Search Results - "Olmstead, M. C."

Alcohol intoxication alters cognitive skills mediated by frontal and temporal brain regions by Magrys, S.A., Olmstead, M.C.

“…•Moderate and high doses of alcohol impair frontally- and temporally-mediated cognitive skills.•Alcohol intoxication impairs sustained attention in males but…”
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Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor–G protein coupling and Gβγ signaling by Wang, H.-Y., Friedman, E., Olmstead, M.C., Burns, L.H.

“…Opiates produce analgesia by activating μ opioid receptor-linked inhibitory G protein signaling cascades and related ion channel interactions that suppress…”
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Neuroendocrinological responses to alcohol intoxication in healthy males: Relationship with impulsivity, drinking behavior, and subjective effects by Magrys, S. A., Olmstead, M. C., Wynne-Edwards, K. E., Balodis, I. M.

“…Ambiguous biochemical and subjective responses to alcohol may relate to preexisting individual differences in alcohol expectations, experience, or impulsivity…”
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Integrated contributions of basal forebrain and thalamus to neocortical activation elicited by pedunculopontine tegmental stimulation in urethane-anesthetized rats by Dringenberg, H.C, Olmstead, M.C

“…Efferents from the pedunculopontine tegmentum (PPTg) exert widespread control over neocortical electrocorticographic (ECoG) activity and aid in maintaining…”
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Acute stress increases voluntary consumption of alcohol in undergraduates by Magrys, S A, Olmstead, M C

“…The primary aim of this study was to assess whether an acute stressor directly increases alcohol intake among undergraduates. A secondary aim was to examine…”
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Cocaine-seeking by rats: regulation, reinforcement and activation by OLMSTEAD, M. C, PARKINSON, J. A, MILES, F. J, EVERITT, B. J, DICKINSON, A

“…In animal models of drug self-administration, response rates often decrease with dose suggesting that a regulative process may mask the reinforcing effects of…”
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The Development of a Conditioned Place Preference to Morphine: Effects of Microinjections Into Various CNS Sites by Olmstead, Mary C, Franklin, Keith B. J

“…Experiment 1 examined whether microinjections of morphine (1 μg in 0.5 μl over 1 min × 2 pairings) into 13 different CNS sites produced a conditioned place…”
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Pedunculopontine Tegmental Nucleus Lesions Impair Stimulus-Reward Learning in Autoshaping and Conditioned Reinforcement Paradigms by Inglis, W. L, Olmstead, M. C, Robbins, T. W

“…The role of the pedunculopontine tegmental nucleus (PPTg) in stimulus-reward learning was assessed by testing the effects of PPTg lesions on performance in…”
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Prolonged morphine treatment alters δ opioid receptor post‐internalization trafficking by Ong, E W, Xue, L, Olmstead, M C, Cahill, C M

“…Background and Purpose The δ opioid receptor (DOP receptor) undergoes internalization both constitutively and in response to agonists. Previous work has shown…”
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Chronic prenatal ethanol exposure impairs conditioned responding and enhances GABA release in the hippocampus of the adult guinea pig by Hayward, M L, Martin, A E, Brien, J F, Dringenberg, H C, Olmstead, M C, Reynolds, J N

“…In this study, we assessed the effects of chronic prenatal ethanol exposure (CPEE) on spatial navigation in the water maze, conditioned responding using…”
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The Development of a Conditioned Place Preference to Morphine: Effects of Lesions of Various CNS Sites by Olmstead, Mary C, Franklin, Keith B. J

“…This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg × 3 pairings) by testing…”
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Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test by Olmstead, M C, Franklin, K B

“…The development of a conditioned place preference to morphine (2 mg/kg; three pairings) and the analgesic effect of morphine (0, 4 or 8 mg/kg) in the formalin…”
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Lesions of the pedunculopontine tegmental nucleus block drug-induced reinforcement but not amphetamine-induced locomotion by Olmstead, M C, Franklin, K B

“…It has been proposed that the positive reinforcing and motor stimulating effects of drugs involve the activation of a common neural substrate. Reinforcing…”
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Differential effects of ventral striatal lesions on the conditioned place preference induced by morphine or amphetamine by Olmstead, M.C., Franklin, K.B.J.

“…The present experiment examined the role of the ventral striatum in the rewarding effect of morphine and amphetamine by testing whether lesions of cell bodies…”
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Dissociation in Effects of Lesions of the Nucleus Accumbens Core and Shell on Appetitive Pavlovian Approach Behavior and the Potentiation of Conditioned Reinforcement and Locomotor Activity by D-Amphetamine by Parkinson, John A, Olmstead, Mary C, Burns, Lindsay H, Robbins, Trevor W, Everitt, Barry J

“…Dopamine release within the nucleus accumbens (NAcc) has been associated with both the rewarding and locomotor-stimulant effects of abused drugs. The functions…”
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Lesions of the Pedunculopontine Tegmental Nucleus Increase Sucrose Consumption but Do Not Affect Discrimination or Contrast Effects by Olmstead, Mary C, Inglis, Wendy L, Bordeaux, Chris P, Clarke, Emily J, Wallum, Nick P, Everitt, Barry J, Robbins, Trevor W

“…Pedunculopontine tegmental nucleus (PPTg) lesions block place preferences to drugs or food only when animals are nondeprived. PPTg lesions also disrupt operant…”
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Effects of chronic cocaine on impulsivity: relation to cortical serotonin mechanisms by Paine, Tracie A., Dringenberg, Hans C., Olmstead, Mary C.

“…Drug addiction can be considered an impulse control disorder in that addicts exhibit increased impulsivity on both behavioural and self-report measures. We…”
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Lesions of the pedunculopontine tegmental nucleus abolish catalepsy and locomotor depression induced by morphine by Olmstead, M C, Franklin, K B

“…The cataleptic and locomotor depressant effects of morphine are mediated by a series of neural structures, all of which project to the pedunculopontine…”
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Basal Forebrain Cholinergic Lesions Enhance Conditioned Approach Responses to Stimuli Predictive of Food by Olmstead, Mary C, Robbins, Trevor W, Everitt, Barry J

“…This study examined the effects of lesions to different neuronal populations within the basal forebrain on reward-related learning. Rats received bilateral…”
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Adolescent enrichment partially reverses the social isolation syndrome by Hellemans, Kim G.C, Benge, Luis C, Olmstead, Mary C

“…Early environmental experience produces profound neural and behavioural effects. For example, animals reared in isolation show increased anxiety, neophobia,…”
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