Search Results - "Olmedo, Dionisio A."

Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad Rhinella alata (Anura, Bufonidae) by Rodriguez, Candelario, Ibáñez, Roberto, Olmedo, Dionisio A, Ng, Michelle, Spadafora, Carmenza, Durant-Archibold, Armando A, Gutiérrez, Marcelino

“…Amphibians are widely known as a prolific source of bioactive metabolites. In this work, we isolated and characterized compounds with antiparasitic activity…”
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Design and Diversity Analysis of Chemical Libraries in Drug Discovery by Olmedo, Dionisio A, Durant-Archibold, Armando A, López-Pérez, José Luis, Medina-Franco, José Luis

“…Chemical libraries and compound data sets are among the main inputs to start the drug discovery process at universities, research institutes, and the…”
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Latin American databases of natural products: biodiversity and drug discovery against SARS-CoV-2 by Núñez, Marvin J, Díaz-Eufracio, Bárbara I, Medina-Franco, José L, Olmedo, Dionisio A

“…In this study, we evaluated 3444 Latin American natural products using cheminformatic tools. We also characterized 196 compounds for the first time from the…”
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Understanding the Artemia Salina (Brine Shrimp) Test: Pharmacological Significance and Global Impact by Olmedo, Dionisio A, Vasquez, Yelkaira, Morán, Juan Antonio, De León, Estela Guerrero, Caballero-George, Catherina, Solís, Pablo N

“…The microplate benchtop brine shrimp test (BST) has been widely used for screening and bio-guided isolation of many active compounds, including natural…”
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Navigating the Chemical Space and Chemical Multiverse of a Unified Latin American Natural Product Database: LANaPDB by Gómez-García, Alejandro, Jiménez, Daniel A. Acuña, Zamora, William J, Barazorda-Ccahuana, Haruna L, Chávez-Fumagalli, Miguel Á, Valli, Marilia, Andricopulo, Adriano D, Bolzani, Vanderlan da S, Olmedo, Dionisio A, Solís, Pablo N, Núñez, Marvin J, Rodríguez Pérez, Johny R, Valencia Sánchez, Hoover A, Cortés Hernández, Héctor F, Medina-Franco, José L

“…The number of databases of natural products (NPs) has increased substantially. Latin America is extraordinarily rich in biodiversity, enabling the…”
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Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-κB Pathways by Olmedo, Dionisio A, López-Pérez, José Luis, Del Olmo, Esther, Bedoya, Luis M, Sancho, Rocío, Alcamí, José, Muñoz, Eduardo, Feliciano, Arturo San, Gupta, Mahabir P

“…Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones…”
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Latin American Natural Product Database (LANaPDB): An Update by Gómez-García, Alejandro, Acuña Jiménez, Daniel A, Zamora, William J, Barazorda-Ccahuana, Haruna L, Chávez-Fumagalli, Miguel Á., Valli, Marilia, Andricopulo, Adriano D, Bolzani, Vanderlan da S, Olmedo, Dionisio A, Solís, Pablo N, Núñez, Marvin J, Rodríguez Pérez, Johny R, Valencia Sánchez, Hoover A, Cortés Hernández, Héctor F, Mosquera Martinez, Oscar M, Medina-Franco, José L

“…Natural product (NP) databases are crucial tools in computer-aided drug design (CADD). Over the past decade, there has been a worldwide effort to assemble…”
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A new cytotoxic friedelane acid--pluricostatic acid--and other compounds from the leaves of Marila pluricostata by Olmedo, Dionisio A, López-Pérez, José L, del Olmo, Esther, Vásquez, Yelkaira, San Feliciano, Arturo, Gupta, Mahabir P

“…Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of…”
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Updating and profiling the natural product‐likeness of Latin American compound libraries by Gómez‐García, Alejandro, Prinz, Ann‐Kathrin, Jiménez, Daniel A. Acuña, Zamora, William J., Barazorda‐Ccahuana, Haruna L., Chávez‐Fumagalli, Miguel Á., Valli, Marilia, Andricopulo, Adriano D., S. Bolzani, Vanderlan, Olmedo, Dionisio A., Solís, Pablo N., Núñez, Marvin J., Rodríguez Pérez, Johny R., Sánchez, Hoover A. Valencia, Cortés Hernández, Héctor F., Mosquera Martinez, Oscar M., Koch, Oliver, Medina‐Franco, José L.

“…Compound databases of natural products play a crucial role in drug discovery and development projects and have implications in other areas, such as food…”
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Cheminformatic characterization of natural products from Panama by Olmedo, Dionisio A., González-Medina, Mariana, Gupta, Mahabir P., Medina-Franco, José L.

“…In this work, we discuss the characterization and diversity analysis of 354 natural products (NPs) from Panama, systematically analyzed for the first time. The…”
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Trends and challenges in chemoinformatics research in Latin America by Miranda-Salas, Jazmín, Peña-Varas, Carlos, Valenzuela Martínez, Ignacio, Olmedo, Dionisio A., Zamora, William J., Chávez-Fumagalli, Miguel Angel, Azevedo, Daniela Q., Castilho, Rachel Oliveira, Maltarollo, Vinicius G., Ramírez, David, Medina-Franco, José L.

“…Chemoinformatics is an independent inter-discipline with a broad impact in drug design and discovery, medicinal chemistry, biochemistry, analytical and organic…”
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4-Phenylcoumarins as HIV transcription inhibitors by Bedoya, Luis M., Beltrán, Manuela, Sancho, Rocío, Olmedo, Dionisio A., Sánchez-Palomino, Sonsoles, del Olmo, Esther, López-Pérez, José L., Muñoz, Eduardo, Feliciano, Arturo San, Alcamí, José

“…The inhibitory activity of natural 4-phenylcoumarins on HIV replication, NF-κB and Tat is evaluated. We have evaluated the anti-HIV activity of eleven natural…”
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Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata by Lopez-Perez, J.L, Olmedo, D.A, Olmo, E. del, Vasquez, Y, Solis, P.N, Gupta, M.P, San Feliciano, A

“…Bioassay-guided fractionation of the CH(2)Cl(2) extract of the leaves of Marila pluricostata led to the isolation of 17 naturally occurring 4-phenylcoumarins,…”
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Diayangambin exerts immunosuppressive and anti-inflammatory effects in vitro and in vivo by De León, Elvira J, Olmedo, Dionisio A, Solís, Pablo N, Gupta, Mahabir P, Terencio, M Carmen

“…In this study, the furofuran lignan (+)-diayangambin [tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-(1 R)-1alpha,3abeta,4alpha,6abeta-1 H,3 H-furo [3,4- c]furan]…”
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Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad IRhinella alata/I by Rodriguez, Candelario, Ibáñez, Roberto, Olmedo, Dionisio A, Ng, Michelle, Spadafora, Carmenza, Durant-Archibold, Armando A, Gutiérrez, Marcelino

“…Amphibians are widely known as a prolific source of bioactive metabolites. In this work, we isolated and characterized compounds with antiparasitic activity…”
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Cytotoxic 4-Phenylcoumarins from the Leaves of Marila p luricostata by López-Pérez, José L, Olmedo, Dionisio A, del Olmo, Esther, Vásquez, Yelkaira, Solís, Pablo N, Gupta, Mahabir P, San Feliciano, Arturo

“…Bioassay-guided fractionation of the CH2Cl2 extract of the leaves of Marila pluricostata led to the isolation of 17 naturally occurring 4-phenylcoumarins,…”
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Unraveling the antiviral activity of Stachytarpheta cayennensis against SARS-CoV-2 variants using in vitro and molecular docking analysis by Alvarenga, Nelson, Olmedo, Dionisio A., González-Maldonado, Pamela, Soto-Rifo, Ricardo, Valiente-Echeverría, Fernando, Langjahr, Patricia, Sotelo, Pablo H.

“…[Display omitted] •Stachytarpheta cayennensis is used in traditional medicine for COVID-19 treatment.•Butanolic fraction inhibits SARS-CoV-2 gamma and delta…”
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