Search Results - "Oliw, E. H."

The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus by Kunz, Tina, Oliw, Ernst H.

“…Treatment of male Sprague–Dawley rats with kainic acid (10 mg/kg, i.p.) triggered limbic seizures in 60% of the animals starting within 30 min and lasting for…”
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cDNA Cloning and Expression of CYP4F12, a Novel Human Cytochrome P450 by Bylund, Johan, Bylund, Mattias, Oliw, Ernst H.

“…cDNA of a novel human cytochrome P450 was cloned from human liver by reverse transcription-polymerase chain reaction and designated CYP4F12. The open reading…”
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Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenases by Oliw, E H

“…Polyunsaturated fatty acids can be oxygenated by P450 in different ways--by epoxidation, by hydroxylation of the omega-side chain, by allylic and bis-allylic…”
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A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid by BRODOWSKY, I. D, HAMBERG, M, OLIW, E. H

“…The fungus Gaeumannomyces graminis metabolized linoleic acid extensively to (8R)-hydroperoxylinoleic acid, (8R)-hydroxylinoleic acid, and…”
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Assignment of EPR Transitions in a Manganese-Containing Lipoxygenase and Prediction of Local Structure by Gaffney, B J, Su, C, Oliw, E H

“…A new variant of lipoxygenases, one containing manganese instead of iron, is characterized by electron paramagnetic resonance (EPR) at two frequencies. In the…”
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LC–MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22 by Nilsson, T., Ivanov, I.V., Oliw, E.H.

“…CYP4F22 and CYP4F8 are expressed in epidermis, and mutations of CYP4F22 are associated with lamellar ichthyosis. Epoxyalcohols (HEETs) and epoxides (EETs) of…”
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Studies of Lipoxygenases in the Epithelium of Cultured Bovine Cornea Using an Air Interface Model by Liminga, Maria, Oliw, Ernst H

“…Epithelial lipoxygenases of bovine cornea were investigated in organ culture models. Subcellular fractions of the epithelium were incubated with14C-labelled…”
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Arachidonic acid 15-lipoxygenase and traces of E prostaglandins in purified human prostasomes by Oliw, E H, Fabiani, R, Johansson, L, Ronquist, G

“…Human spermatozoa are associated with arachidonate 15-lipoxygenase activity. This activity could be due to 15-lipoxygenase in small organelles (prostasomes),…”
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Biosynthesis of 18(RD)-hydroxyeicosatetraenoic acid from arachidonic acid by microsomes of monkey seminal vesicles. Some properties of a novel fatty acid omega 3-hydroxylase and omega 3-epoxygenase by Oliw, E H

“…Microsomes of seminal vesicles of the cynomolgus monkey were incubated with [14C]5,8,11,14-eicosatetraenoic (arachidonic) acid and NADPH for 40 min at 37…”
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Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates by Oliw, E H, Guengerich, F P, Oates, J A

“…[3H]Arachidonic (eicosatetraenoic) acid was incubated with rabbit liver microsomes, NADPH, and 1 mM 1,2-epoxy-3,3,3-trichloropropane, an epoxide hydrolase…”
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Manganese lipoxygenase. Purification and characterization by Su, C. (Uppsala Biomedical Center, Sweden), Oliw, E.H

“…A linoleic acid (13R)-lipoxygenase was purified to homogeneity from the culture medium of Gäumannomyces graminis, the take-all fungus, by hydrophobic…”
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Biochemical characterization of prostaglandin 19-hydroxylase of seminal vesicles by Oliw, E H, Kinn, A C, Kvist, U

“…The microsomal fraction of homogenates of seminal vesicles of men and monkeys, Macaca fascicularis, were analyzed for prostaglandin (PG) 19-hydroxylase…”
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Metabolism of 5(6)Oxidoeicosatrienoic acid by ram seminal vesicles. Formation of two stereoisomers of 5-hydroxyprostaglandin I1 by Oliw, E H

“…Cytochrome P-450 can metabolize arachidonic (5,8,11,14-eicosatetraenoic) acid to four epoxides. One of them, cis-5(6)oxido-8,11,14-eicosatrienoic acid, has…”
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Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids by Oliw, E H, Brodowsky, I D, Hörnsten, L, Hamberg, M

“…[14C]Linoleic acid was incubated with phenobarbital-induced rat liver microsomes and formation of cis-trans-conjugated hydroxy fatty acids was investigated…”
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Kinetics of Manganese Lipoxygenase with a Catalytic Mononuclear Redox Center by Su, Chao, Sahlin, Margareta, Oliw, Ernst H.

“…Manganese lipoxygenase was isolated from the take-all fungus, Gaeumannomyces graminis, and the oxygenation mechanism was investigated. A kinetic isotope…”
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Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by bovine corneal epithelium by Oliw, E H

“…Microsomes of bovine corneal epithelium metabolized [14C]arachidonic acid extensively to [14C]12-hydroxyeicosatetraenoic acid. The biosynthesis was not…”
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Rapid and slow hydroxylators of seminal E prostaglandins among men in barren unions by Pourian, M R, Kvist, U, Björndahl, L, Oliw, E H

“…E prostaglandins are formed in seminal vesicles and can be oxygenated by (omega-1)-hydroxylation catalysed by cytochrome P450 to 19(R)-hydroxy metabolites. The…”
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Identification of CYP4F8 in Human Seminal Vesicles as a Prominent 19-Hydroxylase of Prostaglandin Endoperoxides by Bylund, Johan, Hidestrand, Mats, Ingelman-Sundberg, Magnus, Oliw, Ernst H.

“…A novel cytochrome P450, CYP4F8, was recently cloned from human seminal vesicles. CYP4F8 was expressed in yeast. Recombinant CYP4F8 oxygenated arachidonic acid…”
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Isolation and biosynthesis of 20-hydroxyprostaglandins E1 and E2 in ram seminal fluid by Oliw, E H, Fahlstadius, P, Hamberg, M

“…Ram semen was found to contain 20-hydroxyprostaglandin E1 and 20-hydroxyprostaglandin E2. The relative amounts of the two compounds were almost equal, although…”
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Lipoxygenases in corneal epithelia of man and cynomolgus monkey by Liminga, M, Fagerholm, P, Oliw, E H

“…Human and monkey corneal epithelia were investigated for lipoxygenases. The low-speed supernatant of human corneal epithelium converted arachidonic acid to one…”
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