Search Results - "Olsen, Timothy R."

Peak MSC-Are We There Yet? by Olsen, Timothy R, Ng, Kelvin S, Lock, Lye T, Ahsan, Tabassum, Rowley, Jon A

“…Human mesenchymal stem cells (hMSCs) are a critical raw material for many regenerative medicine products, including cell-based therapies, engineered tissues,…”
Get full text

Bioreactor Parameters for Microcarrier-Based Human MSC Expansion under Xeno-Free Conditions in a Vertical-Wheel System by Lembong, Josephine, Kirian, Robert, Takacs, Joseph D, Olsen, Timothy R, Lock, Lye Theng, Rowley, Jon A, Ahsan, Tabassum

“…Human mesenchymal stem/stromal cells (hMSCs) have been investigated and proven to be a well-tolerated, safe therapy for a variety of indications, as shown by…”
Get full text

Integrated Microfluidic Isolation of Aptamers Using Electrophoretic Oligonucleotide Manipulation by Kim, Jinho, Olsen, Timothy R., Zhu, Jing, Hilton, John P., Yang, Kyung-Ae, Pei, Renjun, Stojanovic, Milan N., Lin, Qiao

“…We present a microfluidic approach to integrated isolation of DNA aptamers via systematic evolution of ligands by exponential enrichment (SELEX). The approach…”
Get full text

Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum by Tapia-Alveal, Claudia, Olsen, Timothy R., Worgall, Tilla S.

“…Multiple myeloma (MM) is a neoplasm of plasma cells that secrete patient specific monoclonal immunoglobulins. A recognized problem in MM treatment is the early…”
Get full text

Measurements of aptamer-protein binding kinetics using graphene field-effect transistors by Wang, Xuejun, Hao, Zhuang, Olsen, Timothy R, Zhang, Wenjun, Lin, Qiao

“…Quantifying interactions between biomolecules subject to various environmental conditions is essential for applications such as drug discovery and precision…”
Get more information

A graphene aptasensor for biomarker detection in human serum by Wang, Xuejun, Zhu, Yibo, Olsen, Timothy R., Sun, Na, Zhang, Wenjun, Pei, Renjun, Lin, Qiao

“…This paper presents an affinity graphene nanosensor for detection of biomarkers in undiluted and non-desalted human serum. The affinity nanosensor is a…”
Get full text

Microfluidic isolation of aptamers with affinity towards multiple myeloma monoclonal immunoglobulins by Olsen, Timothy R., Tapia-Alveal, Claudia, Wen, Kechun, Worgall, Tilla S., Stojanovic, Milan N., Lin, Qiao

“…Multiple myeloma (MM) is a bone marrow cancer of resident plasma cells that affects 125,000 patients in the U.S. with about 30,000 new cases per year. Its…”
Get full text

Longitudinal Stretching for Maturation of Vascular Tissues Using Magnetic Forces by Olsen, Timothy R, Casco, Megan, Herbst, Austin, Evans, Grace, Rothermel, Taylor, Pruett, Lauren, Reid, Jared, Barry, Kelly, Jaeggli, Michael P, Simionescu, Dan T, Visconti, Richard P, Alexis, Frank

“…Cellular spheroids were studied to determine their use as "bioinks" in the biofabrication of tissue engineered constructs. Specifically, magnetic forces were…”
Get full text

The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data by Marcus, Daniel S, Olsen, Timothy R, Ramaratnam, Mohana, Buckner, Randy L

“…The Extensible Neuroimaging Archive Toolkit (XNAT) is a software platform designed to facilitate common management and productivity tasks for neuroimaging and…”
Get full text

hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1 A230T Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome by Zhou, Dong, Feng, Hao, Yang, Ying, Huang, Tingting, Qiu, Ping, Zhang, Chengxin, Olsen, Timothy R, Zhang, Jifeng, Chen, Y Eugene, Mizrak, Dogukan, Yang, Bo

“…Loeys-Dietz syndrome (LDS) is an inherited disorder predisposing individuals to thoracic aortic aneurysm and dissection. Currently, there are no medical…”
Get full text

hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1A230T Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome by Zhou, Dong, Feng, Hao, Yang, Ying, Huang, Tingting, Qiu, Ping, Zhang, Chengxin, Olsen, Timothy R., Zhang, Jifeng, Chen, Y. Eugene, Mizrak, Dogukan, Yang, Bo

“…BACKGROUNDLoeys-Dietz syndrome (LDS) is an inherited disorder predisposing individuals to thoracic aortic aneurysm and dissection. Currently, there are no…”
Get full text

Janus magnetic cellular spheroids for vascular tissue engineering by Mattix, Brandon M, Olsen, Timothy R, Casco, Megan, Reese, Laura, Poole, John T, Zhang, Jing, Visconti, Richard P, Simionescu, Agneta, Simionescu, Dan T, Alexis, Frank

“…Abstract Cell aggregates, or spheroids, have been used as building blocks to fabricate scaffold-free tissues that can closely mimic the native…”
Get full text

Biological magnetic cellular spheroids as building blocks for tissue engineering by Mattix, Brandon, Olsen, Timothy R., Gu, Yu, Casco, Megan, Herbst, Austin, Simionescu, Dan T., Visconti, Richard P., Kornev, Konstantin G., Alexis, Frank

“…Magnetic nanoparticles (MNPs), primarily iron oxide nanoparticles, have been incorporated into cellular spheroids to allow for magnetic manipulation into…”
Get full text

Corporate profile: RoosterBio, Inc by Olsen, Timothy R, Rowley, Jon A

“…RoosterBio, Inc. (MD, USA) is a privately held stem cell tools and technology company focused on accelerating the development of a sustainable regenerative…”
Get full text

Accelerated Iron Oxide Nanoparticle Degradation Mediated by Polyester Encapsulation within Cellular Spheroids by Mattix, Brandon, Olsen, Timothy R., Moore, Thomas, Casco, Megan, Simionescu, Dan, Visconti, Richard P., Alexis, Frank

“…Nanomaterials including gold nanoparticles, polymeric nanoparticles, and magnetic iron oxide nanoparticles are utilized in tissue engineering for imaging, drug…”
Get full text

Non-invasive deep tissue imaging of iodine modified poly(caprolactone-co-1-4-oxepan-1,5-dione) using X-ray by Olsen, Timothy R., Davis, Lundy L., Nicolau, Samantha E., Duncan, Caroline C., Whitehead, Daniel C., Van Horn, Brooke A., Alexis, Frank

“…[Display omitted] When biodegradable polyester devices, like sutures and screws, are implanted into the body, it is very challenging to image them in deep…”
Get full text

Oxime functionalization strategy for iodinated poly(epsilon‐caprolactone) X‐ray opaque materials by Nicolau, Samantha E, Davis, Lundy L, Duncan, Caroline C, Olsen, Timothy R, Alexis, Frank, Whitehead, Daniel C, Van Horn, Brooke A

“…Since two of the most common technologies for imaging the human body are X‐ray radiography and computed tomography (CT), researchers are focused on developing…”
Get full text

hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1A230T Variant, and its Therapeutic Implications for Loeys-Dietz Syndrome by Zhou, Dong, Feng, Hao, Yang, Ying, Huang, Tingting, Qiu, Ping, Zhang, Chengxin, Olsen, Timothy R., Zhang, Jifeng, Chen, Y. Eugene, Mizrak, Dogukan, Yang, Bo

Get full text

Abstract 1170: Scalable co-sequencing of RNA and DNA from individual nuclei by Olsen, Timothy R., Talla, Pranay, Furnari, Julia, Zha, Shan, Canoll, Peter, Bruce, Jeffrey, Sims, Peter

“…A scalable co-assay for single cell mRNA and gDNA sequencing could potentially harmonize the identification of rare cell populations and cell states with…”
Get full text

An aptameric graphene nanosensor for analyte detection in serum by Xuejun Wang, Yibo Zhu, Olsen, Timothy R., Na Sun, Wenjun Zhang, Renjun Pei, Qiao Lin

“…We present an aptameric graphene field-effect transistor (GFET) nanosensor for sensitive and label-free detection of biomarkers in serum. The graphene…”
Get full text