Search Results - "Olsen, Abby L"

Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity by Olsen, Abby L., Feany, Mel B.

“…Idiopathic Parkinson's disease is the second most common neurodegenerative disease and is estimated to be approximately 30% heritable. Genome wide association…”
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α-synuclein impairs autophagosome maturation through abnormal actin stabilization by Sarkar, Souvarish, Olsen, Abby L, Sygnecka, Katja, Lohr, Kelly M, Feany, Mel B

“…Vesicular trafficking defects, particularly those in the autophagolysosomal system, have been strongly implicated in the pathogenesis of Parkinson's disease…”
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Immunotherapy in progressive supranuclear palsy by Vaswani, Pavan A., Olsen, Abby L.

“…Progressive supranuclear palsy (PSP) is a progressive adult-onset neurodegenerative disease. Abnormally, phosphorylated forms of the microtubule-associated…”
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Hepatic stellate cells require a stiff environment for myofibroblastic differentiation by Olsen, Abby L, Bloomer, Steven A, Chan, Erick P, Gaça, Marianna D A, Georges, Penelope C, Sackey, Bridget, Uemura, Masayuki, Janmey, Paul A, Wells, Rebecca G

“…The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver fibrosis and is part of the final common pathway to cirrhosis…”
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Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells by Sarkar, Souvarish, Dammer, Eric B, Malovic, Emir, Olsen, Abby L, Raza, Syed Ali, Gao, Tianwen, Xiao, Hailian, Oliver, Danielle L, Duong, Duc, Joers, Valerie, Seyfried, Nicholas, Huang, Meixiang, Kukar, Thomas, Tansey, Malú G, Kanthasamy, Anumantha G, Rangaraju, Srikant

“…Alpha-synuclein (αSyn ) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation and…”
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Downregulation of the tyrosine degradation pathway extends Drosophila lifespan by Parkhitko, Andrey A, Ramesh, Divya, Wang, Lin, Leshchiner, Dmitry, Filine, Elizabeth, Binari, Richard, Olsen, Abby L, Asara, John M, Cracan, Valentin, Rabinowitz, Joshua D, Brockmann, Axel, Perrimon, Norbert

“…Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the…”
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Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy by Sackey-Aboagye, Bridget, Olsen, Abby L, Mukherjee, Sarmistha M, Ventriglia, Alexander, Yokosaki, Yasuyuki, Greenbaum, Linda E, Lee, Gi Yun, Naga, Hani, Wells, Rebecca G

“…Liver sinusoidal endothelial cells (LSECs) are the main endothelial cells in the liver and are important for maintaining liver homeostasis as well as…”
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The case of an 85‐year‐old woman with subacute onset of bilateral chorea by Nakatsuka, Nathan J., Nakhate, Vihang, Harrison, Daniel S., Galetta, Kristin M., Olsen, Abby L.

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Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo by Sarkar, Souvarish, Bardai, Farah, Olsen, Abby L, Lohr, Kelly M, Zhang, Ying-Yi, Feany, Mel B

“…Mutations in LRRK2 are the most common cause of familial Parkinson's disease and typically cause disease in the context of abnormal aggregation and deposition…”
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Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy by Sarkar, Souvarish, Murphy, Michael A., Dammer, Eric B., Olsen, Abby L., Rangaraju, Srikant, Fraenkel, Ernest, Feany, Mel B.

“…The synaptic protein α-synuclein is linked through genetics and neuropathology to the pathogenesis of Parkinson’s disease and related disorders. However, the…”
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Designer blood: creating hematopoietic lineages from embryonic stem cells by Olsen, Abby L., Stachura, David L., Weiss, Mitchell J.

“…Embryonic stem (ES) cells exhibit the remarkable capacity to become virtually any differentiated tissue upon appropriate manipulation in culture, a property…”
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PARP Inhibitors and Parkinson’s Disease by Olsen, Abby L, Feany, Mel B

“…A recent study implicates the enzyme poly(adenosine 5′-diphosphate-ribose) polymerase 1 (PARP1) as a mediator of neuronal cell death in Parkinson’s disease…”
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Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo by Olsen, Abby L., Feany, Mel B.

“…α‐Synucleinopathies are neurodegenerative diseases that are characterized pathologically by α‐synuclein inclusions in neurons and glia. The pathologic…”
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Cerebral perfusion in stroke-like migraine attacks after radiation therapy syndrome by Olsen, Abby L, Miller, Julie J, Bhattacharyya, Shamik, Voinescu, P Emanuela, Klein, Joshua P

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Nicotine‐Mediated Rescue of α‐Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila by Olsen, Abby L., Clemens, Sabrina G., Feany, Mel B.

“…ABSTRACT Background Parkinson's disease (PD) is characterized by α‐synuclein aggregation and loss of dopamine neurons. Risk of PD arises due to a combination…”
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The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix by Klingberg, Franco, Chau, Grace, Walraven, Marielle, Boo, Stellar, Koehler, Anne, Chow, Melissa L, Olsen, Abby L, Im, Michelle, Lodyga, Monika, Wells, Rebecca G, White, Eric S, Hinz, Boris

“…Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate disordered and stiff extracellular matrix (ECM) leading…”
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Isolation of rat portal fibroblasts by in situ liver perfusion by Wen, Jessica W, Olsen, Abby L, Perepelyuk, Maryna, Wells, Rebecca G

“…Liver fibrosis is defined by the excessive deposition of extracellular matrix by activated myofibroblasts. There are multiple precursors of hepatic…”
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Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment by Hagemann, Tracy L, Powers, Berit, Lin, Ni-Hsuan, Mohamed, Ahmed F, Dague, Katerina L, Hannah, Seth C, Bachmann, Gemma, Mazur, Curt, Rigo, Frank, Olsen, Abby L, Feany, Mel B, Perng, Ming-Der, Berman, Robert F, Messing, Albee

“…Alexander disease (AxD) is a devastating leukodystrophy caused by gain-of-function mutations in , and the only available treatments are supportive. Recent…”
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Discovering New Benefits From Old Drugs With Big Data-Promise for Parkinson Disease by Olsen, Abby L, Riise, Trond, Scherzer, Clemens R

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Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology by Argent, Liam, Winter, Friederike, Prickett, Imogen, Carrasquero-Ordaz, Maria, Olsen, Abby L., Kramer, Holger, Lancaster, Eric, Becker, Esther B.E.

“…Contactin-associated protein-like 2 (Caspr2) is a neurexin-like protein that has been associated with numerous neurological conditions. However, the specific…”
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