Search Results - "Olonisakin, Tolani"
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A checklist is associated with increased quality of reporting preclinical biomedical research: A systematic review
Published in PloS one (13-09-2017)“…Irreproducibility of preclinical biomedical research has gained recent attention. It is suggested that requiring authors to complete a checklist at the time of…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes
Published in Clinical infectious diseases (03-05-2022)“…Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (vRNA) is detected in the bloodstream of some patients with…”
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Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness
Published in American journal of respiratory and critical care medicine (15-07-2020)“…Complement is crucial for host defense but may also drive dysregulated inflammation. There is limited understanding of alternative complement function, which…”
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Fighting Bacterial Pathogens in the Lung: Platelets to the Rescue?
Published in American journal of respiratory cell and molecular biology (01-03-2018)“…[...]activated platelets can tether recruited neutrophils via P-selectin, leading to neutrophil integrin activation and induction of a neutrophilic…”
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Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation
Published in The Journal of clinical investigation (01-01-2021)“…Macrophages are main effectors of heme metabolism, increasing transiently in the liver during heightened disposal of damaged or senescent RBCs (sRBCs)…”
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In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection
Published in The Journal of infectious diseases (25-07-2024)“…Klebsiella pneumoniae carbapenemase-producing K pneumoniae (KPC-Kp) bloodstream infections are associated with high mortality. We studied clinical bloodstream…”
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Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection
Published in mBio (06-04-2021)“…Interleukin-36γ (IL-36γ), a member of the IL-1 cytokine superfamily, amplifies lung inflammation and impairs host defense during acute pulmonary infection. To…”
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Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit
Published in Clinical cancer research (16-02-2023)“…Neoadjuvant targeted therapy provides a brief, preoperative window of opportunity that can be exploited to individualize cancer care based on treatment…”
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Fractional Exhaled Nitric Oxide as a Marker of Mucosal Inflammation in Chronic Rhinosinusitis
Published in American journal of rhinology & allergy (01-07-2022)“…Background Fractional exhaled nitric oxide (FeNO) is a cost-effective, noninvasive point-of-care test that has proven valuable in identifying patients with…”
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CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis
Published in The Journal of infectious diseases (15-12-2016)“…Klebsiella pneumoniae remains an important cause of intrapulmonary infection and invasive disease worldwide. K. pneumoniae can evade serum killing and…”
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Local cytokine levels associate with SNOT‐22 and UPSIT scores in chronic rhinosinusitis
Published in International forum of allergy & rhinology (01-01-2024)“…Key points Elevated IL‐5, IL‐13, IL‐33, and CCL2 correlate with lower UPSIT scores in CRS and AERD patients. Elevated IL‐5, IL‐13, TNF‐α, CCL2, and CXCL‐8…”
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Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury
Published in Blood advances (12-02-2019)“…Thrombocytopenia is associated with worse outcomes in patients with acute respiratory distress syndrome, which is most commonly caused by infection and marked…”
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Signal‐transduction pathways in hemolysis‐associated right‐ventricular failure (1097.12)
Published in The FASEB journal (01-04-2014)“…The pulmonary arterial pressure at which the right ventricle fails in patients with sickle‐cell disease occurs at markedly lower pressures than in pulmonary…”
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Journal Article -
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In vivo evolution of a Klebsiella pneumoniae capsule defect with wcaJ mutation promotes complement-mediated opsono-phagocytosis during recurrent infection
Published in The Journal of infectious diseases (25-01-2024)“…Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) bloodstream infections are associated with high mortality. We studied clinical bloodstream…”
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Journal Article -
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Stressed Erythrophagocytosis as a Modifier of the Innate Immune Response to Klebsiella pneumoniae
Published 01-01-2020“…Macrophages are main effectors of heme metabolism, increasing transiently in the liver during heightened disposal of damaged or senescent red cells (sRBC)…”
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Dissertation -
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Abstract 4338: Response to neoadjuvant targeted therapy in operable head and neck cancer confers survival benefit
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Purpose: Neoadjuvant targeted therapy provides a brief, preoperative ‘window of opportunity’ that can be exploited to individualize cancer care based…”
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Journal Article -
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Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection
Published in Mucosal immunology (01-07-2015)“…Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promote tissue…”
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Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis
Published in JCI insight (08-02-2018)“…Acute lung injury is characterized by excessive extracellular matrix proteolysis and neutrophilic inflammation. A major risk factor for lung injury is…”
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Journal Article