Search Results - "Olivier, Jean Luc"

Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants by Turner, Jonathan D., Olivier, Jean-Luc, Schroeder, Henri, Grova, Nathalie

“…The incidence of neurodevelopmental and neurodegenerative diseases worldwide has dramatically increased over the last decades. Although the aetiology remains…”
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Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway by Malaplate-Armand, Catherine, Florent-Béchard, Sabrina, Youssef, Ihsen, Koziel, Violette, Sponne, Isabelle, Kriem, Badreddine, Leininger-Muller, Brigitte, Olivier, Jean-Luc, Oster, Thierry, Pillot, Thierry

“…Recent data have revealed that soluble oligomeric amyloid-beta peptide (Abeta) may be the proximate effectors of neuronal injuries and death in Alzheimer's…”
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Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers by Florent, Sabrina, Malaplate‐Armand, Catherine, Youssef, Ihsen, Kriem, Badreddine, Koziel, Violette, Escanyé, Marie‐Christine, Fifre, Alexandre, Sponne, Isabelle, Leininger‐Muller, Brigitte, Olivier, Jean‐Luc, Pillot, Thierry, Oster, Thierry

“…A growing body of evidence supports the notion that soluble oligomers of amyloid‐β (Aβ) peptide interact with the neuronal plasma membrane, leading to cell…”
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Brain region-specific immunolocalization of the lipolysis-stimulated lipoprotein receptor (LSR) and altered cholesterol distribution in aged LSR+/− mice by Stenger, Christophe, Pinçon, Anthony, Hanse, Marine, Royer, Laurent, Comte, Audrey, Koziel, Violette, Olivier, Jean-Luc, Pillot, Thierry, Yen, Frances T.

“…Brain lipid homeostasis is important for maintenance of brain cell function and synaptic communications, and is intimately linked to age‐related cognitive…”
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Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance by Thomas, Mnlanie H, Paris, Cndric, Magnien, Mylene, Colin, Julie, Pelleieux, Sandra, Coste, Florence, Escanyn, Marie-Christine, Pillot, Thierry, Olivier, Jean-Luc

“…BACKGROUNDPolyunsaturated fatty acids play a crucial role in neuronal function, and the modification of these compounds in the brain could have an impact on…”
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Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid‐β peptide by Kriem, Badreddine, Sponne, Isabelle, Fifre, Alexandre, Malaplate‐Armand, Catherine, Lozac'h‐Pillot, Karine, Koziel, Violette, Yen‐Potin, Frances T., Bihain, Bernard, Oster, Thierry, Olivier, Jean‐Luc, Pillot, Thierry

“…ABSTRACT Recent data have revealed that soluble oligomeric forms of amyloid peptide (Aβ) may be the proximate effectors of the neuronal injury and death…”
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The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study by Oussalah, Abderrahim, Gleye, Stanislas, Urmes, Isabelle Clerc, Laugel, Elodie, Barbé, Françoise, Orlowski, Sophie, Malaplate, Catherine, Aimone-Gastin, Isabelle, Caillierez, Beatrice Maatem, Merten, Marc, Jeannesson, Elise, Kormann, Raphaël, Olivier, Jean-Luc, Rodriguez-Guéant, Rosa-Maria, Namour, Farès, Bevilacqua, Sybille, Thilly, Nathalie, Losser, Marie-Reine, Kimmoun, Antoine, Frimat, Luc, Levy, Bruno, Gibot, Sébastien, Schvoerer, Evelyne, Guéant, Jean-Louis

“…In patients with severe COVID-19, no data are available on the longitudinal evolution of biochemical abnormalities and their ability to predict disease…”
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Up-regulation of hepatic lipolysis stimulated lipoprotein receptor by leptin: a potential lever for controlling lipid clearance during the postprandial phase by Stenger, Christophe, Hanse, Marine, Pratte, Dagmar, Mbala, Marie-Ludvine, Akbar, Samina, Koziel, Violette, Escanyé, Marie-Christine, Kriem, Badreddine, Malaplate-Armand, Catherine, Olivier, Jean-Luc, Oster, Thierry, Pillot, Thierry, Yen, Frances T

“…As a hepatic receptor for triglyceride-rich lipoproteins, the lipolysis-stimulated lipoprotein receptor (LSR) may be involved in the dynamics of lipid…”
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Towards a nutritional approach for prevention of Alzheimer's disease: Biochemical and cellular aspects by Florent-Béchard, Sabrina, Malaplate-Armand, Catherine, Koziel, Violette, Kriem, Badreddine, Olivier, Jean-Luc, Pillot, Thierry, Oster, Thierry

“…Abstract Alzheimer's disease (AD) is a major public health concern in all countries. Although the precise cause of AD is still unknown, a growing body of…”
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Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France by Oussalah, Abderrahim, Gleye, Stanislas, Clerc Urmes, Isabelle, Laugel, Elodie, Callet, Jonas, Barbé, Françoise, Orlowski, Sophie, Malaplate, Catherine, Aimone-Gastin, Isabelle, Caillierez, Beatrice Maatem, Merten, Marc, Jeannesson, Elise, Kormann, Raphaël, Olivier, Jean-Luc, Rodriguez-Guéant, Rosa-Maria, Namour, Farès, Bevilacqua, Sybille, Losser, Marie-Reine, Levy, Bruno, Kimmoun, Antoine, Gibot, Sébastien, Thilly, Nathalie, Frimat, Luc, Schvoerer, Evelyne, Guéant, Jean-Louis

“…Abstract Background In patients with severe coronavirus disease 2019 (COVID-19), data are scarce and conflicting regarding whether chronic use of…”
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Dietary arachidonic acid as a risk factor for age-associated neurodegenerative diseases: Potential mechanisms by Thomas, Mélanie H., Pelleieux, Sandra, Vitale, Nicolas, Olivier, Jean Luc

“…Alzheimer's disease and associated diseases constitute a major public health concern worldwide. Nutrition-based, preventive strategies could possibly be…”
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Cerebrospinal Fluid Aβ42/Aβ40 as a Means to Limiting Tube- and Storage-Dependent Pre-Analytical Variability in Clinical Setting by Gervaise-Henry, Christelle, Watfa, Gasshan, Albuisson, Eliane, Kolodziej, Allan, Dousset, Brigitte, Olivier, Jean-Luc, Jonveaux, Thérèse Rivasseau, Malaplate-Armand, Catherine

“…Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers have recently been included in the criteria for AD diagnosis. Unfortunately, their wider use in…”
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Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease by Garcia, Pierre, Youssef, Ihsen, Utvik, Jo K, Florent-Béchard, Sabrina, Barthélémy, Vanassa, Malaplate-Armand, Catherine, Kriem, Badreddine, Stenger, Christophe, Koziel, Violette, Olivier, Jean-Luc, Escanye, Marie-Christine, Hanse, Marine, Allouche, Ahmad, Desbène, Cédric, Yen, Frances T, Bjerkvig, Rolf, Oster, Thierry, Niclou, Simone P, Pillot, Thierry

“…The development of novel therapeutic strategies for Alzheimer's disease (AD) represents one of the biggest unmet medical needs today. Application of…”
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Impact of Dietary Arachidonic Acid on Gut Microbiota Composition and Gut-Brain Axis in Male BALB/C Mice by Pinchaud, Katleen, Hafeez, Zeeshan, Auger, Sandrine, Chatel, Jean-Marc, Chadi, Sead, Langella, Philippe, Paoli, Justine, Dary-Mourot, Annie, Maguin-Gaté, Katy, Olivier, Jean Luc

“…Although arachidonic acid (ARA) is the precursor of the majority of eicosanoids, its influence as a food component on health is not well known. Therefore, we…”
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Dietary arachidonic acid: a Janus face actor in brain and Alzheimer’s disease? by Pinchaud, Katleen, Maguin-Gaté, Katy, Olivier, Jean-Luc

“…Arachidonic acid is the second polyunsaturated fatty acid in brain and the first one belonging to the ω-6 series. Dietary intakes of arachidonic are between 50…”
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N-truncated amyloid-β oligomers induce learning impairment and neuronal apoptosis by Youssef, Ihsen, Florent-Béchard, Sabrina, Malaplate-Armand, Catherine, Koziel, Violette, Bihain, Bernard, Olivier, Jean-Luc, Leininger-Muller, Brigitte, Kriem, Badreddine, Oster, Thierry, Pillot, Thierry

“…Abstract N-terminal-truncated forms of amyloid-β (Aβ) peptide have been recently suggested to play a pivotal role early in Alzheimer's disease (AD). Among…”
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Oligodendrocytes are susceptible to apoptotic cell death induced by prion protein-derived peptides by Sponne, Isabelle, Fifre, Alexandre, Koziel, Violette, Kriem, Badreddine, Oster, Thierry, Olivier, Jean-Luc, Pillot, Thierry

“…Neurodegenerative prion diseases, characterized by a progressive dementia, are associated with the accumulation of abnormal forms of the prion (PrPc) protein,…”
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Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid beta-peptide-induced neuronal apoptosis. Synergistic involvement of calpain and caspase-3 by Fifre, Alexandre, Sponne, Isabelle, Koziel, Violette, Kriem, Badreddine, Yen Potin, Frances T, Bihain, Bernard E, Olivier, Jean-Luc, Oster, Thierry, Pillot, Thierry

“…A growing body of evidence supports the notion that soluble oligomeric forms of the amyloid beta-peptide (Abeta) may be the proximate effectors of neuronal…”
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Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of the amyloid‐β peptide by Sponne, Isabelle, Fifre, Alexandre, Kriem, Badreddine, Koziel, Violette, Bihain, Bernard, Oster, Thierry, Olivier, Jean-Luc, Pillot, Thierry

“…ABSTRACT Neuronal cell death in Alzheimer's disease (AD) is partly induced by the interaction of the amyloid‐β peptide (Aβ) with the plasma membrane of target…”
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Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation by Sponne, Isabelle, Fifre, Alexandre, Drouet, Béatrice, Klein, Christophe, Koziel, Violette, Pinçon-Raymond, Martine, Olivier, Jean-Luc, Chambaz, Jean, Pillot, Thierry

“…In the present study, we have determined the nature and the kinetics of the cellular events triggered by the exposure of cells to non-fibrillar amyloid-beta…”
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