Search Results - "Olivier Lesur"

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans by Solana, Rafael, Tarazona, Raquel, Gayoso, Inmaculada, Lesur, Olivier, Dupuis, Gilles, Fulop, Tamas

“…Highlights ► Aging affects the phenotype and functions of cells of innate immunity. ► Expression and function of innate receptors on phagocytes is altered in…”
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D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF) by Merk, Melanie, Zierow, Swen, Leng, Lin, Das, Rituparna, Du, Xin, Schulte, Wibke, Fan, Juan, Lue, Hongqi, Chen, Yibang, Xiong, Huabao, Chagnon, Frederic, Bernhagen, Jürgen, Lolis, Elias, Mor, Gil, Lesur, Olivier, Bucala, Richard

“…Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response. Neutralization or genetic deletion of MIF does not completely…”
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Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients by Coquerel, David, Lamoureux, Julie, Chagnon, Frédéric, Trân, Kien, Sage, Michael, Fortin-Pellerin, Etienne, Delile, Eugénie, Sainsily, Xavier, Fournier, Justin, Dumont, Audrey-Ann, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Eric, Praud, Jean-Paul, Fülöp, Tamàs, Lesur, Olivier

“…Sepsis is a prevalent life-threatening condition related to a systemic infection, and with unresolved issues including refractory septic shock and organ…”
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Hemodynamic support in the early phase of septic shock: a review of challenges and unanswered questions by Lesur, Olivier, Delile, Eugénie, Asfar, Pierre, Radermacher, Peter

“…Background Improving sepsis support is one of the three pillars of a 2017 resolution according to the World Health Organization (WHO). Septic shock is indeed a…”
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Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock by Salvail, William, Salvail, Dany, Chagnon, Frédéric, Lesur, Olivier

“…Background Infusion of exogenous catecholamines (i.e., norepinephrine [NE] and dobutamine) is a recommended treatment for septic shock with myocardial…”
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Ventriculo-arterial (un)coupling in septic shock: Impact of current and upcoming hemodynamic drugs by Demailly, Zoé, Besnier, Emmanuel, Tamion, Fabienne, Lesur, Olivier

“…Sepsis is an archetype of distributive shock and combines different levels of alterations in preload, afterload, and often cardiac contractility. The use of…”
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Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis by Besnier, Emmanuel, Coquerel, David, Kouadri, Geoffrey, Clavier, Thomas, Favory, Raphael, Duburcq, Thibault, Lesur, Olivier, Bekri, Soumeya, Richard, Vincent, Mulder, Paul, Tamion, Fabienne

“…Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and…”
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The apelinergic system as an alternative to catecholamines in low-output septic shock by Coquerel, David, Sainsily, Xavier, Dumont, Lauralyne, Sarret, Philippe, Marsault, Éric, Auger-Messier, Mannix, Lesur, Olivier

“…Catecholamines, in concert with fluid resuscitation, have long been recommended in the management of septic shock. However, not all patients respond positively…”
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Vasopressin or norepinephrine in early hyperdynamic septic shock : a randomized clinical trial by LAUZIER, Francois, LEVY, Bruno, LAMARRE, Patrice, LESUR, Olivier

“…To compare the effects of arginine-vasopressin (AVP) and norepinephrine (NE) on hemodynamic variables, organ dysfunction, and adverse events in early…”
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Thrombocytopenia in the critically ill: prevalence, incidence, risk factors, and clinical outcomes by Williamson, David R., Lesur, Olivier, Tétrault, Jean-Pierre, Nault, Vincent, Pilon, Danielle

“…Purpose The aim of this cohort study was to describe the prevalence, incidence, and risk factors for thrombocytopenia in the intensive care unit (ICU) and to…”
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C‑Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action by Murza, Alexandre, Besserer-Offroy, Élie, Côté, Jérôme, Bérubé, Patrick, Longpré, Jean-Michel, Dumaine, Robert, Lesur, Olivier, Auger-Messier, Mannix, Leduc, Richard, Sarret, Philippe, Marsault, Éric

“…Apelin is the endogenous ligand of the APJ receptor, a member of the G protein-coupled receptor family. This system plays an important role in the regulation…”
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Music and biological stress dampening in mechanically-ventilated patients at the intensive care unit ward—a prospective interventional randomized crossover trial by Beaulieu-Boire, Genevieve, MD, Bourque, Solange, MD, Chagnon, Frederic, MSc, Chouinard, Lucie, BsC, Gallo-Payet, Nicole, PhD, Lesur, Olivier, MD PhD

“…Abstract Purpose To evaluate the impact of slow-tempo music listening periods in mechanically ventilated intensive care unit patients. Methods A randomized…”
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Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake by Sainsily, Xavier, Coquerel, David, Giguère, Hugo, Dumont, Lauralyne, Tran, Kien, Noll, Christophe, Ionescu, Andrei L., Côté, Jérôme, Longpré, Jean-Michel, Carpentier, André, Marsault, Éric, Lesur, Olivier, Sarret, Philippe, Auger-Messier, Mannix

“…Objectives: Arterial hypertension, when exacerbated by excessive dietary salt intake, worsens the morbidity and mortality rates associated with cardiovascular…”
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Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4 by Fortin, Carl F., Lesur, Olivier, Fulop, Tamas

“…Neutrophilic polymorphonuclears (PMNs) play an important role in the progression of sepsis-related inflammation and become highly activated by a wide array of…”
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Heparin-induced thrombocytopenia in the critically ill: Interpreting the 4Ts test in a randomized trial by Crowther, Mark, MD, Cook, Deborah, MD, Guyatt, Gordon, MD, Zytaruk, Nicole, RN, McDonald, Ellen, RN, Williamson, David, MSc, Albert, Martin, MD, Dodek, Peter, MD, Finfer, Simon, MD, Vallance, Shirley, RN, Heels-Ansdell, Diane, MSc, McIntyre, Lauralyn, MD, Mehta, Sangeeta, MD, Lamontagne, Francois, MD, Muscedere, John, MD, Jacka, Michael, MD, Lesur, Olivier, MD, Kutsiogiannis, Jim, MD, Friedrich, Jan, MD, Klinger, James R., MD, Qushmaq, Ismael, MD, Burry, Lisa, PharmD, Khwaja, Kosar, MD, Sheppard, Jo-Ann, BSc, Warkentin, Theodore E., MD

“…Abstract Background Thrombocytopenia occurs in 20% to 45% of critically ill medical-surgical patients. The 4Ts heparin-induced thrombocytopenia (HIT) score…”
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Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions by Carl F. Fortin, Anis Larbi, Olivier Lesur, Nadine Douziech, Tamas Fulop, Jr

“…It has been shown that the functions and the rescue from apoptosis by proinflammatory mediators of polymorphonuclear leukocytes (PMN) tend to diminish with…”
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Improving the evaluation of cardiac function in rats at 7T with denoising filters: a comparison study by Tricot, Benoit, Descoteaux, Maxime, Dumont, Matthieu, Chagnon, Frederic, Tremblay, Luc, Carpentier, André, Lesur, Olivier, Lepage, Martin, Lalande, Alain

“…We investigate the use of different denoising filters on low signal-to-noise ratio cardiac images of the rat heart acquired with a birdcage volume coil at 7T…”
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Endotoxin-induced heart dysfunction in rats: Assessment of myocardial perfusion and permeability and the role of fluid resuscitation by Chagnon, Frederic, Bentourkia, M’hamed, Lecomte, Roger, Lessard, Michel, Lesur, Olivier

“…OBJECTIVE:The pathophysiology of sepsis-induced myocardial dysfunction is still controversial. Whether microcirculatory hypoperfusion together with capillary…”
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GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals by FORTIN, Carl F, LARBI, Anis, DUPUIS, Gilles, LESUR, Olivier, FÜLÖP, Tamhs

“…Polymorphonuclear neutrophils (PMN) are the first cells to be recruited to the site of tissular aggression. They have a short-life span and die by spontaneous…”
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Adrenal Insufficiency in Septic Shock by Maxime, Virginie, MD, Lesur, Olivier, MD, PhD, Annane, Djillali, MD, PhD

“…During disease states, the endocrine axes exhibit different levels of activity according to the severity of illness. These various alterations have been widely…”
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