Search Results - "Olivier, Nelson B."

Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization by Choquet, Daniel, Imperiali, Barbara, Sainlos, Matthieu, Tigaret, Cezar, Poujol, Christel, Olivier, Nelson B, Bard, Lucie, Breillat, Christelle, Thiolon, Kevin

“…Biomimetic divalent ligands based on the PDZ domain–binding motifs from the AMPA receptor auxiliary subunit Stargazin disrupt the receptor's interaction with…”
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Structural basis for modulation and agonist specificity of HCN pacemaker channels by Zagotta, William N, Gouaux, Eric, Olivier, Nelson B, Black, Kevin D, Young, Edgar C, Olson, Rich

“…The family of hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels are crucial for a range of electrical signalling, including cardiac and…”
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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome by Olivier, Nelson B., Altman, Roger B., Noeske, Jonas, Basarab, Gregory S., Code, Erin, Ferguson, Andrew D., Gao, Ning, Huang, Jian, Juette, Manuel F., Livchak, Stephania, Miller, Matthew D., Prince, D. Bryan, Cate, Jamie H. D., Buurman, Ed T., Blanchard, Scott C.

“…Significance The identification of negamycin’s binding site within helix 34 of the small subunit head domain and the elucidation of its mechanism of action…”
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Crystal Structure and Catalytic Mechanism of PglD from Campylobacter jejuni by Olivier, Nelson B., Imperiali, Barbara

“…The carbohydrate 2, 4-diacetamido-2, 4, 6-trideoxy-α-d-glucopyranose (BacAc2) is found in a variety of eubacterial pathogens. In Campylobacter jejuni, PglD…”
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In Vitro Biosynthesis of UDP-N,N‘-Diacetylbacillosamine by Enzymes of the Campylobacter jejuni General Protein Glycosylation System by Olivier, Nelson B, Chen, Mark M, Behr, Jonathan R, Imperiali, Barbara

“…In Campylobacter jejuni 2,4-diacetamido-2,4,6-trideoxy-α-d-glucopyranose, termed N,N‘-diacetylbacillosamine (Bac2,4diNAc), is the first carbohydrate in the…”
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Structural biology: Ribosome revelations by Olivier, Nelson B

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Ribosome revelations by Olivier, Nelson B.

“…Proteins are synthesized in cells by the ribosome apparatus. A report of 16 yeast ribosome structures, each bound by a different inhibitor, broadens our…”
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C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels by Craven, Kimberley B., Olivier, Nelson B., Zagotta, William N.

“…Activation of cyclic nucleotide-modulated channels such as CNG and HCN channels is promoted by ligand-induced conformational changes in their C-terminal…”
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ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii by Durand-Réville, Thomas F., Guler, Satenig, Comita-Prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B., McLeod, Sarah M., Carter, Nicole M., Moussa, Samir H., Velez-Vega, Camilo, Olivier, Nelson B., McLaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A., Newman, Joseph V., Ehmann, David E., de Jonge, Boudewijn, O'Donnell, John, Mueller, John P., Tommasi, Rubén A., Miller, Alita A.

“…Multidrug-resistant (MDR) bacterial infections are a serious threat to public health. Among the most alarming resistance trends is the rapid rise in the number…”
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Mapping the structure and conformational movements of proteins with transition metal ion FRET by Zagotta, William N, Taraska, Justin W, Puljung, Michael C, Olivier, Nelson B, Flynn, Galen E

“…Fluorescence resonance energy transfer (FRET) between a small-molecule fluorophore donor and a transition metal ion acceptor, a method called 'transition metal…”
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Synergy of streptogramin antibiotics occurs independently of their effects on translation by Noeske, Jonas, Huang, Jian, Olivier, Nelson B, Giacobbe, Robert A, Zambrowski, Mark, Cate, Jamie H D

“…Streptogramin antibiotics are divided into types A and B, which in combination can act synergistically. We compared the molecular interactions of the…”
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Crystal structure of A. aeolicus LpxC with bound product suggests alternate deacetylation mechanism by Miller, Matthew D., Gao, Ning, Ross, Philip L., Olivier, Nelson B.

“…ABSTRACT UDP‐3‐O‐acyl‐N‐acetylglucosamine deacetylase (LpxC) is the first committed step to form lipid A, an essential component of the outer membrane of…”
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Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region by Kawatkar, Sameer P, Keating, Thomas A, Olivier, Nelson B, Breen, John N, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Loch, James T, McKenzie, Andrew R, Newman, Joseph V, Otterson, Linda G, Martínez-Botella, Gabriel

“…Thymidylate kinase (TMK), an essential enzyme in bacterial DNA biosynthesis, is an attractive therapeutic target for the development of novel antibacterial…”
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Structural Analysis of WbpE from Pseudomonas aeruginosa PAO1: A Nucleotide Sugar Aminotransferase Involved in O-Antigen Assembly by Larkin, Angelyn, Olivier, Nelson B, Imperiali, Barbara

“…In recent years, the opportunistic pathogen Pseudomonas aeruginosa has emerged as a major source of hospital-acquired infections. Effective treatment has…”
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Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions by Sainlos, Matthieu, Iskenderian-Epps, Wendy S, Olivier, Nelson B, Choquet, Daniel, Imperiali, Barbara

“…We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a…”
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Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK) by Martínez-Botella, Gabriel, Breen, John N, Duffy, James E. S, Dumas, Jacques, Geng, Bolin, Gowers, Ian K, Green, Oluyinka M, Guler, Satenig, Hentemann, Martin F, Hernandez-Juan, Felix A, Joseph-McCarthy, Diane, Kawatkar, Sameer, Larsen, Nicholas A, Lazari, Ovadia, Loch, James T, Macritchie, Jacqueline A, McKenzie, Andrew R, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Owens, Andrew P, Read, Jon, Sheppard, David W, Keating, Thomas A

“…Thymidylate kinase (TMK) is an essential enzyme in bacterial DNA synthesis. The deoxythymidine monophosphate (dTMP) substrate binding pocket was targeted in a…”
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Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK) by Martínez-Botella, Gabriel, Loch, James T., Green, Oluyinka M., Kawatkar, Sameer P., Olivier, Nelson B., Boriack-Sjodin, P. Ann, Keating, Thomas A.

“…Thymidylate kinase (TMK) is an essential enzyme for DNA synthesis in bacteria, phosphorylating deoxythymidine monophosphate (dTMP) to deoxythymidine…”
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In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound by Keating, Thomas A, Newman, Joseph V, Olivier, Nelson B, Otterson, Linda G, Andrews, Beth, Boriack-Sjodin, P. Ann, Breen, John N, Doig, Peter, Dumas, Jacques, Gangl, Eric, Green, Oluyinka M, Guler, Satenig Y, Hentemann, Martin F, Joseph-McCarthy, Diane, Kawatkar, Sameer, Kutschke, Amy, Loch, James T, McKenzie, Andrew R, Pradeepan, Selvi, Prasad, Swati, Martínez-Botella, Gabriel

“…There is an urgent need for new antibacterials that pinpoint novel targets and thereby avoid existing resistance mechanisms. We have created novel synthetic…”
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Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain by Gao, Ning, McLeod, Sarah M., Hajec, Laurel, Olivier, Nelson B., Lahiri, Sushmita D., Bryan Prince, D., Thresher, Jason, Ross, Philip L., Whiteaker, James D., Doig, Peter, Li, Amanda Haixi, Hill, Pamela J., Cornebise, Mark, Reck, Folkert, Hale, Michael R.

“…•P. aeruginosa LpxC forms soluble aggregates when expressed in E. coli.•Expression in the presence of LpxC inhibitors greatly increases LpxC…”
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A Conserved Tripeptide in CNG and HCN Channels Regulates Ligand Gating by Controlling C-Terminal Oligomerization by Zhou, Lei, Olivier, Nelson B., Yao, Huan, Young, Edgar C., Siegelbaum, Steven A.

“…Cyclic nucleotides directly enhance the opening of the tetrameric CNG and HCN channels, although the mechanism remains unclear. We examined why HCN and certain…”
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