., Li, Jasmine, Denton, Alice E., Prier, Julia E., Stock, Angus T., Croom, Hayley A., Cullen, Jolie G., Nguyen, Michelle L.T., Rowe, Stephanie, Olson, Matthew R., Finkelstein, David B., Kelso, Anne, Thomas, Paul G., Speed, Terry P., Rao, Sudha, Turner, Stephen J.

“…The molecular mechanisms that regulate the rapid transcriptional changes that occur during cytotoxic T lymphocyte (CTL) proliferation and differentiation in…”
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Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation by Cheung, Ka Lung, Zhang, Fan, Jaganathan, Anbalagan, Sharma, Rajal, Zhang, Qiang, Konuma, Tsuyoshi, Shen, Tong, Lee, June-Yong, Ren, Chunyan, Chen, Chih-Hung, Lu, Geming, Olson, Matthew R., Zhang, Weijia, Kaplan, Mark H., Littman, Dan R., Walsh, Martin J., Xiong, Huabao, Zeng, Lei, Zhou, Ming-Ming

“…The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this…”
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Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host-Virus Interactions by Chakravorty, Srishti, Yan, Bingyu, Wang, Chong, Wang, Luopin, Quaid, Joseph Taylor, Lin, Chin Fang, Briggs, Scott D, Majumder, Joydeb, Canaria, D Alejandro, Chauss, Daniel, Chopra, Gaurav, Olson, Matthew R, Zhao, Bo, Afzali, Behdad, Kazemian, Majid

“…Epstein-Barr virus (EBV) is a complex oncogenic symbiont. The molecular mechanisms governing EBV carcinogenesis remain elusive and the functional interactions…”
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Tox induces T cell IL-10 production in a BATF-dependent manner by Canaria, D Alejandro, Rodriguez, J Alejandra, Wang, Luopin, Yeo, Franklin J, Yan, Bingyu, Wang, Mengbo, Campbell, Charlotte, Kazemian, Majid, Olson, Matthew R

“…Tox is a member of the high mobility group (HMG)-Box transcription factors and plays important roles in thymic T cell development. Outside of the thymus,…”
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Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function by Russ, Brendan E., Olshansky, Moshe, Li, Jasmine, Nguyen, Michelle L.T., Gearing, Linden J., Nguyen, Thi H.O., Olson, Matthew R., McQuilton, Hayley A., Nüssing, Simone, Khoury, Georges, Purcell, Damian F.J., Hertzog, Paul J., Rao, Sudha, Turner, Stephen J.

“…Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the gene regulatory mechanisms that…”
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STAT3 Activation Impairs the Stability of Th9 Cells by Ulrich, Benjamin J, Verdan, Felipe Fortino, McKenzie, Andrew N J, Kaplan, Mark H, Olson, Matthew R

“…Th9 cells regulate multiple immune responses, including immunity to pathogens and tumors, allergic inflammation, and autoimmunity. Despite ongoing research…”
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IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6 by Canaria, D Alejandro, Clare, Maia G, Yan, Bingyu, Campbell, Charlotte B, Ismaio, Zachariah A, Anderson, Nicole L, Park, Sungtae, Dent, Alexander L, Kazemian, Majid, Olson, Matthew R

“…IL-9-producing CD4 T helper cells, termed Th9 cells, differentiate from naïve precursor cells in response to a combination of cytokine and cell surface…”
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Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control Candida albicans in the Intestine by Datta, Abhishek, Hernandez-Franco, Juan F., Park, Sungtae, Olson, Matthew R., HogenEsch, Harm, Thangamani, Shankar

“…Invasive Candida albicans (CA) infections often arise from the intestine and cause life-threatening infections in immunocompromised individuals. The role of…”
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Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomics by Ran, Ran, Muñoz Briones, Javier, Jena, Smrutiti, Anderson, Nicole L., Olson, Matthew R., Green, Leopold N., Brubaker, Douglas K.

“…The co-culture of two adult human colorectal cancer cell lines, Caco-2 and HT29, on Transwell is commonly used as an in vitro gut mimic, yet the…”
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Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses by Bird, Nicola L, Olson, Matthew R, Hurt, Aeron C, Oshansky, Christine M, Oh, Ding Yuan, Reading, Patrick C, Chua, Brendon Y, Sun, Yilun, Tang, Li, Handel, Andreas, Jackson, David C, Turner, Stephen J, Thomas, Paul G, Kedzierska, Katherine

“…CD8(+) T cells directed against conserved viral regions elicit broad immunity against distinct influenza viruses, promote rapid virus elimination and enhanced…”
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The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection by Olson, Matthew R, McDermott, Daniel S, Varga, Steven M

“…Lymphocytic choriomeningitis virus (LCMV) causes a systemic infection in mice with virus replication occurring in both peripheral tissues and secondary…”
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The development and in vivo function of T helper 9 cells by Kaplan, Mark H., Hufford, Matthew M., Olson, Matthew R.

“…Key Points Although interleukin-9 (IL-9) is produced by several types of immune cells, IL-9-secreting T helper 9 (T H 9) cells are a predominant source of IL-9…”
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Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses by Denton, Alice E, Wesselingh, Robb, Gras, Stephanie, Guillonneau, Carole, Olson, Matthew R, Mintern, Justine D, Zeng, Weiguang, Jackson, David C, Rossjohn, Jamie, Hodgkin, Philip D, Doherty, Peter C, Turner, Stephen J

“…High-avidity interactions between TCRs and peptide + class I MHC (pMHCI) epitopes drive CTL activation and expansion. Intriguing questions remain concerning…”
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Granzyme A-producing T helper cells are critical for acute graft-versus-host disease by Park, Sungtae, Griesenauer, Brad, Jiang, Hua, Adom, Djamilatou, Mehrpouya-Bahrami, Pegah, Chakravorty, Srishti, Kazemian, Majid, Imam, Tanbeena, Srivastava, Rajneesh, Hayes, Tristan A, Pardo, Julian, Janga, Sarath Chandra, Paczesny, Sophie, Kaplan, Mark H, Olson, Matthew R

“…Acute graft-versus-host disease (aGVHD) can occur after hematopoietic cell transplant in patients undergoing treatment for hematological malignancies or inborn…”
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Differential Role of Gamma Interferon in Inhibiting Pulmonary Eosinophilia and Exacerbating Systemic Disease in Fusion Protein-Immunized Mice Undergoing Challenge Infection with Respiratory Syncytial Virus by CASTILOW, Elaine M, OLSON, Matthew R, MEYERHOLZ, David K, VARGA, Steven M

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Regulation of Cytokine Production by Virus-Specific CD8 T Cells in the Lungs by FULTON, Ross B, OLSON, Matthew R, VARGA, Steven M

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Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation by Russ, Brendan E., Olshanksy, Moshe, Smallwood, Heather S., Li, Jasmine, Denton, Alice E., Prier, Julia E., Stock, Angus T., Croom, Hayley A., Cullen, Jolie G., Nguyen, Michelle L.T., Rowe, Stephanie, Olson, Matthew R., Finkelstein, David B., Kelso, Anne, Thomas, Paul G., Speed, Terry P., Rao, Sudha, Turner, Stephen J.

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Epstein-Barr Virus Episome Physically Interacts with Active Regions of the Host Genome in Lymphoblastoid Cells by Wang, Luopin, Laing, Jun, Yan, Bingyu, Zhou, Hufeng, Ke, Liangru, Wang, Chong, Narita, Yohei, Zhang, Zonghao, Olson, Matthew R, Afzali, Behdad, Zhao, Bo, Kazemian, Majid

“…The Epstein-Barr virus (EBV) episome is known to interact with the three-dimensional structure of the human genome in infected cells. However, the exact…”
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Activin A Promotes Differentiation of a Pathogenic Multicytokine IL-9-secreting CD4+ T Cell Population by Ulrich, Benjamin J, Zhang, Wenwu, Kenworthy, Blake T, Kharwadkar, Rakshin, Olson, Matthew R, Kaplan, Mark H

“…The development of Th subsets results from cellular and cytokine cues that are present in the inflammatory environment. The developing T cell integrates…”
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