Search Results - "Olivier, J.M"

Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors by Janssen, Antonius P.A, van Hengst, Jacob M.A, Béquignon, Olivier J.M, Deng, Hui, van Westen, Gerard J.P, van der Stelt, Mario

“…Drug discovery programs of covalent irreversible, mechanism-based enzyme inhibitors often focus on optimization of potency as determined by IC50-values in…”
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Biochemical and physiological aspects of brown blotch disease of Agaricus bisporus by Soler-Rivas, C., Jolivet, S., Arpin, N., Olivier, J.M., Wichers, H.J.

“…Abstract Pseudomonas tolaasii is a bacterium endemic to the compost beds where common mushroom (Agaricus bisporus) is cultivated. Under some environmental…”
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Prognostic Value of Tumor Deposits for Disease-Free Survival in Patients With Stage III Colon Cancer: A Post Hoc Analysis of the IDEA France Phase III Trial (PRODIGE-GERCOR) by Delattre, Jean-François, Cohen, Romain, Henriques, Julie, Falcoz, Antoine, Emile, Jean-François, Fratte, Serge, Chibaudel, Benoist, Dauba, Jérôme, Dupuis, Olivier, Bécouarn, Yves, Bibeau, Frédéric, Taieb, Julien, Louvet, Christophe, Vernerey, Dewi, André, Thierry, Svrcek, Magali

“…A post hoc analysis of all pathologic reports from patients with stage III CC included in the IDEA France phase III study (ClinicalTrials.gov identifier:…”
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WLIP, a lipodepsipeptide of Pseudomonas ‘reactans’, as inhibitor of the symptoms of the brown blotch disease of Agaricus bisporus by Soler‐Rivas, C., Arpin, N., Olivier, J. M., Wichers, H. J.

“…A cell‐free crude extract containing the white line inducing principle (WLIP), a lipodepsipeptide produced by Pseudomonas ‘reactans’, could inhibit browning of…”
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3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake by Aceves, Jeffrey O., Heja, Szilvia, Kobayashi, Kenichi, Robinson, Sanlin S., Miyoshi, Tomoya, Matsumoto, Takuya, Schäffers, Olivier J. M., Morizane, Ryuji, Lewis, Jennifer A.

“…Three-dimensional, organ-on-chip models that recapitulate kidney tissue are needed for drug screening and disease modeling. Here, we report a method for…”
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Note on a stepwise procedure for rejecting at least k out of m hypotheses: A simple Holm‐type formulation and proof by Guilbaud, Olivier J. M.

“…Mielke et al. (2021) proposed a stepwise multiple testing procedure (MTP) based on marginal p‐values for rejecting at least k out of m null hypotheses…”
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DrugEx: Deep Learning Models and Tools for Exploration of Drug-Like Chemical Space by Šícho, Martin, Luukkonen, Sohvi, van den Maagdenberg, Helle W., Schoenmaker, Linde, Béquignon, Olivier J. M., van Westen, Gerard J. P.

“…The discovery of novel molecules with desirable properties is a classic challenge in medicinal chemistry. With the recent advancements of machine learning,…”
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CC chemokine receptor 2 is allosterically modulated by sodium ions and amiloride derivatives through a distinct sodium ion binding site by den Hollander, Lisa S., Zweemer, Annelien J.M., Béquignon, Olivier J.M., Hammerl, Dora M., Bleijs, Bente T.M., Veenhuizen, Margo, Lantsheer, Wernard J.F., Chau, Bobby, van Westen, Gerard J.P., IJzerman, Adriaan P., Heitman, Laura H.

“…[Display omitted] CC chemokine receptor 2 and CCL2 are highly involved in cancer growth and metastasis, and immune escape. Raised sodium ion concentrations in…”
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The goby fish Sicydium spp. as valuable sentinel species towards the chemical stress in freshwater bodies of West Indies by Bony, S., Labeille, M., Lefrancois, E., Noury, P., Olivier, J.M., Santos, R., Teichert, N., Besnard, A., Devaux, A.

“…•Hepatic EROD activity in the fish Sicydium spp. can be used as a sensitive biomarker of exposure to pollutants.•Genotoxicity endpoints inform about the…”
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Bsn-t alleles from French field strains of Agaricus bisporus by Callac, P. (INRA, Villenave d'Ornon, France.), Hocquart, S, Imbernon, M, Desmerger, C, Olivier, J.M

“…In the Agaricus bisporus desert population in California, the dominant Bsn-t allele determines the production of tetrasporic basidia and homokaryotic spores…”
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The rise and fall of novel renal magnesium transporters by Schäffers, Olivier J M, Hoenderop, Joost G J, Bindels, René J M, de Baaij, Jeroen H F

“…Body Mg balance is finely regulated in the distal convoluted tubule (DCT), where a tight interplay among transcellular reabsorption, mitochondrial exchange,…”
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Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells by Béquignon, Olivier J. M., Gómez-Tamayo, Jose C., Lenselink, Eelke B., Wink, Steven, Hiemstra, Steven, Lam, Chi Chung, Gadaleta, Domenico, Roncaglioni, Alessandra, Norinder, Ulf, Water, Bob van de, Pastor, Manuel, van Westen, Gerard J. P.

“…Oxidative stress is the consequence of an abnormal increase of reactive oxygen species (ROS). ROS are generated mainly during the metabolism in both normal and…”
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Some Complementary History and Results by Guilbaud, Olivier J. M.

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UnCorrupt SMILES: a novel approach to de novo design by Schoenmaker, Linde, Béquignon, Olivier J. M., Jespers, Willem, van Westen, Gerard J. P.

“…Generative deep learning models have emerged as a powerful approach for de novo drug design as they aid researchers in finding new molecules with desired…”
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Renal Regeneration: Stem Cell-Based Therapies to Battle Kidney Disease by Matsumoto, Takuya, Schäffers, Olivier J.M., Yin, Wenqing, Morizane, Ryuji

“…While the worldwide prevalence of kidney disease is increasing rapidly, the current therapeutic repertoire for these patients is often limited to dialysis and…”
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EDITOR’S PICK: RENAL REGENERATION: STEM CELL-BASED THERAPIES TO BATTLE KIDNEY DISEASE by Takuya Matsumoto, Olivier J.M. Schäffers, Wenqing Yin, Ryuji Morizane

“…While the worldwide prevalence of kidney disease is increasing rapidly, the current therapeutic repertoire for these patients is often limited to dialysis and…”
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Efficient generation of ETX embryoids that recapitulate the entire window of murine egg cylinder development by Dupont, Cathérine, Schäffers, Olivier J M, Tan, Beatrice F, Merzouk, Sarra, Bindels, Eric M, Zwijsen, An, Huylebroeck, Danny, Gribnau, Joost

“…The murine embryonic-trophoblast-extra-embryonic endoderm (ETX) model is an integrated stem cell-based model to study early postimplantation development. It is…”
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Standardization of a method to assess mushroom blotch resistance in cultivated and wild Agaricus bisporus strains by Olivier, J.M, Mamoun, M, Munsch, P

“…Brown blotch disease of Agaricus bisporus is caused by Pseudomonas tolaasii and is responsible for losses of 8-10% worldwide during commercial production…”
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Hypoxia Triggers TAZ Phosphorylation in Basal A Triple Negative Breast Cancer Cells by Liu, Qiuyu, Stel, Wanda van der, Noord, Vera E. van der, Leegwater, Hanneke, Coban, Bircan, Elbertse, Kim, Pruijs, Joannes T. M., Béquignon, Olivier J. M., Westen, Gerard van, Dévédec, Sylvia E. Le, Danen, Erik H. J.

“…Hypoxia and HIF signaling drive cancer progression and therapy resistance and have been demonstrated in breast cancer. To what extent breast cancer subtypes…”
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Pseudomonas tolaasii: extra-genomic factor mediates toxin production and efficiency by Mamoun, M, Moquet, F, Laffitte, J, Olivier, J.M

“…Pseudomonas tolaasii responsible for brown blotch symptoms on Agaricus bisporus. Investigations among 15 P. tolaasii wild-type strains revealed the existence…”
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