Search Results - "Olivier, Humbert"

Dissociated Response in Metastatic Cancer: An Atypical Pattern Brought Into the Spotlight With Immunotherapy by Humbert, Olivier, Chardin, David

“…When evaluating metastatic tumor response to systemic therapies, dissociated response is defined as the coexistence of responding and non-responding lesions…”
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Learning a confidence score and the latent space of a new supervised autoencoder for diagnosis and prognosis in clinical metabolomic studies by Chardin, David, Gille, Cyprien, Pourcher, Thierry, Humbert, Olivier, Barlaud, Michel

“…Presently, there is a wide variety of classification methods and deep neural network approaches in bioinformatics. Deep neural networks have proven their…”
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Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism by Adams, Kristin N., Takaki, Kevin, Connolly, Lynn E., Wiedenhoft, Heather, Winglee, Kathryn, Humbert, Olivier, Edelstein, Paul H., Cosma, Christine L., Ramakrishnan, Lalita

“…Treatment of tuberculosis, a complex granulomatous disease, requires long-term multidrug therapy to overcome tolerance, an epigenetic drug resistance that is…”
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Influence of Software Tool and Methodological Aspects of Total Metabolic Tumor Volume Calculation on Baseline [18F]FDG PET to Predict Survival in Hodgkin Lymphoma by Kanoun, Salim, Tal, Ilan, Berriolo-Riedinger, Alina, Rossi, Cédric, Riedinger, Jean-Marc, Vrigneaud, Jean-Marc, Legrand, Louis, Humbert, Olivier, Casasnovas, Olivier, Brunotte, François, Cochet, Alexandre

“…To investigate the respective influence of software tool and total metabolic tumor volume (TMTV0) calculation method on prognostic stratification of baseline…”
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Primal-dual for classification with rejection (PD-CR): a novel method for classification and feature selection-an application in metabolomics studies by Chardin, David, Humbert, Olivier, Bailleux, Caroline, Burel-Vandenbos, Fanny, Rigau, Valerie, Pourcher, Thierry, Barlaud, Michel

“…Supervised classification methods have been used for many years for feature selection in metabolomics and other omics studies. We developed a novel primal-dual…”
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Baseline metabolic tumor volume as a strong predictive and prognostic biomarker in patients with non-small cell lung cancer treated with PD1 inhibitors: a prospective study by Chardin, David, Paquet, Marie, Schiappa, Renaud, Darcourt, Jacques, Bailleux, Caroline, Poudenx, Michel, Sciazza, Aurélie, Ilie, Marius, Benzaquen, Jonathan, Martin, Nicolas, Otto, Josiane, Humbert, Olivier

“…Reliable predictive and prognostic markers are still lacking for patients treated with programmed death receptor 1 (PD1) inhibitors for non-small cell lung…”
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Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates by Peterson, Christopher W., Wang, Jianbin, Norman, Krystin K., Norgaard, Zachary K., Humbert, Olivier, Tse, Collette K., Yan, Jenny J., Trimble, Richard G., Shivak, David A., Rebar, Edward J., Gregory, Philip D., Holmes, Michael C., Kiem, Hans-Peter

“…Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a promising novel technology for the treatment of many human diseases. Here, we evaluated…”
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Total metabolic tumor volume on 18F-FDG PET/CT is a game-changer for patients with metastatic lung cancer treated with immunotherapy by Tricarico, Pierre, Chardin, David, Martin, Nicolas, Contu, Sara, Hugonnet, Florent, Otto, Josiane, Humbert, Olivier

“…PurposeBecause of atypical response imaging patterns in patients with metastatic non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors…”
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Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity by Swaim, Laura E, Connolly, Lynn E, Volkman, Hannah E, Humbert, Olivier, Born, Donald E, Ramakrishnan, Lalita

“…The zebrafish, a genetically tractable model vertebrate, is naturally susceptible to tuberculosis caused by Mycobacterium marinum, a close genetic relative of…”
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[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression by Dadone-Montaudié, Bérengère, Ambrosetti, Damien, Dufour, Maxime, Darcourt, Jacques, Almairac, Fabien, Coyne, John, Virolle, Thierry, Humbert, Olivier, Burel-Vandenbos, Fanny

“…[18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain…”
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FDG PET/CT for prognostic stratification of patients with metastatic breast cancer treated with first line systemic therapy: Comparison of EORTC criteria and PERCIST by Depardon, Edouard, Kanoun, Salim, Humbert, Olivier, Bertaut, Aurélie, Riedinger, Jean-Marc, Tal, Ilan, Vrigneaud, Jean-Marc, Lasserre, Maud, Toubeau, Michel, Berriolo-Riedinger, Alina, Dygai-Cochet, Inna, Fumoleau, Pierre, Brunotte, François, Cochet, Alexandre

“…Evaluate response and predict prognosis of patients with newly diagnosed metastatic breast cancer treated with first line systemic therapy using European…”
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Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components by Humbert, Olivier, Salama, Nina R

“…The naturally competent organism Helicobacter pylori encodes a large number of restriction-modification (R-M) systems that consist of a restriction…”
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Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations by Samuelson, Clare, Radtke, Stefan, Zhu, Haiying, Llewellyn, Mallory, Fields, Emily, Cook, Savannah, Huang, Meei-Li W., Jerome, Keith R., Kiem, Hans-Peter, Humbert, Olivier

“…Sickle cell disease and β-thalassemia are common monogenic disorders that cause significant morbidity and mortality globally. The only curative treatment…”
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TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction by Lux, Christopher T, Pattabhi, Sowmya, Berger, Mason, Nourigat, Cynthia, Flowers, David A, Negre, Olivier, Humbert, Olivier, Yang, Julia G, Lee, Calvin, Jacoby, Kyle, Bernstein, Irwin, Kiem, Hans-Peter, Scharenberg, Andrew, Rawlings, David J

“…Elements within the γ-hemoglobin promoters ( and ) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell…”
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A Nonhuman Primate Transplantation Model to Evaluate Hematopoietic Stem Cell Gene Editing Strategies for β-Hemoglobinopathies by Humbert, Olivier, Peterson, Christopher W, Norgaard, Zachary K, Radtke, Stefan, Kiem, Hans-Peter

“…Reactivation of fetal hemoglobin (HbF) is a promising approach for the treatment of β-hemoglobinopathies and the targeting of genes involved in HbF regulation…”
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In-house Implementation of Tumor Mutational Burden Testing to Predict Durable Clinical Benefit in Non-small Cell Lung Cancer and Melanoma Patients by Heeke, Simon, Benzaquen, Jonathan, Long-Mira, Elodie, Audelan, Benoit, Lespinet, Virginie, Bordone, Olivier, Lalvée, Salomé, Zahaf, Katia, Poudenx, Michel, Humbert, Olivier, Montaudié, Henri, Dugourd, Pierre-Michel, Chassang, Madleen, Passeron, Thierry, Delingette, Hervé, Marquette, Charles-Hugo, Hofman, Véronique, Stenzinger, Albrecht, Ilié, Marius, Hofman, Paul

“…Tumor mutational burden (TMB) has emerged as an important potential biomarker for prediction of response to immune-checkpoint inhibitors (ICIs), notably in…”
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Comparison of unsupervised machine-learning methods to identify metabolomic signatures in patients with localized breast cancer by Gal, Jocelyn, Bailleux, Caroline, Chardin, David, Pourcher, Thierry, Gilhodes, Julia, Jing, Lun, Guigonis, Jean-Marie, Ferrero, Jean-Marc, Milano, Gerard, Mograbi, Baharia, Brest, Patrick, Chateau, Yann, Humbert, Olivier, Chamorey, Emmanuel

“…[Display omitted] Genomics and transcriptomics have led to the widely-used molecular classification of breast cancer (BC). However, heterogeneous biological…”
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Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates by Petty, Nicholas E., Radtke, Stefan, Fields, Emily, Humbert, Olivier, Llewellyn, Mallory J., Laszlo, George S., Zhu, Haiying, Jerome, Keith R., Walter, Roland B., Kiem, Hans-Peter

“…Current immunotherapeutic targets are often shared between neoplastic and normal hematopoietic stem and progenitor cells (HSPCs), leading to unwanted…”
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Survival analysis of patient groups defined by unsupervised machine learning clustering methods based on patient metabolomic data by Bailleux, Caroline, Chardin, David, Guigonis, Jean-Marie, Ferrero, Jean-Marc, Chateau, Yann, Humbert, Olivier, Pourcher, Thierry, Gal, Jocelyn

“…Meta-analyses failed to accurately identify patients with non-metastatic breast cancer who are likely to benefit from chemotherapy, and metabolomics could…”
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Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells by Peterson, Christopher W., Venkataraman, Rasika, Reddy, Sowmya S., Pande, Dnyanada, Enstrom, Mark R., Radtke, Stefan, Humbert, Olivier, Kiem, Hans-Peter

“…Over the past decade, numerous gene-editing platforms which alter host DNA in a highly specific and targeted fashion have been described. Two notable examples…”
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