Search Results - "Olnes, Matthew"

Global analyses of human immune variation reveal baseline predictors of postvaccination responses by Tsang, John S, Schwartzberg, Pamela L, Kotliarov, Yuri, Biancotto, Angelique, Xie, Zhi, Germain, Ronald N, Wang, Ena, Olnes, Matthew J, Narayanan, Manikandan, Golding, Hana, Moir, Susan, Dickler, Howard B, Perl, Shira, Cheung, Foo

“…A major goal of systems biology is the development of models that accurately predict responses to perturbation. Constructing such models requires the…”
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Recent advances in immune therapies for gastric cancer by Olnes, Matthew J., Martinson, Holly A.

“…Gastric cancer (GC) is an aggressive malignancy that is the third leading cause of cancer mortality worldwide. Localized GC can be cured with surgery, but most…”
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Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug by Desmond, Ronan, Townsley, Danielle M., Dumitriu, Bogdan, Olnes, Matthew J., Scheinberg, Phillip, Bevans, Margaret, Parikh, Ankur R., Broder, Kinneret, Calvo, Katherine R., Wu, Colin O., Young, Neal S., Dunbar, Cynthia E.

“…About a quarter of patients with severe aplastic anemia remain pancytopenic despite immunosuppressive therapy. We have previously demonstrated that eltrombopag…”
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Immune Therapies for Hematologic Malignancies by Olnes, Matthew J

“…The era of immunotherapy for hematologic malignancies began with the first allogeneic hematopoietic stem cell transplant (HSCT) study published by E [...]…”
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Thrombopoietin receptor agonists for marrow failure: A concise clinical review by Kapoor, Sargam, Champion, Grace, Olnes, Matthew J.

“…Bone marrow failure is characterized by a disruption of hematopoietic stem cell (HSC) homeostasis and function, which causes decreased blood counts. Germline…”
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Eltrombopag and Improved Hematopoiesis in Refractory Aplastic Anemia by Olnes, Matthew J, Scheinberg, Phillip, Calvo, Katherine R, Desmond, Ronan, Tang, Yong, Dumitriu, Bogdan, Parikh, Ankur R, Soto, Susan, Biancotto, Angelique, Feng, Xingmin, Lozier, Jay, Wu, Colin O, Young, Neal S, Dunbar, Cynthia E

“…A phase 2 study showed a 44% response rate with eltrombopag, an oral thrombopoietin mimetic, among 25 patients with refractory aplastic anemia. Severe aplastic…”
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Baseline levels and temporal stability of 27 multiplexed serum cytokine concentrations in healthy subjects by Biancotto, Angelique, Wank, Abigail, Perl, Shira, Cook, Wendell, Olnes, Matthew J, Dagur, Pradeep K, Fuchs, J Christopher, Langweiler, Marc, Wang, Ena, McCoy, J Philip

“…Cytokines are humoral molecules that elicit regulatory function in immunologic pathways. The level and type of cytokine production has become critical in…”
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Effects of Systemically Administered Hydrocortisone on the Human Immunome by Olnes, Matthew J., Kotliarov, Yuri, Biancotto, Angélique, Cheung, Foo, Chen, Jinguo, Shi, Rongye, Zhou, Huizhi, Wang, Ena, Tsang, John S., Nussenblatt, Robert

“…Corticosteroids have been used for decades to modulate inflammation therapeutically, yet there is a paucity of data on their effects in humans. We examined the…”
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Immune Therapies for Myelodysplastic Syndromes and Acute Myeloid Leukemia by Kapoor, Sargam, Champion, Grace, Basu, Aparna, Mariampillai, Anu, Olnes, Matthew J.

“…Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are hematologic malignancies arising from the bone marrow. Despite recent advances in treating…”
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Gastric cancer in Alaska Native people: A cancer health disparity by Martinson, Holly A, Shelby, Nancy J, Alberts, Steven R, Olnes, Matthew J

“…To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native (AN) people. A retrospective analysis of…”
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Eltrombopag monotherapy can improve hematopoiesis in patients with low to intermediate risk-1 myelodysplastic syndrome by Vicente, Alana, Patel, Bhavisha A, Gutierrez-Rodrigues, Fernanda, Groarke, Emma, Giudice, Valentina, Lotter, Jennifer, Feng, Xingmin, Kajigaya, Sachiko, Weinstein, Barbara, Barranta, Evette, Olnes, Matthew J, Parikh, Ankur R, Albitar, Maher, Wu, Colin O, Shalhoub, Ruba, Calvo, Katherine R, Townsley, Danielle M, Scheinberg, Phillip, Dunbar, Cynthia E, Young, Neal S, Winkler, Thomas

“…Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders characterized by cytopenia and a propensity to develop acute myeloid leukemia (AML)…”
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Eltrombopag monotherapy can improve hematopoiesis in patients with low to intermediate risk-1 myelodysplastic syndrome by Vicente, Alana, Patel, Bhavisha A, Gutierrez-Rodrigues, Fernanda, Groarke, Emma, Giudice, Valentina, Lotter, Jennifer, Feng, Xingmin, Kajigaya, Sachiko, Weinstein, Barbara, Barranta, Evette, Olnes, Matthew J, Parikh, Ankur R, Albitar, Maher, Wu, Colin O, Shalhoub, Ruba, Calvo, Katherine R, Townsley, Danielle M, Scheinberg, Phillip, Dunbar, Cynthia E, Young, Neal S, Winkler, Thomas

“…Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders characterized by cytopenia and a propensity to develop acute myeloid leukemia (AML)…”
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Ultra-low Dose Interleukin-2 Promotes Immune-modulating Function of Regulatory T Cells and Natural Killer Cells in Healthy Volunteers by Ito, Sawa, Bollard, Catherine M, Carlsten, Mattias, Melenhorst, Jan Joseph, Biancotto, Angélique, Wang, Ena, Chen, Jinguo, Kotliarov, Yuri, Cheung, Foo, Xie, Zhi, Marincola, Francesco, Tanimoto, Kazushi, Battiwalla, Minoo, Olnes, Matthew J, Perl, Shira, Schum, Paula, Hughes, Thomas E, Keyvanfar, Keyvan, Hensel, Nancy, Muranski, Pawel, Young, Neal S, Barrett, A John

“…Low-dose interleukin-2 (IL-2) expands regulatory T cells (Tregs) and natural killer (NK) cells after stem cell transplantation (SCT) and may reduce…”
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Molecular Classification of Gastric Cancer among Alaska Native People by Martinson, Holly A, Mallari, Dominic, Richter, Christine, Wu, Tsung-Teh, Tiesinga, James, Alberts, Steven R, Olnes, Matthew J

“…Gastric cancer is an aggressive and heterogeneous malignancy that often varies in presentation and disease among racial and ethnic groups. The Alaska Native…”
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Alemtuzumab Treatment of Intermediate-1 Myelodysplasia Patients Is Associated With Sustained Improvement in Blood Counts and Cytogenetic Remissions by SLOAND, Elaine M, OLNES, Matthew J, YOUNG, Neal S, SHENOY, Aarthie, WEINSTEIN, Barbara, BOSS, Carol, LOELIGER, Kelsey, WU, Colin O, MORE, Kenneth, BARRETT, A. John, SCHEINBERG, Phillip

“…Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and progression to leukemia. Clinical and experimental evidence suggests an…”
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Targeting Immune Dysregulation in Myelodysplastic Syndromes by Olnes, Matthew J, Sloand, Elaine M

“…Myelodysplastic syndromes (MDS) are a heterogeneous group of bone marrow disorders characterized by ineffective hematopoiesis and a tendency to develop…”
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Acute and persistent responses after H5N1 vaccination in humans by Apps, Richard, Biancotto, Angélique, Candia, Julián, Kotliarov, Yuri, Perl, Shira, Cheung, Foo, Farmer, Rohit, Mulè, Matthew P., Rachmaninoff, Nicholas, Chen, Jinguo, Martins, Andrew J., Shi, Rongye, Zhou, Huizhi, Bansal, Neha, Schum, Paula, Olnes, Matthew J., Milanez-Almeida, Pedro, Han, Kyu Lee, Sellers, Brian, Cortese, Mario, Hagan, Thomas, Rouphael, Nadine, Pulendran, Bali, King, Lisa, Manischewitz, Jody, Khurana, Surender, Golding, Hana, van der Most, Robbert G., Dickler, Howard B., Germain, Ronald N., Schwartzberg, Pamela L., Tsang, John S.

“…To gain insight into how an adjuvant impacts vaccination responses, we use systems immunology to study human H5N1 influenza vaccination with or without the…”
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A review and update on cholangiocarcinoma by Olnes, Matthew J, Erlich, Rodrigo

“…Cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium that was first described by Durand-Fardel in 1840. Today, it continues to defy…”
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FISHing for aneuploidy in HSCT donors by Olnes, Matthew J.

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Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia by Zhao, Xin, Feng, Xingmin, Wu, Zhijie, Winkler, Thomas, Desmond, Ronan, Olnes, Matthew, Dumitriu, Bogdan, Townsley, Danielle M., Dunbar, Cynthia E., Young, Neal S.

“…Although hematopoietic growth factors are found at high levels in aplastic anemia (AA) patients, little is known about their dynamic change over time after…”
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