Search Results - "Olney, John W"

Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain by BRAMBRINK, Ansgar M, EVERS, Alex S, AVIDAN, Michael S, FARBER, Nuri B, SMITH, Derek J, XUEZHAO ZHANG, DISSEN, Gregory A, CREELEY, Catherine E, OLNEY, John W

“…Brief isoflurane anesthesia induces neuroapoptosis in the developing rodent brain, but susceptibility of non-human primates to the apoptogenic action of…”
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Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain by Creeley, Catherine E, Dikranian, Krikor T, Dissen, Gregory A, Back, Stephen A, Olney, John W, Brambrink, Ansgar M

“…BACKGROUND:The authors have previously shown that exposure of the neonatal nonhuman primate (NHP) brain to isoflurane for 5 h causes widespread acute apoptotic…”
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Ketamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain by BRAMBRINK, Ansgar M, EVERS, Alex S, AVIDAN, Michael S, FARBER, Nuri B, SMITH, Derek J, MARTIN, Lauren D, DISSEN, Gregory A, CREELEY, Catherine E, OLNEY, John W

“…Exposure of rhesus macaque fetuses for 24 h or neonates for 9 h to ketamine anesthesia causes neuroapoptosis in the developing brain. The current study…”
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Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain by Brambrink, Ansgar M., Back, Stephen A., Riddle, Art, Gong, Xi, Moravec, Matthew D., Dissen, Gregory A., Creeley, Catherine E., Dikranian, Krikor T., Olney, John W.

“…Objective: Previously we reported that exposure of 6‐day‐old (P6) rhesus macaques to isoflurane for 5 hours triggers a robust neuroapoptosis response in…”
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Subanesthetic Doses of Propofol Induce Neuroapoptosis in the Infant Mouse Brain by Cattano, Davide, Young, Chainllie, Straiko, Megan M.W., Olney, John W.

“…Drugs that block N-methyl-d-aspartate glutamate receptors or that promote γ-aminobutyric acid type A inhibition trigger neuroapoptosis in the developing rodent…”
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Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain by Young, Chainllie, Jevtovic‐Todorovic, Vesna, Qin, Yue‐Qin, Tenkova, Tatyana, Wang, Haihui, Labruyere, Joann, Olney, John W

“…Recently, it was reported that anesthetizing infant rats for 6 h with a combination of anesthetic drugs (midazolam, nitrous oxide, isoflurane) caused…”
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Alcohol-induced neuroapoptosis in the fetal macaque brain by Farber, Nuri B, Creeley, Catherine E, Olney, John W

“…Abstract The ability of brief exposure to alcohol to cause widespread neuroapoptosis in the developing rodent brain and subsequent long-term neurocognitive…”
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Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits by Jevtovic-Todorovic, Vesna, Hartman, Richard E, Izumi, Yukitoshi, Benshoff, Nicholas D, Dikranian, Krikor, Zorumski, Charles F, Olney, John W, Wozniak, David F

“…Recently it was demonstrated that exposure of the developing brain during the period of synaptogenesis to drugs that block NMDA glutamate receptors or drugs…”
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Lithium Protects against Anesthesia-induced Developmental Neuroapoptosis by STRAIKO, Megan M. W, YOUNG, Chainllie, CATTANO, Davide, CREELEY, Catherine E, HAIHUI WANG, SMITH, Derek J, JOHNSON, Stephen A, LI, Erin S, OLNEY, John W

“…Ethanol and anesthetic drugs trigger neuroapoptosis in the developing mouse brain. Recently, it was found that ethanol-induced neuroapoptosis is preceded by…”
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Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration by Young, Chainllie, Olney, John W.

“…Exposure of infant rats or mice to ethanol on a single occasion during the period of rapid synaptogenesis can cause extensive apoptotic neurodegeneration…”
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Isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice by Johnson, Stephen A, Young, Chainllie, Olney, John W

“…Drugs that suppress neuronal activity, including general anesthetics used in pediatric and obstetric medicine, trigger neuroapoptosis in the developing rodent…”
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Focus on apoptosis to decipher how alcohol and many other drugs disrupt brain development by Olney, John W

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Antiepileptic Drugs and Apoptotic Neurodegeneration in the Developing Brain by Bittigau, Petra, Sifringer, Marco, Genz, Kerstin, Reith, Ellen, Pospischil, Dana, Govindarajalu, Suresh, Dzietko, Mark, Pesditschek, Stefanie, Mai, Ingrid, Dikranian, Krikor, Olney, John W., Ikonomidou, Chrysanthy

“…Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure…”
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Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults by Wozniak, David F., Hartman, Richard E., Boyle, Maureen P., Vogt, Sherri K., Brooks, Ashley R., Tenkova, Tatyana, Young, Chainllie, Olney, John W., Muglia, Louis J.

“…Administration of ethanol to rodents during the synaptogenesis period induces extensive apoptotic neurodegeneration in the developing brain. This neurotoxicity…”
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Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain by Cattano, Davide, Williamson, Peter, Fukui, Kimiko, Avidan, Michael, Evers, Alex S., Olney, John W., Young, Chainllie

“…Purpose: Drugs that suppress neuronal activity, including all general anesthetics that have been tested thus far (ketamine, midazolam, isoflurane, propofol,…”
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Low Doses of Memantine Disrupt Memory in Adult Rats by Creeley, Catherine, Wozniak, David F, Labruyere, Joanne, Taylor, George T, Olney, John W

“…Memantine, a drug recently approved for treatment of Alzheimer's disease, has been characterized as a unique NMDA antagonist that confers protection against…”
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Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain by Ikonomidou, Chrysanthy, Bosch, Friederike, Miksa, Michael, Bittigau, Petra, Vöckler, Jessica, Dikranian, Krikor, Tenkova, Tanya I., Stefovska, Vanya, Turski, Lechoslaw, Olney, John W.

“…Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will…”
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Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome by Ikonomidou, Chrysanthy, Bittigau, Petra, Ishimaru, Masahiko J., Wozniak, David F., Koch, Christian, Genz, Kerstin, Price, Madelon T., Stefovska, Vanya, Hörster, Friederike, Tenkova, Tanya, Dikranian, Krikor, Olney, John W.

“…The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade…”
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Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis by Shacka, John J, Klocke, Barbara J, Young, Chainllie, Shibata, Masahiro, Olney, John W, Uchiyama, Yasuo, Saftig, Paul, Roth, Kevin A

“…Neuronal ceroid lipofuscinosces/Batten disease (NCL) is a devastating group of neurodegenerative diseases caused by genetic disruptions in lysosomal function…”
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Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain by Creeley, Catherine E, Dikranian, Krikor T, Johnson, Stephen A, Farber, Nuri B, Olney, John W

“…In utero exposure of the fetal non-human primate (NHP) brain to alcohol on a single occasion during early or late third-trimester gestation triggers widespread…”
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