Search Results - "Olshevskaya, Elena V."

A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration by Peshenko, Igor V., Cideciyan, Artur V., Sumaroka, Alexander, Olshevskaya, Elena V., Scholten, Alexander, Abbas, Seher, Koch, Karl-Wilhelm, Jacobson, Samuel G., Dizhoor, Alexander M.

“…The guanylyl cyclase-activating protein, GCAP1, activates photoreceptor membrane guanylyl cyclase (RetGC) in the light, when free Ca2+ concentrations decline,…”
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Structure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State by Lim, Sunghyuk, Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M., Ames, James B.

“…GCAP1, a member of the neuronal calcium sensor subclass of the calmodulin superfamily, confers Ca2+-sensitive activation of retinal guanylyl cyclase 1…”
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Mg²⁺/Ca²⁺ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase by Dizhoor, Alexander M, Olshevskaya, Elena V, Peshenko, Igor V

“…Photon absorption by photoreceptors activates hydrolysis of cGMP, which shuts down cGMP-gated channels and decreases free Ca²⁺ concentrations in outer segment…”
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Enzymatic Properties and Regulation of the Native Isozymes of Retinal Membrane Guanylyl Cyclase (RetGC) from Mouse Photoreceptors by Peshenko, Igor V, Olshevskaya, Elena V, Savchenko, Andrey B, Karan, Sukanya, Palczewski, Krzysztof, Baehr, Wolfgang, Dizhoor, Alexander M

“…Mouse photoreceptor function and survival critically depend on Ca2+-regulated retinal membrane guanylyl cyclase (RetGC), comprised of two isozymes, RetGC1 and…”
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Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice by Makino, Clint L, Wen, Xiao-Hong, Olshevskaya, Elena V, Peshenko, Igor V, Savchenko, Andrey B, Dizhoor, Alexander M

“…Regulation of cGMP synthesis by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) in rod and cone photoreceptors by calcium-sensitive guanylyl…”
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GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone–rod dystrophy but not for stationary night blindness by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging…”
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Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…Different forms of photoreceptor degeneration cause blindness. Retinal degeneration-3 protein (RD3) deficiency in photoreceptors leads to recessive congenital…”
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The Y99C Mutation in Guanylyl Cyclase-Activating Protein 1 Increases Intracellular Ca2+ and Causes Photoreceptor Degeneration in Transgenic Mice by Olshevskaya, Elena V, Calvert, Peter D, Woodruff, Michael L, Peshenko, Igor V, Savchenko, Andrey B, Makino, Clint L, Ho, Ye-Shih, Fain, Gordon L, Dizhoor, Alexander M

“…Guanylyl cyclase-activating proteins (GCAPs) are Ca2+-binding proteins that activate guanylyl cyclase when free Ca2+ concentrations in retinal rods and cones…”
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Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness by Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.

“…Deficiency of RD3 (retinal degeneration 3) protein causes recessive blindness and photoreceptor degeneration in humans and in the rd3 mouse strain, but the…”
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Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…Retinal degeneration 3 (RD3) protein, essential for normal expression of retinal membrane guanylyl cyclase (RetGC) in photoreceptor cells, blocks RetGC…”
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Retinal degeneration-3 protein promotes photoreceptor survival by suppressing activation of guanylyl cyclase rather than accelerating GMP recycling by Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.

“…Retinal degeneration-3 protein (RD3) deficiency causes photoreceptor dysfunction and rapid degeneration in the rd3 mouse strain and in human Leber’s congenital…”
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GUCY2D Cone-Rod Dystrophy-6 Is a "Phototransduction Disease" Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1 by Sato, Shinya, Peshenko, Igor V, Olshevskaya, Elena V, Kefalov, Vladimir J, Dizhoor, Alexander M

“…The Arg838Ser mutation in retinal membrane guanylyl cyclase 1 (RetGC1) has been linked to autosomal dominant cone-rod dystrophy type 6 (CORD6). It is believed…”
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Interaction of GCAP1 with retinal guanylyl cyclase and calcium: sensitivity to fatty acylation by Peshenko, Igor V, Olshevskaya, Elena V, Dizhoor, Alexander M

“…Guanylyl cyclase activating proteins (GCAPs) are calcium/magnesium binding proteins within neuronal calcium sensor proteins group (NCS) of the EF-hand proteins…”
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The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice by Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.

“…Substitutions of Arg838 in the dimerization domain of a human retinal membrane guanylyl cyclase 1 (RetGC1) linked to autosomal dominant cone-rod degeneration…”
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Evaluating the Role of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Domains in Binding Guanylyl Cyclase-activating Proteins (GCAPs) by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…Retinal membrane guanylyl cyclase 1 (RetGC1) regulated by guanylyl cyclase-activating proteins (GCAPs) controls photoreceptor recovery and when mutated causes…”
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Dimerization Domain of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Is an Essential Part of Guanylyl Cyclase-activating Protein (GCAP) Binding Interface by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…The photoreceptor-specific proteins guanylyl cyclase-activating proteins (GCAPs) bind and regulate retinal membrane guanylyl cyclase 1 (RetGC1) but not…”
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Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark by Liu, Xiaoqing, Pawlyk, Basil S, Adamian, Michael, Olshevskaya, Elena V, Dizhoor, Alexander M, Makino, Clint L, Li, Tiansen

“…In one group of gene mutations that cause photoreceptor degeneration in human patients, guanylyl cyclase is overactive in the dark. The ensuing excess opening…”
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Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human Leber congenital amaurosis en route to therapy: residual cone-photoreceptor vision correlates with biochemical properties of the mutants by Jacobson, Samuel G, Cideciyan, Artur V, Peshenko, Igor V, Sumaroka, Alexander, Olshevskaya, Elena V, Cao, Lihui, Schwartz, Sharon B, Roman, Alejandro J, Olivares, Melani B, Sadigh, Sam, Yau, King-Wai, Heon, Elise, Stone, Edwin M, Dizhoor, Alexander M

“…The GUCY2D gene encodes retinal membrane guanylyl cyclase (RetGC1), a key component of the phototransduction machinery in photoreceptors. Mutations in GUCY2D…”
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Identification of Target Binding Site in Photoreceptor Guanylyl Cyclase-activating Protein 1 (GCAP1) by Peshenko, Igor V., Olshevskaya, Elena V., Lim, Sunghyuk, Ames, James B., Dizhoor, Alexander M.

“…Retinal guanylyl cyclase (RetGC)-activating proteins (GCAPs) regulate visual photoresponse and trigger congenital retinal diseases in humans, but GCAP…”
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Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors by Olshevskaya, Elena V, Peshenko, Igor V, Savchenko, Andrey B, Dizhoor, Alexander M

“…Two calcium-sensitive guanylyl cyclase activating proteins (GCAP1 and GCAP2) activate cGMP synthesis in photoreceptor by retinal membrane guanylyl cyclase…”
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