Search Results - "Olsen, Johan G"

Protein stability, flexibility and function by Teilum, Kaare, Olsen, Johan G., Kragelund, Birthe B.

“…Proteins rely on flexibility to respond to environmental changes, ligand binding and chemical modifications. Potentially, a perturbation that changes the…”
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Interactions by Disorder - A Matter of Context by Bugge, Katrine, Brakti, Inna, Fernandes, Catarina B, Dreier, Jesper E, Lundsgaard, Jeppe E, Olsen, Johan G, Skriver, Karen, Kragelund, Birthe B

“…Living organisms depend on timely and organized interactions between proteins linked in interactomes of high complexity. The recent increased precision by…”
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A combined computational and structural model of the full-length human prolactin receptor by Bugge, Katrine, Papaleo, Elena, Haxholm, Gitte W., Hopper, Jonathan T. S., Robinson, Carol V., Olsen, Johan G., Lindorff-Larsen, Kresten, Kragelund, Birthe B.

“…The prolactin receptor is an archetype member of the class I cytokine receptor family, comprising receptors with fundamental functions in biology as well as…”
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The WSXWS Motif in Cytokine Receptors Is a Molecular Switch Involved in Receptor Activation: Insight from Structures of the Prolactin Receptor by Dagil, Robert, Knudsen, Maiken J., Olsen, Johan G., O'Shea, Charlotte, Franzmann, Magnus, Goffin, Vincent, Teilum, Kaare, Breinholt, Jens, Kragelund, Birthe B.

“…The prolactin receptor (PRLR) is activated by binding of prolactin in a 2:1 complex, but the activation mechanism is poorly understood. PRLR has a conserved…”
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Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes by Haxholm, Gitte W, Nikolajsen, Louise F, Olsen, Johan G, Fredsted, Jacob, Larsen, Flemming H, Goffin, Vincent, Pedersen, Stine F, Brooks, Andrew J, Waters, Michael J, Kragelund, Birthe B

“…Class 1 cytokine receptors regulate essential biological processes through complex intracellular signalling networks. However, the structural platform for…”
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Structure of Radical-Induced Cell Death1 Hub Domain Reveals a Common αα-Scaffold for Disorder in Transcriptional Networks by Bugge, Katrine, Staby, Lasse, Kemplen, Katherine R., O'Shea, Charlotte, Bendsen, Sidsel K., Jensen, Mikael K., Olsen, Johan G., Skriver, Karen, Kragelund, Birthe B.

“…Communication within cells relies on a few protein nodes called hubs, which organize vast interactomes with many partners. Frequently, hub proteins are…”
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Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats by Olsen, Johan G, Kragelund, Birthe B

“…Abstract For decades, a spectacular structural motif has been the focus of research in two families of animal membrane proteins: the hematopoietic cytokine…”
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Dynamic Na+/H+ exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation by Sjøgaard-Frich, Lise M, Prestel, Andreas, Pedersen, Emilie S, Severin, Marc, Kristensen, Kristian Kølby, Olsen, Johan G, Kragelund, Birthe B, Pedersen, Stine Falsig

“…Calmodulin (CaM) engages in Ca 2+ -dependent interactions with numerous proteins, including a still incompletely understood physical and functional interaction…”
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Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli by Hamborg, Louise, Granata, Daniele, Olsen, Johan G., Roche, Jennifer Virginia, Pedersen, Lasse Ebdrup, Nielsen, Alex Toftgaard, Lindorff-Larsen, Kresten, Teilum, Kaare

“…Most single point mutations destabilize folded proteins. Mutations that stabilize a protein typically only have a small effect and multiple mutations are often…”
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Globular and disordered-the non-identical twins in protein-protein interactions by Teilum, Kaare, Olsen, Johan G, Kragelund, Birthe B

“…In biology proteins from different structural classes interact across and within classes in ways that are optimized to achieve balanced functional outputs. The…”
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Behaviour of intrinsically disordered proteins in protein–protein complexes with an emphasis on fuzziness by Olsen, Johan G., Teilum, Kaare, Kragelund, Birthe B.

“…Intrinsically disordered proteins (IDPs) do not, by themselves, fold into a compact globular structure. They are extremely dynamic and flexible, and are…”
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Comment on “Intrinsic protein disorder uncouples affinity from binding specificity” by Teilum, Kaare, Olsen, Johan G., Kragelund, Birthe B.

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Functional aspects of protein flexibility by Teilum, Kaare, Olsen, Johan G, Kragelund, Birthe B

“…Proteins are dynamic entities, and they possess an inherent flexibility that allows them to function through molecular interactions within the cell, among…”
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The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery by Simonsen, Signe, Søgaard, Caroline K., Olsen, Johan G., Otterlei, Marit, Kragelund, Birthe B.

“…DNA replication is a tightly coordinated event carried out by a multiprotein replication complex. An essential factor in the bacterial replication complex is…”
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Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins by Pesce, Francesco, Newcombe, Estella A., Seiffert, Pernille, Tranchant, Emil E., Olsen, Johan G., Grace, Christy R., Kragelund, Birthe B., Lindorff-Larsen, Kresten

“…Diffusion measurements by pulsed-field gradient NMR and fluorescence correlation spectroscopy can be used to probe the hydrodynamic radius of proteins, which…”
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Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of α-1 antitrypsin by Meinert Niclasen, Louise, Olsen, Johan G, Dagil, Robert, Qing, Zhang, Sørensen, Ole E, Kragelund, Birthe B

“…The Streptococcus pyogenes cysteine protease SpeB (streptococcal pyrogenic exotoxin B) is important for the invasive potential of the bacteria, but its…”
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Barley aldose reductase: Structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family by Olsen, Johan G., Pedersen, Lise, Christensen, Christina L., Olsen, Ole, Henriksen, Anette

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Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs by Olsen, Johan G, Prestel, Andreas, Kassem, Noah, Broendum, Sebastian S, Shamim, Hossain Mohammad, Simonsen, Signe, Grysbæk, Martin, Mortensen, Josefine, Rytkjær, Louise Lund, Haxholm, Gitte W, Marabini, Riccardo, Holmberg, Christian, Carr, Antony M, Crehuet, Ramon, Nielsen, Olaf, Kragelund, Birthe B

“…Abstract DNA regulation, replication and repair are processes fundamental to all known organisms and the sliding clamp proliferating cell nuclear antigen…”
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Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone Template by Johansson, Kristoffer E., Johansen, Nicolai Tidemand, Christensen, Signe, Horowitz, Scott, Bardwell, James C.A., Olsen, Johan G., Willemoës, Martin, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, Jesper, Hamelryck, Thomas, Winther, Jakob R.

“…Despite the development of powerful computational tools, the full-sequence design of proteins still remains a challenging task. To investigate the limits and…”
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Fatty acid synthesis by von Wettstein‐Knowles, Penny, Olsen, Johan G., McGuire, Kirsten A., Henriksen, Anette

“…β‐Ketoacyl‐acyl carrier protein (ACP) synthase enzymes join short carbon units to construct fatty acyl chains by a three‐step Claisen condensation reaction…”
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