Search Results - "Olofsson, Frida J"
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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer
Published in Proceedings of the National Academy of Sciences - PNAS (06-04-2010)“…RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein…”
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Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice
Published in The Journal of clinical investigation (01-02-2011)“…RHO family proteins are important for the function of inflammatory cells. They are modified with a 20-carbon geranylgeranyl lipid in a process catalyzed by…”
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Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease
Published in Leukemia (01-01-2011)“…Letter to the Editor…”
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Journal Article