Search Results - "Olson, Emilia S."

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases by Olson, Emilia S, Jiang, Tao, Aguilera, Todd A, Nguyen, Quyen T, Ellies, Lesley G, Scadeng, Miriam, Tsien, Roger Y

“…High-resolution imaging of molecules intrinsically involved in malignancy and metastasis would be of great value for clinical detection and staging of tumors…”
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Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival by Nguyen, Quyen T, Olson, Emilia S, Aguilera, Todd A, Jiang, Tao, Scadeng, Miriam, Ellies, Lesley G, Tsien, Roger Y

“…The completeness of tumor removal during surgery is dependent on the surgeon's ability to differentiate tumor from normal tissue using subjective criteria that…”
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Tumor Imaging by Means of Proteolytic Activation of Cell-Penetrating Peptides by Jiang, Tao, Olson, Emilia S., Nguyen, Quyen T., Roy, Melinda, Jennings, Patricia A., Tsien, Roger Y.

“…We have devised and tested a new strategy for selectively delivering molecules to tumor cells. Cellular association of polyarginine-based, cell-penetrating…”
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Early detection of thrombin activity in neuroinflammatory disease by Davalos, Dimitrios, Baeten, Kim M., Whitney, Michael A., Mullins, Eric S., Friedman, Beth, Olson, Emilia S., Ryu, Jae Kyu, Smirnoff, Dimitri S., Petersen, Mark A., Bedard, Catherine, Degen, Jay L., Tsien, Roger Y., Akassoglou, Katerina

“…Although multiple sclerosis (MS) has been associated with the coagulation system, the temporal and spatial regulation of coagulation activity in…”
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Molecular Imaging of the Glomerulus via Mesangial Cell Uptake of Radiolabeled Tilmanocept by Qin, Zhengtao, Hoh, Carl K, Olson, Emilia S, Jahromi, Amin Haghighat, Hall, David J, Barback, Christopher V, You, Young-Hyun, Yanagita, Motoko, Sharma, Kumar, Vera, David R

“…An unmet need for the clinical management of chronic kidney disease is a predictive tool of kidney function during the first decade of the disease, when there…”
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Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke by Chen, Shanyan, Cui, Jiankun, Jiang, Tao, Olson, Emilia S, Cai, Quan-Yu, Yang, Ming, Wu, Wei, Guthrie, James M, Robertson, JD, Lipton, Stuart A, Ma, Lixin, Tsien, Roger Y, Gu, Zezong

“…Matrix metalloproteinases (MMPs), particularly gelatinases (MMP-2/-9), are involved in neurovascular impairment after stroke. Detection of gelatinase activity…”
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Parallel in Vivo and in Vitro Selection Using Phage Display Identifies Protease-dependent Tumor-targeting Peptides by Whitney, Mike, Crisp, Jessica L., Olson, Emilia S., Aguilera, Todd A., Gross, Larry A., Ellies, Lesley G., Tsien, Roger Y.

“…We recently developed activatable cell-penetrating peptides (ACPPs) that target contrast agents to in vivo sites of matrix metalloproteinase activity, such as…”
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Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent by Malone, Christopher D, Olson, Emilia S, Mattrey, Robert F, Jiang, Tao, Tsien, Roger Y, Nguyen, Quyen T

“…The ability to detect small malignant lesions with magnetic resonance imaging (MRI) is limited by inadequate accumulations of Gd with standard chelate agents…”
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Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension by Critser, Paul J, Higano, Nara S, Tkach, Jean A, Olson, Emilia S, Spielberg, David R, Kingma, Paul S, Fleck, Robert J, Lang, Sean M, Moore, Ryan A, Taylor, Michael D, Woods, Jason C

“…Patients with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) have increased morbidity and mortality. Noninvasive assessment relies on…”
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Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging by Olson, Emilia S, Orozco, Jahir, Wu, Zhe, Malone, Christopher D, Yi, Boemha, Gao, Wei, Eghtedari, Mohammad, Wang, Joseph, Mattrey, Robert F

“…Abstract We present a new class of ultrasound molecular imaging agents that extend upon the design of micromotors that are designed to move through fluids by…”
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Thrombin activity associated with neuronal damage during acute focal ischemia by Chen, Bo, Friedman, Beth, Whitney, Michael A, Winkle, Jessica A Van, Lei, I-Farn, Olson, Emilia S, Cheng, Qun, Pereira, Benedict, Zhao, Lifu, Tsien, Roger Y, Lyden, Patrick D

“…Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to…”
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Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides by Aguilera, Todd A, Olson, Emilia S, Timmers, Margaret M, Jiang, Tao, Tsien, Roger Y

“…Cell penetrating peptides (CPPs) have been developed as vehicles for payload delivery into cells in culture and in animals. However several biologic features…”
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In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer by Olson, Emilia S, Aguilera, Todd A, Jiang, Tao, Ellies, Lesley G, Nguyen, Quyen T, Wong, Edmund H, Gross, Larry A, Tsien, Roger Y

“…Activatable cell penetrating peptides (ACPPs) are novel in vivo targeting agents comprised of a polycationic cell penetrating peptide (CPP) connected via a…”
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Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles by Olson, Emilia S., Ortac, Inanc, Malone, Christopher, Esener, Sadik, Mattrey, Robert

“…Oxidative stress is a powerful tool that is critical to immune mediated responses in healthy individuals, yet additionally plays a crucial role in development…”
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Neural progenitor cells labeling with microbubble contrast agent for ultrasound imaging in vivo by Cui, Wenjin, Tavri, Sidhartha, Benchimol, Michael J, Itani, Malak, Olson, Emilia S, Zhang, Hong, Decyk, Marika, Ramirez, Rosemarie G, Barback, Christopher V, Kono, Yuko, Mattrey, Robert F

“…Abstract Tracking neuroprogenitor cells (NPCs) that are used to target tumors, infarction or inflammation, is paramount for cell-based therapy. We employed…”
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Oxidative Stress: Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles (Adv. Healthcare Mater. 5/2017) by Olson, Emilia S., Ortac, Inanc, Malone, Christopher, Esener, Sadik, Mattrey, Robert

“…Inanc Ortac, Emilia S. Olson, Robert Mattrey, and co‐workers introduce an intravenously injectable probe labeling sites of oxidative injury in vivo in article…”
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In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity by Olson, Emilia S, Whitney, Michael A, Friedman, Beth, Aguilera, Todd A, Crisp, Jessica L, Baik, Fred M, Jiang, Tao, Baird, Stephen M, Tsimikas, Sotirios, Tsien, Roger Y, Nguyen, Quyen T

“…Thrombin and other coagulation enzymes have been shown to be important during atherosclerotic disease development. Study of these proteases is currently…”
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Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer Molecular Imaging Agent by Malone, Christopher D, Olson, Emilia S, Mattrey, Robert F, Jiang, Tao, Tsien, Roger Y, Nguyen, Quyen T

“…The ability to detect small malignant lesions with magnetic resonance imaging (MRI) is limited by inadequate accumulations of Gd with standard chelate agents…”
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Abstract IA1: Building molecules to guide anticancer therapy by Olson, Emilia S., Tsien, Roger Y., Savariar, Elamprakash N., Crisp, Jessica L., Jiang, Tao, Aguilera, Todd A., Whitney, Mike A., Steinbach, Paul, Ellies, Lesley G., Nguyen, Quyen T.

“…For clinical imaging, we need synthetic molecules with novel amplifying mechanisms for homing to diseased tissues. Activatable cell penetrating peptides…”
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In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activityElectronic supplementary information (ESI) available. See DOI: 10.1039/c2ib00161f by Olson, Emilia S, Whitney, Michael A, Friedman, Beth, Aguilera, Todd A, Crisp, Jessica L, Baik, Fred M, Jiang, Tao, Baird, Stephen M, Tsimikas, Sotirios, Tsien, Roger Y, Nguyen, Quyen T

“…Thrombin and other coagulation enzymes have been shown to be important during atherosclerotic disease development. Study of these proteases is currently…”
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