Search Results - "Oliw, Ernst H."

Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens by Oliw, Ernst H.

“…•Dioxygenase-cytochrome P450 fusion enzymes are present in filamentous fungi.•They constitute a family of the peroxidase-cyclooxygenase superfamily.•The…”
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Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae by Wennman, Anneli, Oliw, Ernst H., Karkehabadi, Saeid, Chen, Yang

“…Lipoxygenases (LOX) are non-heme metal enzymes, which oxidize polyunsaturated fatty acids to hydroperoxides. All LOX belong to the same gene family, and they…”
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An allene oxide and 12-oxophytodienoic acid are key intermediates in jasmonic acid biosynthesis by Fusarium oxysporum by Oliw, Ernst H., Hamberg, Mats

“…Fungi can produce jasmonic acid (JA) and its isoleucine conjugate in large quantities, but little is known about the biosynthesis. Plants form JA from 18:3n-3…”
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Secretion of two novel enzymes, manganese 9S-lipoxygenase and epoxy alcohol synthase, by the rice pathogen Magnaporthe salvinii[S] by Wennman, Anneli, Oliw, Ernst H.

“…The mycelium of the rice stem pathogen, Magnaporthe salvinii, secreted linoleate 9S-lipoxygenase (9S-LOX) and epoxy alcohol synthase (EAS). The EAS rapidly…”
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Discovery of a linoleate 9S-dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum[S] by Hoffmann, Inga, Oliw, Ernst H.

“…Fusarium oxysporum is a devastating plant pathogen that oxidizes C18 fatty acids sequentially to jasmonates. The genome codes for putative dioxygenase…”
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A new class of fatty acid allene oxide formed by the DOX-P450 fusion proteins of human and plant pathogenic fungi, C. immitis and Z. tritici[S] by Oliw, Ernst H., Aragó, Marc, Chen, Yang, Jernerén, Fredrik

“…Linoleate dioxygenase-cytochrome P450 (DOX-CYP) fusion enzymes are common in pathogenic fungi. The DOX domains form hydroperoxy metabolites of 18:2n-6, which…”
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Crystal structure of linoleate 13R-manganese lipoxygenase in complex with an adhesion protein1 by Chen, Yang, Wennman, Anneli, Karkehabadi, Saeid, Engström, Åke, Oliw, Ernst H.

“…The crystal structure of 13R-manganese lipoxygenase (MnLOX) of Gaeumannomyces graminis (Gg) in complex with zonadhesin of Pichia pastoris was solved by…”
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Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes[S] by Hoffmann, Inga, Jernerén, Fredrik, Oliw, Ernst H.

“…The genome of the rice blast fungus Magnaporthe oryzae codes for two proteins with N-terminal dioxygenase (DOX) and C-terminal cytochrome P450 (CYP) domains,…”
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Manganese lipoxygenase of F. oxysporum and the structural basis for biosynthesis of distinct 11-hydroperoxy stereoisomers by Wennman, Anneli, Magnuson, Ann, Hamberg, Mats, Oliw, Ernst H.

“…The biosynthesis of jasmonates in plants is initiated by 13S-lipoxygenase (LOX), but details of jasmonate biosynthesis by fungi, including Fusarium oxysporum,…”
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Thirty years with three-dimensional structures of lipoxygenases by Oliw, Ernst H

“…The X-ray crystal structures of soybean lipoxygenase (LOX) and rabbit 15-LOX were reported in the 1990s. Subsequent 3D structures demonstrated a conserved…”
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Iron and manganese lipoxygenases of plant pathogenic fungi and their role in biosynthesis of jasmonates by Oliw, Ernst H.

“…Lipoxygenases (LOX) contain catalytic iron (FeLOX), but fungi also produce LOX with catalytic manganese (MnLOX). In this review, the 3D structures and…”
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Diversity of the manganese lipoxygenase gene family – A mini-review by Oliw, Ernst H.

“…•Fungi secrete lipoxygenases with catalytic manganese (MnLOX).•MnLOX-related sequences form a gene family with three subfamilies.•The six characterized MnLOX…”
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Enantiomeric separation and analysis of unsaturated hydroperoxy fatty acids by chiral column chromatography-mass spectrometry by Garscha, Ulrike, Nilsson, Tomas, Oliw, Ernst H.

“…Hydroperoxides of 18:2n-6 and 20:4n-6 were obtained by autoxidation and photooxidation. The enantiomers were separated as free acids (Reprosil Chiral-NR…”
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Linoleate diol synthase related enzymes of the human pathogens Histoplasma capsulatum and Blastomyces dermatitidis by Oliw, Ernst H.

“…Histoplasma capsulatum is an ascomyceteous fungus and a human lung pathogen, which is present in river valleys of the Americas and other continents. H…”
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Factors influencing the rearrangement of bis-allylic hydroperoxides by manganese lipoxygenase by Oliw, Ernst H.

“…Manganese lipoxygenase (Mn-LOX) catalyzes the rearrangement of bis-allylic S-hydroperoxides to allylic R-hydroperoxides, but little is known about the reaction…”
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Biochemical Characterization of the Oxygenation of Unsaturated Fatty Acids by the Dioxygenase and Hydroperoxide Isomerase of Pseudomonas aeruginosa 42A2 by Martínez, Eriel, Hamberg, Mats, Busquets, Montse, Díaz, Pilar, Manresa, Angeles, Oliw, Ernst H.

“…We have studied oxygenation of fatty acids by cell extract of Pseudomonas aeruginosa 42A2. Oleic acid ((9Z)-18:1) was transformed to…”
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WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi by Oliw, Ernst H

“…This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier…”
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Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases by Oliw, Ernst H., Wennman, Anneli, Hoffmann, Inga, Garscha, Ulrike, Hamberg, Mats, Jernerén, Fredrik

“…Seven Z-octadecenoic acids having the double bond located in positions 6Z to 13Z were photooxidized. The resulting hydroperoxy-E-octadecenoic acids [HpOME(E)]…”
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The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus by Kunz, Tina, Oliw, Ernst H.

“…Treatment of male Sprague–Dawley rats with kainic acid (10 mg/kg, i.p.) triggered limbic seizures in 60% of the animals starting within 30 min and lasting for…”
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Product specificity of fungal 8R- and 9S-dioxygenases of the peroxidase-cyclooxygenase superfamily with amino acid derivatized polyenoic fatty acids by Oliw, Ernst H.

“…Pathogenic fungi express fatty acid dioxygenases (DOX) fused to cytochromes P450 with diol or allene oxide synthase activities. The orientation of the fatty…”
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